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Found 99 clinical trials
Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) Versus Intensity-Modulated Photon Therapy (IMRT) for the Treatment of Oropharyngeal Cancer of the Head and Neck

The goal of this clinical research study is to compare the side effects of 2 radiation treatments for head and neck cancer. The 2 treatments are intensity modulated photon therapy (IMRT) and intensity modulated proton therapy (IMPT). Participants will also receive chemotherapy along with radiation therapy. IMPT is designed to …

carcinoma
squamous cell carcinoma
x-rays
oropharyngeal
concurrent chemotherapy
  • 41 views
  • 13 Apr, 2021
  • 11 locations
Stereotactic Body Radiation Therapy and Durvalumab With or Without Tremelimumab Before Surgery in Treating Participants With Human Papillomavirus Positive Oropharyngeal Squamous Cell Caner

This phase Ib/II trial studies the side effects and how well stereotactic body radiation therapy and durvalumab with or without tremelimumab before surgery work in treating participants with human papillomavirus positive oropharyngeal squamous cell cancer. Stereotactic body radiation therapy is a specialized radiation therapy that sends x-rays directly to the …

carcinoma
x-rays
platelet count
robotic surgery
neck dissection
  • 2 views
  • 27 Jan, 2021
  • 1 location
Study of Hypoxia Measured in F-Miso PET/Scan and MRI in Patients With Squamous Cells Carcinoma

Hypoxia imaging has not been studied extensively by combining PET and MRI data. Few studies performed the double imaging and none associated anatomopathology with it . This study will use a rigorous methodology through the production of PET/MRI images at the same time by transferring the patient directly from PET …

carcinoma
pet/mri
oropharyngeal carcinoma
  • 0 views
  • 25 Jan, 2021
  • 1 location
  • 0 views
  • 24 May, 2021
  • 1 location
Radiotherapy vs. Trans-Oral Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma

The goal of this randomized phase II study is a formal comparison of radiotherapy versus trans-oral surgery as the primary treatment of HPV-negative patients with early-stage oropharyngeal

primary tumor
oropharyngeal carcinoma
squamous cell carcinoma
carcinoma
anesthesia
  • 0 views
  • 25 Jan, 2021
  • 1 location
Carboplatin Nab-Paclitaxel Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

Participants in this study have a type of cancer called squamous cell carcinoma of the head and neck (SCCHN). Their SCCHN has spread around the area where the cancer first started. This is called locally-advanced SCCHN. These participants are eligible for surgery. Previous research with a similar therapy regimen resulted …

chemotherapy regimen
platelet count
renal function test
skin cancer
caries
  • 101 views
  • 24 Jan, 2021
  • 2 locations
Radiation Therapy and Cisplatin With or Without Cetuximab in Treating Patients With HPV Positive KRAS-Variant Stage III-IV Oropharyngeal Squamous Cell Carcinoma

This phase II trial studies how well radiation therapy and cisplatin with or without cetuximab works in treating patients with human papillomavirus (HPV) positive, KRAS-variant stage III-IV oropharyngeal squamous cell carcinoma. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Drugs used in chemotherapy, such as …

  • 0 views
  • 02 Apr, 2021
  • 1 location
Combination Immunotherapy in Subjects With Advanced HPV Associated Malignancies

cervical cancers; P16+ oropharyngeal cancers; anal cancers; vulvar, vaginal, penile, and squamous cell rectal cancers; or other locally advanced or metastatic solid tumors (e.g., lung, esophagus) that are

oropharyngeal carcinoma
hepatitis b
solid tumors
liver metastases
pelvic radiation
  • 15 views
  • 04 Jun, 2021
  • 1 location
HPV Vaccine PRGN-2009 Alone or in Combination With Anti-PDL1/TGF-Beta Trap (M7824) in Subjects With HPV Associated Cancers

metastatic HPV associated cancer (Phase I) or stage II or III p16-positive oropharyngeal cancer (Phase II) Design Participants will be screened with: Medical

oropharyngeal carcinoma
atezolizumab
hepatitis b
solid tumors
oropharyngeal squamous cell carcinoma
  • 0 views
  • 14 Jun, 2021
  • 1 location
Postoperative Pain Why Still in Hospital and DAOH Following TORS for SCCUP

This protocol investigates the effect of a high dose dexamethasone regimen in the treatment of postoperative pain following Transoral Robotic Surgery (TORS). The protocol consists of three substudies. Randomized double-blinded clinical trial assigning half of the participants to a high-dose dexamethasone regimen while the other half will receive a low-dose …

carcinoma
squamous cell carcinoma
postoperative pain
dexamethasone
robotic surgery
  • 0 views
  • 24 Jan, 2021
  • 1 location