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Found 100 clinical trials
Personalized Dosing of Nicotine Replacement (NRT to Effect)

Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive, so there is much interest in optimizing the effectiveness of existing treatments and medications. Current standard doses of nicotine replacement therapy (NRT) are not effective for many smokers and …

nicotine patch
nicotine replacement
smoking cessation therapy
nicotine product
  • 20 Jun, 2021
  • 3 locations
The Role of Nicotine and Non-Nicotine Alkaloids in E-Cigarette Use and Dependence

The advent of electronic cigarette (e-cigarette) technologies represents one of the most significant developments in the last several decades, and provides a novel and promising strategy for substantially reducing the morbidity and mortality associated with smoking. However, serious concerns have been raised regarding the possibility that e-cigarettes will sustain a …

tobacco product
smoke tobacco
drugs of abuse
tobacco smoke
nicotine product
  • 04 Jun, 2021
  • 1 location
Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients

The purpose of this study is to determine whether oral sildenafil citrate reduces the abnormal right ventricular pressure response during exercise in adolescent and adult patients with specific types of congenital heart defects.

ventricular septal defect
septal defect
congenital heart defects
  • 07 Nov, 2020
  • 1 location
Effect of the SCOT-HEART 2 Trial on Lifestyle.

This study will recruit 400 participants who are taking part in the Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (SCOT-HEART 2) trial. The investigator will assess diet, activity and habits at the start of the study and 6 months later. This will help us understand the effects …

  • 27 Jan, 2021
  • 1 location
Phase 1/2 Study of SBRT With or Without GC4711 for NSCLC

GTI-4711-101 is a Phase 1-2 study of the safety of GC4711, and its potential to reduce radiation-related pulmonary injury due to SBRT for early stage large or central localized NSCLC. After an open-label, Phase 1, safety cohort of approximately 5 subjects has been completed, a randomized, double-blind, placebo-controlled Phase 2 …

measurable disease
  • 27 May, 2021
  • 4 locations
Helping Youth Smokers Stop Smoking Through the Youth Quitline Programme

The aims of the present study are: To raise the awareness of smoking cessation service among youth smokers in Hong Kong; To provide smoking cessation quitline service to youth smokers; and To provide training to teenagers as peer smoking cessation counsellors. To examine the effectiveness of adventure-based training and WhatsApp …

  • 26 Jan, 2021
  • 1 location
Pilot Study to Evaluate the Safety Tolerability and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19

This is an open-label, interventional exploratory study to evaluate the safety and efficacy of 5-ALA-Phosphate + SFC in subjects with acute moderate or severe respiratory illness secondary to infection with SARS-CoV-2 virus (COVID-19) involving 40 subjects. The primary objective is to evaluate the safety of 4-week oral administration of 5-ALAPhosphate …

  • 05 Mar, 2021
  • 2 locations
Effects of Filter Ventilation and Ventilation Information on Product Use Behaviors in Cigarette Smokers

This clinical trial collects data to see how filter ventilation and ventilation information affects product use behaviors in cigarette smokers. Providing ventilation information on the cigarette package may affect smokers' rating of product appeal, perceptions of health risk, and changes in cigarette consumption.

  • 19 Mar, 2021
  • 1 location
Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children

Ascites in liver cirrhosis is explained by increased production of vasoactive substances leading to renal vasoconstriction and salt and water retention. The retained water then accumulates in the peritoneal cavity under the effect of portal hypertension and low albumin. Refractory ascites is defined as ascites that cannot be mobilized or …

  • 24 Jan, 2021
  • 1 location
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment

Smoking cessation has been shown to improve the effectiveness and reduce the morbidity of tobacco-related cancer treatments. We will identify effective smoking cessation strategies for patients who are receiving treatment for tobacco-related cancer. In this trial, patients' preferences in smoking cessation therapy will be the principal determinant by providers in …

  • 03 Feb, 2021
  • 1 location