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Found 113 clinical trials
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD) (PROTECT-ICD)

secondary aim is to assess the utility of cardiac MRI (CMR) in analysing cardiac function and viability as well as predicting inducible and spontaneous ventricular tachyarrhythmia when performed early post

  • 15 May, 2022
  • 26 locations
Study of Cardiac MRI in the Follow up Assessment of Patients With PAH (EVITA)

Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance leading to right ventricular failure and eventually to death. The therapeutic strategy has become complex and needs to perform recurring follow up evaluations including right heart catheterizations (RHC). Cardiac magnetic resonance imaging (cMRI) has the advantage …

  • 10 May, 2021
  • 1 location
Allograft Dysfunction in Heart Transplant

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

  • 03 Feb, 2022
  • 1 location
Dual MRI for Cardiopulmonary COVID-19 Long Haulers

6-9 months later. Cardiac MRI will assess the myocardial status and right ventricular function, while hyperpolarized 129Xe MRI will provide a 3D assessment of pulmonary ventilation, interstitial

  • 26 Sep, 2021
  • 1 location
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During Interleukin-6 vs. Tumor Necrosis Factor Antibody Therapy (RABEX)

The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with rheumatoid arthritis. The investigators hypothesize that blockage of IL-6 receptors will decrease the cardiac and metabolic adaptations to exercise training compared to the …

tumour necrosis
tumor necrosis factor
Accepts healthy volunteers
  • 10 Mar, 2022
  • 1 location
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS

having scarring is higher they will undergo a cardiac MRI scan. If scarring is present participants will be randomised to routine clinical care, or referral for valve replacement surgery. Participants

cardiac mri
transcatheter aortic valve implantation
  • 06 May, 2021
  • 1 location
A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients. (RESTORE-MI)

Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving can cause this clot to break up and get washed downstream, …

  • 22 Mar, 2022
  • 3 locations
Routine Cardiac Screening in Sarcoidosis Patients (PAPLAND)

This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient's history of symptoms and under go an ECG. If a patient has an abnormal …

cardiac sarcoidosis
  • 15 Feb, 2022
  • 5 locations
Heart Disease of the Small Arteries in Women and Men

Women suffer disproportionately than men from Cardiac Syndrome X ( chest pain in the absence of flow limiting coronary artery stenosis). Coronary microvascular disease is hypothesized to mediate chest pain in this syndrome. This disorder of the small heart vessels (arterioles) compared to the large vessels (arteries) is not diagnosed …

angina pectoris
ace inhibitor
heart disease
  • 23 Jan, 2022
  • 1 location
Arrhythmic Risk Stratification in Nonischemic Dilated Cardiomyopathy

Nonischemic dilated cardiomyopathy is a heterogeneous disease often associated with increased rates of sudden cardiac death. Although many algorithms have been proposed, risk stratification remains suboptimal, and implantable cardioverter-defibrillators are currently recommended only in patients with poor left ventricular function. However, most cases of sudden cardiac death occur at earlier …

  • 09 May, 2021
  • 1 location