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Found 96 clinical trials
Role of Heme Oxygenase in the Pathogenesis of Hepatocellular Injury in Chronic Hepatitis C Virus (HCV) Infection

In the presented project, the role of heme oxygenase 1 and 2 in the procesess associated with fibroproduction in the chronic HCV infection will be studied. Heme oxygenase expression will be evaluated by the techniques of molecular genetics and immunohistochemistry, both in the liver tissue and in peripheral blood mononuclear …

antiviral
hepatocellular damage
  • 7 views
  • 07 Nov, 2020
  • 1 location
Brain Imaging in Tobacco Smokers During a Quit Attempt

The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in 7 nicotinic acetylcholine receptor (nAChR) availability when compared to matched historical controls using positron emission tomography (PET) imaging and the radioactive ligand [18F]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6 [18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), an 7 nAChR antagonist. The …

pet imaging
brain imaging
positron emission tomography
carbon monoxide
nicotine product
  • 19 views
  • 24 Jan, 2021
  • 1 location
Evolution of Lung 18FDG Uptake in Patients With Idiopathic Pulmonary Fibrosis and Receiving Pirfenidone

Idiopathic pulmonary fibrosis (IPF) is a rare and fatal lung disease characterized by unpredictable changes with variable kinetics of progression. Changes in pulmonary function (FVC, DLCO) assessed at the time of diagnosis, or decline in pulmonary function within 12 months after diagnosis, are the best predictors of survival, but poorly …

pirfenidone
pulmonary disease
positron emission tomography
idiopathic pulmonary fibrosis
pulmonary function test
  • 6 views
  • 24 Jan, 2021
  • 2 locations
JUUL vs. Mod E-cigarette Study

Some smokers who try e-cigarettes transition completely from cigarettes to e-cigarettes, but others continue to use both products, or abandon e-cigarettes and return completely to cigarettes. One factor that likely impacts these tobacco use patterns is the e-cigarette device used. The majority of e-cigarettes purchased today are one of two …

cigarette smoke
nicotine product
tobacco smoke
  • 19 views
  • 25 Jan, 2021
  • 1 location
Automated Oxygen Control by O2matic to Patients Admitted With Acute Hypoxemia

The aim of this study is to examine if automated oxygen delivery with O2matic allows for faster weaning from oxygen supply and better oxygen control than manually controlled oxygen therapy for patients admitted to the emergency department with acute hypoxemia. Furthermore it will be tested if O2matic compared to manual …

respiratory failure
oxygen supplementation
hypoxic respiratory failure
  • 0 views
  • 25 Jan, 2021
  • 2 locations
Autologous Stem Cell Transplantation in Patients With Systemic Sclerosis

The purpose of this study is to determine whether a regimen of high-dose immunoablative therapy will demonstrate safety that is consistent or improved with other published regimens in SSc patients, while maintaining a treatment effect. We also hypothesize that our mechanistic studies will yield biomarkers that may herald disease recurrence …

intravenous immunoglobulin
prednisone
cyclophosphamide
ct scan
stem cell transplantation
  • 176 views
  • 27 Jan, 2021
  • 2 locations
Cardiovascular Effects of Pulmonary Rehabilitation in COPD

Introduction: Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction, which is clinically manifested by dyspnea and leads the patient to a vicious cycle of sedentary lifestyle. Pulmonary rehabilitation (PR) is an important therapeutic strategy to break this cycle. Cardiovascular diseases are frequent in patients with (COPD) and are …

obstruction
pulmonary rehabilitation
dyspnea
  • 3 views
  • 25 Jan, 2021
  • 2 locations
Coorticosteroid Regimen in Patients With Anti-PD-1/PD-L1 Induced Pneumonitis

This is a prospective interventional open-label randomized trial. The patients treated with anti- PD-1 (programmed-death receptor type 1) or anti-PD-L1 (programmed-death ligand) antibodies in case of new acute onset interstitial changes or new seriuos respiratory system related symptoms will be recruited for this study to perform diagnostics. At the recruitment …

cyclophosphamide
respiratory disease
prednisone
infliximab
diagnostic procedures
  • 8 views
  • 23 Jan, 2021
  • 1 location
Sodium Thiosulfate to Preserve Cardiac Function in STEMI

Rationale: Timely and effective reperfusion by primary percutaneous coronary intervention (PPCI) is currently the most effective treatment of ST-segment elevation myocardial infarction (STEMI). However, permanent myocardial injury related to the ischemia and subsequent reperfusion is observed in the vast majority (88%) of patients and harbours a risk of heart failure …

left bundle branch block
clot
percutaneous coronary intervention
coronary angioplasty
reperfusion therapy
  • 0 views
  • 26 Feb, 2021
  • 3 locations
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature

Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). …

  • 0 views
  • 23 Jan, 2021
  • 2 locations