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Found 29 clinical trials
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults

Infection [cIAI]; Bloodstream Infection [BSI]) due to carbapenem-resistant Gram-negative pathogens in China.This study will be an estimation study. The statistical inference will be based on point estimate

ceftazidime-avibactam
carbapenem
fosfomycin
bloodstream infection
abdominal infection
  • 0 views
  • 28 Jun, 2022
  • 10 locations
Imipenem/Cilastatin/Relebactam (IMI/REL) in Treatment of CRE Infections

This is an observation study comparing prospective use of Imipenem/Cilastatin/Relebactam (IMI/REL) to retrospective data using Meropenem/Vabobactam (MVB)and Ceftazidime/Avibactam CZA) in treatment of Klebsiella Producing Carbapenemase Enterobacteriaceae infections at a tertiary care hospital. The objectives of the study are to demonstrate successful treatment of KPC containing Enterobacteriaceae infections with IMI/REL including …

cilastatin
antibiotics
carbapenem
bacteremia
ceftazidime
  • 8 views
  • 02 Jul, 2022
  • 1 location
Temocillin vs Meropenem for the Targeted Treatment of Bacteraemia Resistant to Third Gen Cephalosporins

Belgium and UK) vs a carbapenem antibiotic (meropenem) in adults with bacteraemia due to third-generation cephalosporin-resistant Enterobacteriaceae. The duration of treatment will be between 7 and

cephalosporins
ceftriaxone
antibiotics
carbapenem
ceftazidime
  • 0 views
  • 20 Oct, 2021
  • 32 locations
Temocillin Pharmacokinetics in Paediatrics (TEMOPEDI)

Temocillin (6-methoxy-ticarcillin) is a beta-lactam antibiotic with exceptional resistance to most beta-lactamases. In this context, it is now increasingly used as carbapenem-sparing antibiotic

beta-lactam
temocillin
antibiotics
carbapenem
antibiotic therapy
  • 7 views
  • 15 Jun, 2022
  • 1 location
Safety and Efficacy of Fecal Microbiota Transplantation

encephalopathy, multiple sclerosis, pseudo-obstruction, carbapenem-resistant Enterobacteriaceae (CRE) or Vancomycin-resistant Enterococci (VRE) infection, radiation-induced toxicity, multiple organ dysfunction

irritable bowel syndrome
alcoholic hepatitis
dysbiosis
constipation
fecal microbiota transplantation
  • 427 views
  • 23 Mar, 2022
  • 1 location
Study of the Safety and Pharmacokinetics of KSP-1007 Alone and Coadministered With Meropenem in Healthy Subjects

This study is a first-in-human, Phase 1, randomized, double- blind, four-part, dose-escalation study to assess the safety, tolerability, and pharmacokinetics of single (Part 1) and repeat (Part 2) escalating intravenous doses of KSP-1007. Repeated escalating doses of KSP-1007 will be co-administered with meropenem (Part 3) and single, ascending doses of …

Accepts healthy volunteers
body mass index
  • 0 views
  • 26 Mar, 2022
  • 1 location
SAD/MAD Safety and PK Study of QPX9003 (Novel Polymyxin) in Normal Healthy Volunteers (QPX9003)

The worldwide spread of resistance to antibiotics among gram-negative bacteria, particularly members of the ESKAPE group of pathogens, has resulted in a crisis in the treatment of hospital acquired infections. In particular, the presence of multi-drug resistant Acinetobacter baumannii and Pseudomonas aeruginosa in hospitals around the world poses a considerable …

Accepts healthy volunteers
antibiotics
  • 0 views
  • 25 Mar, 2022
  • 1 location
Dose-finding, Pharmacokinetics, and Safety of VABOMERE in Pediatric Subjects With Bacterial Infections (TANGOKIDS)

A single dose infusion of Vabomere (meropenem-vaborbactam) is being tested for dose-finding, pharmacokinetics, safety, and tolerability in pediatric subjects from birth to less than 18 years of age with serious bacterial infections

antibiotic therapy
absolute neutrophil count
renal function
antibiotics
  • 5 views
  • 26 Jan, 2022
  • 5 locations
Decolonization of Gram-negative Multi-resistant Organisms (MDRO) With Donor Microbiota (FMT)

Colonization by Multiple Drug Resistant Organisms (MDROs) during patient hospitalization requires expensive isolation measures and renders the return or transfer to other departments or institutions often impossible. Currently there is no specific treatment available. Patients have to wait for spontaneous clearance which can take months or does not happen at …

  • 0 views
  • 23 Jan, 2021
  • 1 location
FMT for MDRO Colonization After Infection in Renal Transplant Recipients (PREMIX)

Transplant patients are at increased risk of colonization and infection with Multidrug Resistant Organisms (MDROs) due to medications that modify their immune systems, increased healthcare and antibiotic exposure, and surgical manipulation of mucosa. In this study, kidney transplant patients who have infections with resistant bacteria will be given a Fecal …

  • 78 views
  • 27 Jan, 2022
  • 1 location