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Found 81 clinical trials
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders

, breath carbon monoxide (CO), biomarkers of tobacco toxicant exposure, brain function and structure, and airway inflammation (fractional nitric oxide concentration in exhaled breath [FeNO]).

nitric oxide
affective disorder
psychiatric symptoms
nicotine product
  • 23 May, 2021
  • 2 locations
COVID-19 Pneumonia: Pulmonary Physiology Health-related Quality of Life and Benefit of a Rehabilitation Program

, pulmonary function testing, diffusing capacity for carbon monoxide, maximal inspiratory pressure and sniff nasal inspiratory pressure. Those with at least one abnormal value will be invited to fill the

  • 16 May, 2021
  • 1 location
Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder

, withdrawal, psychiatric symptoms, breath carbon monoxide (CO), biomarkers of tobacco toxicant exposure, brain function and structure, and airway inflammation (fractional nitric oxide concentration in exhaled

  • 16 Apr, 2021
  • 3 locations
CORE: CO Monitoring for Reach and Efficacy in Tobacco Treatment for Cancer Patients

The purpose of this study is to assess the cessation success rates of an intensive tobacco treatment program in a patients undergoing cancer treatment at 30 days, 3 months and 6 months.

primary cancer
cancer treatment
carbon monoxide
  • 25 Mar, 2022
  • 1 location
Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment

This research study will evaluate the preliminary efficacy of Pride Posts Plus, a social media-based smoking cessation treatment. A pilot randomized trial (N=120) will compare Pride Posts Plus, which includes a gamification element, to Pride Posts (without gamification) and to a usual care treatment. Participants will be adults who smoke, …

smoking cessation therapy
nicotine product
nicotine gum
nicotine lozenge
smoke tobacco
  • 18 Sep, 2021
  • 2 locations
The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial

Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis. Subjects will be treated with Nintedanib 150mg twice daily for 3 years.

  • 19 Feb, 2021
  • 1 location
Xenon-129 Magnetic Resonance Imaging of Healthy Subjects: Hardware and Software Development and Reproducibility

Healthy volunteers aged 18-85 will undergo hyperpolarized 129-Xe MRI and pulmonary function testing for the development of tools to assess image signal to noise and reproducibility of spin-density and diffusion-weighted imaging.

  • 23 Jan, 2021
  • 1 location
Personalized Dosing of Nicotine Replacement (NRT to Effect)

Medications for smoking cessation are currently only effective in helping a minority of smokers quit. Drug development is slow and expensive, so there is much interest in optimizing the effectiveness of existing treatments and medications. Current standard doses of nicotine replacement therapy (NRT) are not effective for many smokers and …

nicotine product
smoking cessation therapy
nicotine patch
nicotine replacement
  • 02 Mar, 2022
  • 1 location
Telehealth-Filter Ventilation ( COMET2P1 )

The goals of this project are to determine the effects of varying degrees of cigarette filter ventilation on biomarkers of toxicant exposure and smoking behavior and on subjective responses to the cigarette. The primary aim of this study is to examine the effects of unventilated vs ventilated filter cigarettes on …

Accepts healthy volunteers
  • 08 Apr, 2022
  • 2 locations
Methadone-Maintained Smokers Switching to E-Cigarettes (SHINE)

Participants in this randomized clinical trial will be methadone-maintained smokers interested in switching to electronic cigarettes (ECs). There will be a total of 7 study visits over the course of 6 weeks; each visit includes psychometric assessment and biomarker measurements. After completion of the baseline visit, participants will be randomized …

  • 13 May, 2022
  • 1 location