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Found 101 clinical trials
Programmed Ventricular Stimulation to Risk Stratify for Early Cardioverter-Defibrillator (ICD) Implantation to Prevent Tachyarrhythmias Following Acute Myocardial Infarction (PROTECT-ICD) (PROTECT-ICD)

secondary aim is to assess the utility of cardiac MRI (CMR) in analysing cardiac function and viability as well as predicting inducible and spontaneous ventricular tachyarrhythmia when performed early post

  • 15 May, 2022
  • 26 locations
Allograft Dysfunction in Heart Transplant

The investigators will evaluate for early evidence of cardiac allograft dysfunction by cardiac MRI and single cell sequencing to determine underlying molecular and macroscopic causes.

  • 03 Feb, 2022
  • 1 location
Evaluation of Spectral Cardiac CT for the Diagnosis of Acute Myocarditis (MYOCARDITESCAN)

Spectral cardiac CT scan performed in an emergency setting in patients with suspected acute myocarditis and presenting one selves with an acute chest pain, allows the non-invasive assessment of both the coronary arteries and the myocardium. Delayed iodine contrast-enhanced CT imaging should show the inflamed area with an increased uptake …

  • 04 Oct, 2022
  • 1 location
Exercise-induced Cardiac Adaptions in Rheumatoid Arthritis Patients During Interleukin-6 vs. Tumor Necrosis Factor Antibody Therapy (RABEX)

The present study will investigative the physiological effects of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) on the adaptive changes to exercise in patients with rheumatoid arthritis. The investigators hypothesize that blockage of IL-6 receptors will decrease the cardiac and metabolic adaptations to exercise training compared to the …

tumour necrosis
tumor necrosis factor
Accepts healthy volunteers
  • 10 Mar, 2022
  • 1 location
Caloric Restriction and Exercise for Protection From Anthracycline Toxic Effects (CREATE)

Doxorubicin and epirubicin are part of the class of chemotherapy agents called anthracyclines that are commonly used to treat breast cancer. Although these treatments work well against the tumor, they are known to cause damage to the heart muscle, resulting in diminished heart function that can be permanent, and may …

breast cancer
breast cancer staging
  • 04 Oct, 2022
  • 1 location
Early Valve Replacement Guided by Biomarkers of LV Decompensation in Asymptomatic Patients With Severe AS (EVoLVeD)

having scarring is higher they will undergo a cardiac MRI scan. If scarring is present participants will be randomised to routine clinical care, or referral for valve replacement surgery. Participants

valvular disease
transcatheter aortic valve implantation
aortic valve stenosis
  • 02 Jun, 2022
  • 1 location
A Study of Low-dose Intracoronary Thrombolytic Therapy in STEMI (Heart Attack) Patients. (RESTORE-MI)

Heart attacks are caused by a blood clot blocking the blood vessels of the heart, preventing blood getting to the heart muscle. Opening up the artery with a balloon (angioplasty) and a small mesh tube (stent) although life saving can cause this clot to break up and get washed downstream, …

  • 22 Mar, 2022
  • 3 locations
Routine Cardiac Screening in Sarcoidosis Patients (PAPLAND)

This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient's history of symptoms and under go an ECG. If a patient has an abnormal …

cardiac sarcoidosis
  • 15 Feb, 2022
  • 5 locations
Heart Disease of the Small Arteries in Women and Men

Women suffer disproportionately than men from Cardiac Syndrome X ( chest pain in the absence of flow limiting coronary artery stenosis). Coronary microvascular disease is hypothesized to mediate chest pain in this syndrome. This disorder of the small heart vessels (arterioles) compared to the large vessels (arteries) is not diagnosed …

ace inhibitor
heart disease
hmg-coa reductase inhibitors
hmg-coa reductase inhibitor
  • 23 Jan, 2022
  • 1 location
4D-flow Cardiac MRI to Assess Pulmonary Arterial Pressure in Pulmonary Hypertension

cardiac MRI exam with the addition of a 4D Flow sequence (does not require supplementary injection of a contrast agent and does not extend the duration of the examination) followed promptly (within the

right heart catheterization
pulmonary arterial pressure
  • 19 Nov, 2021
  • 1 location