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Found 81 clinical trials
Brain Imaging in Tobacco Smokers During a Quit Attempt

The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in 7 nicotinic acetylcholine receptor (nAChR) availability when compared to matched historical controls using positron emission tomography (PET) imaging and the radioactive ligand [18F]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6 [18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), an 7 nAChR antagonist. The …

brain imaging
carbon monoxide
positron emission tomography
nicotine product
Accepts healthy volunteers
  • 19 views
  • 15 Feb, 2022
  • 1 location
Effects of Cognitive-behavioral Education and Exercise Interventions on Smoking Cessation

The purpose of the study is to adopt the Trans-theoretical Model to facilitate step-by-step changes in a patient's smoking behavior and explore the effect of "Cognitive-Behavioral Education Course" and "Exercise Program" on Smoking cessation, physical health, and mental health of smokers with CAD.

  • 0 views
  • 20 Oct, 2021
  • 1 location
Smoking, Stress, and Mobile Technology

We seek to refine and evaluate the novel mobile intervention, Mobile Anxiety Sensitivity Program for Smoking (MASP) which was initially developed and previously tested by our team, targeting sensitivity to interoceptive stress, and to apply it among African American smokers. Our culturally adapted intervention is framed within a sociocultural context …

Accepts healthy volunteers
  • 0 views
  • 09 Mar, 2022
  • 2 locations
Mobile App for Smoking Cessation and Mental Health (Smart-T MH)

Adults with serious mental illness (SMI) represent 5% of the United States population, yet account for 30% of all cigarettes smoked and are 2 to 3 times more likely to be dependent on nicotine compared with the general population. There are also significant disparities in quitting: 24% of lifetime smokers …

Accepts healthy volunteers
tobacco smoke
ecological momentary assessment
nicotine replacement
cancer
  • 0 views
  • 21 Apr, 2022
  • 1 location
Acute Exposure to Diesel: Prolong Effects on Inflammation and Vasculature

Cross-over double-blind study. Healthy subjects will be exposed to diesel exhaust fumes and/or filtered air during a 2-hour session. Several parameters will be assesed i.e. endothelial function will be assessed with flow mediated dilation (FMD) techniques, arterial stiffness with pulse wave velocity (PWV) and reflected waves with augmentation index (AIx). …

  • 0 views
  • 23 Jan, 2021
  • 2 locations
The Effect of Inhaled Nitric Oxide on Deadspace in COPD

Chronic obstructive pulmonary disease (COPD) is a progressive disease of the respiratory system that generally develops as a result of smoking. Most people with COPD are classified as having "mild" disease severity and may not have significantly impaired lung function (e.g. flow) as measured by traditional lung function tests. However, …

  • 0 views
  • 04 Oct, 2021
  • 1 location
Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use

The investigators aim to (1) establish a methodology for the evaluation of the biodistribution of radio-labeled nicotine following e-cigarette use, (2) determine the oral/pulmonary distribution of nicotine following e-cigarette use, and (3) determine the lowest required dose using the new digital PET/CT technology to provide detailed or accurate oral/pulmonary distribution …

Accepts healthy volunteers
  • 11 views
  • 01 May, 2022
  • 1 location
Heat Therapy in Older Hypertensive Women

The prevalence of hypertension is greater in older women than men, while the blood pressure (BP) control rate is lower in older women in US. Uncontrolled hypertension is a major risk factor for cardiovascular morbidity/mortality. Despite standard therapy and adherence to optimal drug regimens, >50% of older hypertensive women still …

  • 71 views
  • 06 Feb, 2022
  • 1 location
Effectiveness of Ecological Momentary Assessment Based Smoking Cessation Intervention

The EMA-based intervention in this proposal is aimed to motivate the majority of smokers who do not prefer to use traditional cessation aids for quitting and help them quit smoking. The smartphone application (app) and the EMA-based phone reminders at low cost and short intervention time make this approach attractive …

carbon monoxide
smoking cessation intervention
Accepts healthy volunteers
nicotine replacement
ecological momentary assessment
  • 0 views
  • 22 Mar, 2022
  • 1 location
The Interplay Between Addiction to Tobacco Smoking and Sleep Quality Among Healthy Adults

Tobacco smoking is a major health problem, leading to considerable morbidity and mortality due to cancer, impaired pulmonary function, and cardiovascular diseases. Chronic nicotine consumption related to smoking may affect pulmonary function and can cause neuronal alterations leading to increased emotional distress and decreased cognitive functioning, especially when the smoker …

poor sleep
Accepts healthy volunteers
cotinine
addiction
tobacco smoke
  • 73 views
  • 26 Feb, 2022
  • 1 location