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Found 37 clinical trials
Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy With or Without the Use of Coronary Calcium Screening in Preventing Future Major Adverse Cardiac Events

The primary objective of this study is to test the effectiveness of a proactive cardiovascular primary prevention strategy, with or without the use of coronary calcium screening, compared to current standard care, in preventing future major adverse cardiac events (MACE), including all-cause death, non-fatal myocardial infarction (MI), stroke, or any …

  • 14 Apr, 2021
  • 1 location
Limitations of Aerobic Capacity in Chronic Heart Failure

This study will use a novel CPX test that incorporates instantaneous assessment of maximal isokinetic cycling power at VO2peak to elucidate the mechanisms that limit VO2peak in CHF, and compare these responses with age-matched controls.

  • 08 May, 2021
  • 1 location
Drug-coating Balloon Angioplasties for True Coronary Bifurcation Lesions

composite endpoint of major adverse cardiac event (MACE) at 12 months. The individual components of MACE include cardiac death, myocardial infarction (MI), or target lesion revascularization (TLR). True

myocardial infarction
percutaneous coronary intervention
cardiac event
  • 26 Jan, 2021
  • 1 location
Treatment of Cardiovascular Disease With Low Dose Rivaroxaban in Advanced Chronic Kidney Disease

cardiac event (MACE) in people with Chronic Kidney Disease (CKD) stages 4 or 5 or dialysis-dependent End Stage Kidney Disease (ESKD), and elevated cardiovascular (CV) risk, whilst maintaining an

  • 19 Jul, 2021
  • 44 locations
Safety and Efficacy of AT-001 in Patients With Diabetic Cardiomyopathy

This is a multicenter, randomized, placebo-controlled, 2-part study to evaluate the safety and efficacy of AT-001 in adult patients (N=675) with Diabetic Cardiomyopathy at high risk of progression to overt heart failure.

heart failure
  • 21 Jun, 2021
  • 80 locations
Remote Exercise SWEDEHEART Study

The overall aim of the study is to evaluate if remote video exercise-based cardiac rehabilitation (exCR), offered as an alternative to centre-based exCR, can increase the proportion of patients post myocardial infarction (MI) successfully completing an exCR-program.

acute myocardial infarction
myocardial infarction
cardiac rehabilitation
  • 28 Jan, 2021
  • 30 locations
Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT

Myocardial infarction with non-obstructive coronary arteries" (MINOCA) occurs in 5-10% of all patients with AMI. There are neither any randomized clinical trials in MINOCA patients evaluating effects of secondary preventive treatments proven beneficial in patients with classic AMI, nor any treatment guidelines. The primary objective of this multi-national, multi-center pragmatic …

  • 16 Sep, 2021
  • 19 locations
Tranexamic Acid for Acute Upper Gastrointestinal Bleed in Cirrhosis

The management of acute upper gastrointestinal bleeding (UGIB) is challenging in patients with cirrhosis, as it is responsible for severe complications and high mortality rates. Fibrinolytic activity of the epithelial surfaces and of the submucosal blood vessels may interfere with hematemesis and even delay healing of ulcers. Tranexamic acid (TXA) …

  • 26 Jan, 2021
  • 1 location
Preventing Adverse Cardiac Events in COPD

A double-blind, randomised controlled trial in participants with COPD to assess the efficacy of proactive treatment of cardiac risk in people with COPD. We hypothesise that treating known and undiagnosed CVD in COPD participants will improve both cardiac and respiratory outcomes.

coronary disease
copd exacerbation
  • 25 Jan, 2021
  • 17 locations
Post Acute Cardiac Event Smoking (PACES) Study

Summary of the Project : Quitting smoking following acute coronary syndrome (ACS) can reduce mortality up to 50%. However, depression and smoking are highly co-morbid and depressed mood may interfere with cessation and independently predicts mortality. Thus, a single, integrated treatment for both smoking and depression could be highly effective …

smoking cessation therapy
nicotine product
acute coronary syndrome
smoking cessation
nicotine patch
  • 23 May, 2021
  • 1 location