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Found 28 clinical trials
Evaluating a Novel Individualised Treatment Strategy for Carbapenem-Resistant Gram-Negative Bacteria Infections

Carbapenem-resistant (CR) Gram negative bacteria (GNB) - which are resistant to carbapenems (a last-line potent antibiotic with a high therapeutic index) - are also resistant to all other beta

  • 29 views
  • 21 Feb, 2022
  • 1 location
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin resistance-conferring rpoB-gene mutations, the combination of meropenem and amoxicillin/clavulanate with rifampin has greater early bactericidal activity (EBA) than the combination of meropenem and amoxicillin/clavulanate …

direct microscopy
amoxicillin
cervical cap
neutrophil count
platelet count
  • 16 views
  • 22 Oct, 2021
  • 1 location
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI (GAMECHANGER)

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

  • 111 views
  • 19 Feb, 2022
  • 9 locations
The Effectiveness of Antimicrobial Breathing System on the Presence of Multidrug-resistant Organisms

The aim of this study is to investigates the effectiveness of antimicrobial breathing system on multidrug-resistant organisms (MDRO).

  • 0 views
  • 25 Nov, 2021
  • 1 location
Seven Versus 14 Days of Antibiotic Therapy for Multidrug-resistant Gram-negative Bacilli Infections (BGN)

Antimicrobial resistance is a major global problem, particularly in hospital-acquired infections (HAIs). Gram-negative bacilli (GNB), including Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter baumannii, are among the most common pathogens associated with multidrug resistance and HAIs. These bacteria are of special concern because few therapeutic options are available. Traditionally, the duration of …

bloodstream infection
antimicrobial agent
antibiotics
antimicrobials
severe infection
  • 0 views
  • 24 Mar, 2022
  • 4 locations
Study to Optimize the Use of New Antibiotics (NEW_SAFE)

carbapenem-resistant Acinetobacter baumannii and Pseudomonas aeruginosa, carbapenem-resistant enterobacteria, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus

isavuconazole
staphylococcus
ceftazidime-avibactam
antibiotics
antimicrobials
  • 3 views
  • 16 Feb, 2022
  • 13 locations
Bolus Versus Continuous Infusion of Meropenem (MERCY)

responsible for 70% of drug-resistant infections acquired in the intensive care unit. Meropenem is a β-lactam, carbapenem, antibacterial agent usually administered by intermittent infusion. As β-lactam

  • 0 views
  • 27 Feb, 2022
  • 20 locations
Fecal Microbiota Transplantation for Carbapenem-resistant Enterobacteriaceae

2:1, open-label, single center, randomized controlled trial comparing FMT vs. no intervention for CRE carriers,

  • 0 views
  • 26 Jan, 2021
  • 1 location
FMT for the Decolonization of Carbapenem-resistant Enterobacteriaceae

eradicating also MDRB, mainly carbapenem-resistant Enterobacteriaceae. However, current evidence is mostly limited to case reports and case series, and to a single randomised trial, which was stopped

  • 0 views
  • 26 Aug, 2021
  • 1 location
Efficacy and Safety of CAZ-AVI in the Treatment of Infections Due to Carbapenem-resistant G- Pathogens in Chinese Adults

Infection [cIAI]; Bloodstream Infection [BSI]) due to carbapenem-resistant Gram-negative pathogens in China.This study will be an estimation study. The statistical inference will be based on point estimate

pneumonia
amikacin
bloodstream infection
abdominal infection
ceftazidime-avibactam
  • 0 views
  • 24 May, 2022
  • 8 locations