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Found 99 clinical trials
Feasibility and Tolerance of Nivolumab Neoadjuvant Immunotherapy in High Risk HPV Driven Oropharynx Cancer

The aim of this research is to study the feasibility of neoadjuvant treatment before chemoradiation in "high risk" HPV-driven Oropharynx cancer

immunohistochemistry
squamous cell carcinoma
hpv dna
carcinoma
oropharyngeal cancer
  • 1 views
  • 24 May, 2021
  • 12 locations
Adaptive Treatment De-escalation in Favorable Risk HPV-Positive Oropharyngeal Carcinoma

This will be a phase II single-arm clinical trial. The purpose of this study is to determine the feasibility of deescalating chemoradiation treatment based onmid-treatment tumor response. The primary objective of this study is to evaluate progression-free survival at 2 years.

hpv infection
papillary squamous cell carcinoma
ct scan
immunohistochemistry
squamous cell carcinoma
  • 7 views
  • 25 Jan, 2021
  • 1 location
HYHOPE: De-intensified Hypofractionated Radiation Therapy for HPV-associated Oropharynx Cancer

This is a single arm Phase I study of de-intensified hypofractionated radiation therapy for favorable human papilloma virus-associated oropharynx cancer. It will evaluate the tolerability of a

  • 0 views
  • 04 Jun, 2021
  • 1 location
Toripalimab Based Induction Chemotherapy Followed by De-escalation Protocols in HPV-related OPSCC

Human papillomavirus (HPV)-related oropharyngeal carcinoma are exquisitely radiosensitive. Several studies attempted to reduce the toxicities of treatments through reduced-dose radiation and

  • 0 views
  • 11 May, 2021
  • 1 location
PROGRESS Trial - Prophylactic Gabapentin for Relief of Symptoms and Improved Swallowing

supportive care for locoregionally-advanced, HPV-related oropharyngeal cancer. Secondary purposes include comparison of total equivalent opioid dosage above baseline opioid use at end of treatment, quality

gabapentin
cancer
mucositis
oropharyngeal cancer
opioid
  • 11 views
  • 25 Jan, 2021
  • 1 location
Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma

The purpose of this study is to demonstrate that participants with HPV positive and hypoxia negative T1-2, N1-2c (AJCC, 7th ed.) oropharyngeal squamous cell carcinoma receiving a major de-escalated radiation therapy with 2 cycles of standard chemotherapy is not inferior to comparable subjects treated with the current standard chemoradiation. Accrual …

  • 22 views
  • 16 Mar, 2021
  • 9 locations
Transdisciplinary Oral/Oropharyngeal Cancer Research & Care in Head and Neck Cancer (TORCH)

The purpose of this research study is to see if it is possible to collect tissue, saliva and blood samples from patients who are having surgery and send those samples to different labs across MUSC. The researchers in these labs will collect tissue, blood and saliva samples before surgery and …

oropharyngeal
carcinoma of oropharynx
squamous cell carcinoma
squamous cell carcinoma of the oral cavity
carcinoma
  • 0 views
  • 26 Jan, 2021
  • 1 location
Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

This trial will explore giving standard dose chemotherapy and radiation therapy to sites of disease including all lymph nodes involved with HPV-positive oropharyngeal cancer, but administer

  • 0 views
  • 26 Jan, 2021
  • 1 location
Digital PET Scan for the Prediction of Outcomes in Patients With Locally Advanced Oropharyngeal Cancer

This trial studies how well digital PET scan works in predicting outcomes in patients with oropharyngeal cancer that has spread from where it started to nearby tissue or lymph nodes (locally

  • 0 views
  • 18 Mar, 2021
  • 1 location
Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer

low risk human papilloma virus positive oropharyngeal cancer. This is an investigational study. MRI simulations and radiation therapy are delivered using FDA-approved and commercially available

immunohistochemistry
squamous cell carcinoma
primary tumor
carcinoma
oropharyngeal cancer
  • 9 views
  • 23 Jan, 2021
  • 1 location