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Found 96 clinical trials
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial

Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.

  • 19 Feb, 2021
  • 1 location
Comparative Abuse Liability Among African American and White Smokers

The study is a randomized crossover trial. Current smokers will complete a session with each product: usual brand cigarette, e-cigarette, and heat-not-burn. The objective of this survey is to assess for ongoing use of study products and is part of safety monitoring.

  • 26 Jan, 2021
  • 1 location
Xenon-129 Magnetic Resonance Imaging of Healthy Subjects: Hardware and Software Development and Reproducibility

Healthy volunteers aged 18-85 will undergo hyperpolarized 129-Xe MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.

  • 23 Jan, 2021
  • 1 location
129 Xenon MRI in Chronic Lung Disease

Subjects aged 18-85 with lung disease will undergo hyperpolarized Xenon 129 (129-Xe) MRI and Pulmonary Function testing for the development of tools to evaluate the Apparent Diffusion Coefficient (ADC) and ventilation defect volume obtained by analysis of hyperpolarized 129-Xe MRI.

forced expiratory volume
chronic obstructive pulmonary disease
pulmonary function test
  • 26 Jan, 2021
  • 1 location
Reversibility by Sildenafil of Exercise-Induced Abnormal Right Ventricular Pressure Response in ASD and VSD-Operated Patients

The purpose of this study is to determine whether oral sildenafil citrate reduces the abnormal right ventricular pressure response during exercise in adolescent and adult patients with specific types of congenital heart defects.

ventricular septal defect
congenital heart defects
septal defect
  • 07 Nov, 2020
  • 1 location
Reducing Exercise-induced Bronchoconstriction in Children With Asthma and Obesity

In obese children, excess fat exerts an increased mechanical burden on the respiratory system, particularly during exercise. It is unclear whether this burden reduces respiratory function and exercise tolerance and increases severity of exercise-induced bronchoconstriction in obese asthmatic children. The investigators propose that most of the respiratory effects in obese …

metabolic disorders
body mass index
  • 23 Jan, 2021
  • 1 location
Phase 1/2 Study of SBRT With or Without GC4711 for NSCLC

GTI-4711-101 is a Phase 1-2 study of the safety of GC4711, and its potential to reduce radiation-related pulmonary injury due to SBRT for early stage large or central localized NSCLC. After an open-label, Phase 1, safety cohort of approximately 5 subjects has been completed, a randomized, double-blind, placebo-controlled Phase 2 …

  • 18 Feb, 2021
  • 2 locations
Safety and Efficacy of Midodrine Hydrochloride in the Management of Refractory Ascites Due to Cirrhosis in Children

Ascites in liver cirrhosis is explained by increased production of vasoactive substances leading to renal vasoconstriction and salt and water retention. The retained water then accumulates in the peritoneal cavity under the effect of portal hypertension and low albumin. Refractory ascites is defined as ascites that cannot be mobilized or …

  • 24 Jan, 2021
  • 1 location
Effect of the SCOT-HEART 2 Trial on Lifestyle.

This study will recruit 400 participants who are taking part in the Computed Tomography Coronary Angiography for the Prevention of Myocardial Infarction (SCOT-HEART 2) trial. The investigator will assess diet, activity and habits at the start of the study and 6 months later. This will help us understand the effects …

  • 27 Jan, 2021
  • 1 location
Pilot Study to Evaluate the Safety Tolerability and Efficacy of 5-ALA-Phosphate + SFC in Subjects With COVID-19

This is an open-label, interventional exploratory study to evaluate the safety and efficacy of 5-ALA-Phosphate + SFC in subjects with acute moderate or severe respiratory illness secondary to infection with SARS-CoV-2 virus (COVID-19) involving 40 subjects. The primary objective is to evaluate the safety of 4-week oral administration of 5-ALAPhosphate …

  • 28 Jan, 2021
  • 1 location