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Found 40 clinical trials
Randomized, Double-Blinded Phase III Study of Cabozantinib Versus Placebo in Patients With Advanced Neuroendocrine Tumors After Progression on Prior Therapy (CABINET)

This phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that have spread to other places in the body

somatostatin
sunitinib
hepatic artery embolization
radionuclide therapy
platelet count
  • 191 views
  • 27 Oct, 2022
  • 216 locations
Molecular-Guided Surgery for Pancreatic and GI Neuroendocrine Cancers

The purpose of this study is to see if the use of 68Gallium- positron emission tomography and computer tomography (PET/CT) scans along with NETSPOT (Advanced Accelerator Applications USA, Inc.) can better define the localization of Neuroendocrine tumors enhancing the surgical removal of Neuroendocrine tumors (NETs).

neuroendocrine tumor
positron emission tomography
cancer
dotatate
pet/ct scan
  • 0 views
  • 04 Oct, 2022
  • 1 location
A Phase II Study of Lenvatinib in Combination With Everolimus in Patients With Advanced Carcinoid Tumors

This phase II trial studies how well lenvatinib and everolimus work in treating patients with carcinoid tumors that have spread to other places in the body (advanced) and cannot be removed by

somatostatin
men1
measurable disease
multiple endocrine neoplasia type 1
everolimus
  • 2 views
  • 13 Oct, 2022
  • 1 location
Phase 1b/3 Global, Randomized, Controlled, Open-label Trial Comparing Treatment With RYZ101 to Standard of Care Therapy in Subjects With Inoperable, Advanced, SSTR+, Well-differentiated GEP-NETs That Have Progressed Following Prior 177Lu-SSA Therapy (ACTION-1)

This study aims to determine the safety, pharmacokinetics (PK) and recommended Phase 3 dose (RP3D) of RYZ101 in Part 1, and the safety, efficacy, and PK of RYZ101 compared with investigator-selected standard of care (SoC) therapy in Part 2 in subjects with inoperable, advanced, well-differentiated, somatostatin receptor expressing (SSTR+) gastroenteropancreatic …

  • 0 views
  • 28 Oct, 2022
  • 5 locations
Personalized PRRT of Neuroendocrine Tumors (P-PRRT)

In this study, peptide receptor radionuclide therapy (PRRT) with 177Lu-Octreotate (LuTate) will be personalized, i.e. administered activity of LuTate will be tailored for each patient to maximize absorbed radiation dose to tumor, while limiting that to healthy organs. The purpose of this study is to: Assess the objective (radiological), symptomatic …

somatostatin
positron emission tomography
pet scan
radionuclide therapy
SPECT Scan
  • 91 views
  • 23 Feb, 2022
  • 1 location
Telotristat Ethyl for the Treatment of Carcinoid Heart Disease in Patients With Metastatic Neuroendocrine Tumor

neuroendocrine tumor that has spread to other places in the body (metastatic). Telotristat ethyl and somatostatin analog therapy may help to control carcinoid syndrome and carcinoid heart disease.

  • 0 views
  • 13 Jul, 2022
  • 1 location
Virtual Reality for GI Cancer Pain to Improve Patient Reported Outcomes

Patients with digestive tract malignancy often experience severe and unremitting abdominal pain that negatively affects physical, emotional, and social function, as well as health related quality of life (HRQOL). Therapeutic virtual reality (VR) has emerged as a promising and evidence-based treatment modality for cancer pain. Users of VR wear a …

opioid
squamous cell carcinoma
adenocarcinoma
carcinoma
cancer pain
  • 0 views
  • 04 Oct, 2022
  • 1 location
Randomized Phase II Trial of Lutetium Lu 177 Dotatate Versus Everolimus in Somatostatin Receptor Positive Bronchial Neuroendocrine Tumors

This phase II trial studies the effect of lutetium Lu 177 dotatate compared to the usual treatment (everolimus) in treating patients with somatostatin receptor positive bronchial neuroendocrine tumors that have spread to other places in the body (advanced). Radioactive drugs, such as lutetium Lu 177 dotatate, may carry radiation directly …

  • 0 views
  • 18 Oct, 2022
  • 5 locations
Survivin Long Peptide Vaccine in Treating Patients With Metastatic Neuroendocrine Tumors

This phase I trial studies the side effects of survivin long peptide vaccine and how it works with the immune system in treating patients with neuroendocrine tumors that have spread to other parts of the body (metastatic). Tumor cells make proteins that are not usually produced by normal cells. The …

  • 12 views
  • 04 Oct, 2022
  • 1 location
Prophylactic Cholecystectomy in Midgut NETs Patients Who Require Primary Tumor Surgery. (TNE-IDC-COLE)

The investigators want to study the effectiveness of prophylactic cholecystectomy in patients with midgut neuroendocrine tumor (jejunum, ileum or proximal colon) who require primary tumor surgery. When patients are diagnosed and are tributary to surgical treatment, the tumor might compromise vascularization, and patients need an extensive bowel resection. The patients …

  • 1 views
  • 04 Oct, 2022
  • 1 location