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Found 98 clinical trials
SBRT With Immunotherapy in Early Stage Non-small Cell Lung Cancer: Tolerability and Lung Effects

This is a single arm, multi-centre, phase II open label study of nivolumab with stereotactic body radiotherapy (SBRT) for early stage non-small cell lung cancer. SBRT will be delivered in either 3 or 5 fractions. A flat dose of 240 mg nivolumab infusion will begin after the final fraction of …

  • 0 views
  • 24 Jan, 2021
  • 1 location
Smartphone Based Smoking Cessation Intervention

Smoking is becoming increasingly concentrated among individuals with the lowest levels of income, education, and occupational status. In fact, smoking rates in the United States among people living below the poverty line is nearly twice as high as those above the poverty threshold. Highly flexible and low burden technology-based treatment …

ecological momentary assessment
smoking cessation intervention
nicotine replacement
  • 40 views
  • 12 Feb, 2021
  • 1 location
Cardiovascular Effects of Pulmonary Rehabilitation in COPD

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, which is clinically manifested by dyspnea and leads the patient to a vicious cycle of sedentary lifestyle. Pulmonary rehabilitation (PR) is an important therapeutic strategy to break this cycle. Cardiovascular diseases are frequent in patients with (COPD) and are …

dyspnea
obstruction
pulmonary rehabilitation
  • 3 views
  • 25 Jan, 2021
  • 2 locations
An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures

Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. Recently, the investigators have evaluated the efficacy of the intravenous administration of 1000/200 mg of amoxicillin/clavulanate for the prevention of bacteraemia following dental extractions. …

anesthesia
antibiotics
amoxicillin
antibiotic therapy
tooth extraction
  • 4 views
  • 09 May, 2021
  • 2 locations
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia

The aim of this study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen supply and better oxygen control than manually controlled oxygen therapy for patients admitted to the emergency department with acute hypoxemia. Furthermore it will be tested if O2matic compared to manual …

oxygen supplementation
hypoxic respiratory failure
respiratory failure
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone

Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease characterized by unpredictable changes with variable kinetics of progression. Changes in pulmonary function (FVC, DLCO) assessed at the time of diagnosis, or decline in pulmonary function within 12 months after diagnosis, are the best predictors of survival, but poorly …

pulmonary disease
pirfenidone
idiopathic pulmonary fibrosis
pulmonary function test
positron emission tomography
  • 6 views
  • 24 Jan, 2021
  • 2 locations
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection

In the presented project, the role of heme oxygenase 1 and 2 in the procesess associated with fibroproduction in the chronic HCV infection will be studied. Heme oxygenase expression will be evaluated by the techniques of molecular genetics and immunohistochemistry, both in the liver tissue and in peripheral blood mononuclear …

antiviral
hepatocellular damage
  • 7 views
  • 07 Nov, 2020
  • 1 location
Brain Imaging in Tobacco Smokers During a Quit Attempt

The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in 7 nicotinic acetylcholine receptor (nAChR) availability when compared to matched historical controls using positron emission tomography (PET) imaging and the radioactive ligand [18F]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6 [18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), an 7 nAChR antagonist. The …

positron emission tomography
carbon monoxide
cotinine
nicotine product
brain imaging
  • 19 views
  • 13 Jun, 2021
  • 1 location
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

fibrosis
prednisone
MRSS
systemic sclerosis
mesna
  • 176 views
  • 27 Jan, 2021
  • 2 locations
JUUL vs. Mod E-cigarette Study

Some smokers who try e-cigarettes transition completely from cigarettes to e-cigarettes, but others continue to use both products, or abandon e-cigarettes and return completely to cigarettes. One factor that likely impacts these tobacco use patterns is the e-cigarette device used. The majority of e-cigarettes purchased today are one of two …

cigarette smoke
tobacco smoke
nicotine product
  • 19 views
  • 25 Jan, 2021
  • 1 location