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Found 99 clinical trials
Concomitant Immune Check Point Inhibitor With Radiochemotherapy in Head And Neck Cancer

Background: Locally advanced head and neck cancer (HNC) is a challenge as, in spite of initial good control with chemoradiation, the majority of patients fails systemically. In the last 2 years, immune check points inhibitors (mainly Programmed Death (PD)-1 inhibitors) were approved for metastatic/recurrent HNC. The favorable toxicity profile and …

  • 26 Apr, 2021
  • 1 location
CompARE: Escalating Treatment of Intermediate and High-risk Oropharyngeal Cancer (OPC)

CompARE is a multicentre, phase III open-label randomised controlled trial using an adaptive, Multi-Arm, Multi-Stage (MAMS) design.

squamous cell carcinoma
serum pregnancy test
oropharyngeal squamous cell carcinoma
renal function test
  • 24 Jan, 2021
  • 33 locations
Study Assessing The "Best of" Radiotherapy vs the "Best of" Surgery in Patients With Oropharyngeal Carcinoma

Oropharyngeal Squamous Cell Carcinoma (OPSCC) arises in the soft palate, tonsils, base of tongue, pharyngeal wall, and the vallecula. Most of the patients with early stage OPSCC are usually cured. Treatment of early stage OPSCC can be successfully achieved with primary surgery including neck dissection, as indicated, or with definitive …

squamous cell carcinoma
oropharyngeal squamous cell carcinoma
platelet count
intensity-modulated radiation therapy
extracapsular extension
  • 14 May, 2021
  • 32 locations
Enhancing Self Care Among Oral Cancer Survivors: The Empowered Survival Trial

Project's goal is evaluate an online tool the research team created called Empowered Survivor (ES) against a free online self-management intervention developed for cancer survivors by the National Cancer Institute and the American Cancer Society called Springboard Beyond Cancer.

  • 15 Apr, 2021
  • 1 location
Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.

Radiotherapy with or without adjuvant chemotherapy represents an important column of modern therapy in advanced squamous cell originated tumours of the head and neck. However to date no studies are available which study the effectiveness of radiotherapy in patients with resected small tumours (T1, T2) and concomitant ipsilateral metastasis of …

histological diagnosis
squamous cell carcinoma
squamous cell carcinoma of the oral cavity
  • 08 Nov, 2020
Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)

The main objectives of the PATHOS study are: To assess whether swallowing function can be improved following transoral resection of HPV-positive OPSCC, by reducing the intensity of adjuvant treatment protocols. The aim is to personalise treatment, based on disease biology (HPV status and pathology findings), to optimise patient outcomes. To …

  • 25 Jan, 2021
  • 45 locations
De-intensified Radiation Therapy With Chemotherapy (Cisplatin) or Immunotherapy (Nivolumab) in Treating Patients With Early-Stage HPV-Positive Non-Smoking Associated Oropharyngeal Cancer

oropharyngeal cancer that is early in its growth and may not have spread to other parts of the body (early-stage), and is not associated with smoking. Radiation therapy uses high-energy x-rays to kill tumor

primary tumor
  • 20 Jun, 2021
  • 225 locations
Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

overall survival (time being alive) and progression-free survival (time being alive without cancer) for patients with intermediate risk human papillomavirus (HPV) positive oropharynx cancer (throat cancer

  • 20 Jun, 2021
  • 539 locations
A Randomized Phase 2 Study of Cemiplimab ISA101b in HPV16-Positive OPC

This will be a blinded, placebo-controlled, randomized, phase 2 study in which subjects will be randomly assigned 1:1 to cemiplimab plus placebo or cemiplimab plus ISA101b.

treatment schedule
ct scan
measurable disease
  • 27 Apr, 2021
  • 57 locations
NBTXR3 and Radiation Therapy in Treating Patients With Locally Advanced SCC of the Oral Cavity or Oropharynx

oropharyngeal cancers can obstruct the air flow or infiltrate muscles or nerves, which significantly disturb local functions. The incidence of Head and Neck Squamous Cell Cancer in patients older 65 years is

carcinoma of oropharynx
ct scan
squamous cell carcinoma of the oral cavity
primary tumor
locally advanced squamous cell carcinoma
  • 16 May, 2021
  • 20 locations