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Found 28 clinical trials
Pazopanib vs. Pazopanib Plus Gemcitabine

This study is a prospective, randomized, open-label, multicenter phase II trial in order to determine progression-free survival of patients with refractory or relapsed metastatic uterine leiomyosarcomas or other metastatic uterine tumours.

  • 2 views
  • 28 Jan, 2021
  • 16 locations
ATr Inhibitor in Combination With Olaparib in Gynaecological Cancers With ARId1A Loss or no Loss

ATARI trial tests the ATR inhibitor drug AZD6738 and a PARP inhibitor drug olaparib in patients with relapsed gynecological cancers to assess the response in groups of patients selected based on their cancer cell subtype and the presence of an abnormality in ARID1A gene.

  • 4 views
  • 25 Jan, 2021
  • 1 location
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

carcinoma (temporarily closed to accrual 04/29/2020) Clear cell cervical cancer Esthenioneuroblastoma (closed to accrual) Endometrial carcinosarcoma (malignant mixed Mullerian

tubal ligation
vasectomy
bilateral oophorectomy
hydrocortisone
seminoma
  • 6048 views
  • 24 Sep, 2021
  • 818 locations
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus

Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.

  • 0 views
  • 01 Sep, 2021
  • 1 location
ZW25 in Women With Endometrial Cancers

This study is being done to test the drug ZW25 and look at whether this drug is effective in women with HER2-overexpressed endometrial cancer or carcinosarcoma that has been treated in the past

x-rays
measurable disease
neutrophil count
endocrine therapy
hormone therapy
  • 0 views
  • 10 Jul, 2021
  • 8 locations
Does Cediranib With Paclitaxel or Cediranib and Olaparib Treat Advanced Endometrial Cancer Better Than Paclitaxel?

The COPELIA trial is evaluating two new tablet medications in endometrial cancer for the first time. It will include 129 women aged 16 years or older with advanced endometrial cancer whose cancer has worsened after their initial chemotherapy treatment. Participants will be allocated at random to one of three groups: …

ovarian cancer
measurable disease
neutrophil count
olaparib
recurrent endometrial cancer
  • 30 views
  • 23 Jan, 2021
  • 11 locations
A Study of Nivolumab in Selected Uterine Cancer Patients

The purpose of this study is to test the safety of nivolumab and find out what affects, if any, nivolumab has on people and their risk of gynecologic cancer. The investigators also want to find out what effects, good or bad, nivolumab has on the patient and their cancer.

measurable disease
fallopian tube
gynecologic cancer
sarcoma
gilbert's syndrome
  • 100 views
  • 22 Sep, 2021
  • 11 locations
Stereotactic Pelvic Adjuvant Radiation Therapy in Cancers of the Uterus.

Advanced technology has enabled radiation oncologists to more accurately and precisely target radiation to areas at risk while maximally sparing healthy tissue. Furthermore, there is growing evidence demonstrating both safety and efficacy for SBRT. We propose that these advantages are translatable to the adjuvant treatment of endometrial cancer. We submit …

uterine disease
adenocarcinoma
carcinoma
immunomodulators
carcinosarcoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Recurrent Ovarian CarcinoSarcoma Anti-pd-1 Niraparib

Carcinosarcomas (CS) (malignant mixed Mllerian tumors) are highly aggressive and rare tumors with a worldwide annual incidence between 0.5-3.3 cases/100.000 women. Gynecological CS, i.e. ovarian CS (OCS) and uterine CS (UCS), have a 5-year overall survival (OS) < 10% and a poor prognosis. After initial treatment (surgery +/- adjuvant radiotherapies …

  • 0 views
  • 16 Aug, 2021
  • 21 locations
AZD1775 in Women With Recurrent or Persistent Uterine Serous Carcinoma or Uterine Carcinosarcoma

This research study is studying an investigational drug as a possible treatment for uterine cancer. The drug involved in this study is: -AZD1775

carcinosarcoma
measurable disease
carcinoma
neutrophil count
metastasis
  • 20 views
  • 17 Jul, 2021
  • 1 location