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Found 223 clinical trials
Phase I Safety and Feasibility Pilot Study of Same-Day Discharge After Video-Assisted Thoracoscopic Surgery (VATS) Anatomical Lung or Wedge Resection (VALUE Trial) (VALUE)

Phase I to evaluate the safety and feasibility of same-day discharge in selected participants undergoing minimally-invasive lung surgery and who receive an enhanced recovery pathway.

  • 0 views
  • 22 Oct, 2022
  • 1 location
Local Excision Versus Total Mesorectal Excision In Pathological Complete Response (ypT0-1cN0) Mid- Or Low-Rectal Cancer After Neoadjuvant Therapy

Patients with cT2-4aN0-2M0 mid- or low-rectal cancer received neoadjuvant chemotherapy or combined chemoradiotherapy. Good responders (cT0-1N0) patients received local excision 4-8 weeks after treatment. Pathologically verified ypT0-1 patients are randomized to observation (local excision group) or complementary rectal excision (total mesorectal excision group). The composite end points include 3 year …

cancer
adjuvant therapy
obstruction
metastasis
chemoradiotherapy
  • 1 views
  • 04 Mar, 2022
  • 1 location
Lung Surgery With Enhanced Recovery VS. Lung Surgery Without Enhanced Recovery

Objective: The adoption of Enhanced Recovery Surgery programs in lung resection is relatively recent with limited outcome data. This study aimed to determine the impact of an Enhanced Recovery Surgery pathway on short- term and long- term results in patients undergoing lung resection for primary lung cancer. Methods: A Randomized …

cancer
pulmonary resection
lung operation
lung carcinoma
lung cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
The HepatoPancreaticoBiliary Resection Arginine Immunomodulation (PRIMe) Trial (PRIMe)

This is a randomized controlled blinded superiority trial to evaluate the impact of perioperative immunosupplementation on immune function following resection for hepatopancreaticobiliary (HPB) malignancy.

adenocarcinoma
  • 0 views
  • 14 Jun, 2022
  • 2 locations
Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy

This study is a multi-center phase 3 trial to evaluate a treatment strategy for selecting patients who can benefit from the synchronous resection of primary pancreatic cancer and liver oligometastasis after induction chemotherapy. Half of participants who meet the entry criterion will receive surgical intervention, while the other half will …

cancer
fluorouracil
cancer chemotherapy
metastasis
liver metastasis
  • 8 views
  • 15 Feb, 2022
Chemotherapy and Surgical Resection in Patients With Hepatic Oligometastatic Adenocarcinoma of the Pancreas (HOLIPANC)

This is an interventional, open-label, non-randomised, multicentre, single-arm phase II clinical trial. Eligible patients with hepatic oligometastatic adenocarcinoma of the pancreas will receive neoadjuvant combination chemotherapy (liposomal irinotecan, oxaliplatin, 5-fluouracil, folinic acid (NAPOX)) in cycles of 14 days. Patients with tumour response or stable disease and a resectable primary tumour …

cancer chemotherapy
metastasis
neutrophil count
measurable disease
irinotecan
  • 0 views
  • 09 Mar, 2022
  • 5 locations
Impact of a Patient-Centered Program for Low Anterior Resection Syndrome A Multicenter Randomized Controlled Trial

After undergoing restorative proctectomy for rectal cancer, many patients are left with significant bowel dysfunction, known as Low Anterior Resection Syndrome (LARS). Increased LARS severity correlates with worse perceived global health status and quality of life (QoL). Among patients undergoing rectal resection with a permanent ostomy, there is evidence that …

cancer
proctectomy
low anterior resection
rectal carcinoma
  • 0 views
  • 04 Oct, 2022
  • 5 locations
Multicenter Phase II Study of Transanal TME (taTME)

Radical rectal cancer resection, namely total mesorectal excision (TME), is the cornerstone of the treatment of resectable rectal cancer. In combination with chemotherapy and radiation treatment (CRT), complete TME with negative resection margins is associated with sustained local and systemic control even in locally advanced disease. Over the last 2 …

cancer
proctoscopy
metastasis
adenocarcinoma of rectum
total mesorectal excision
  • 20 views
  • 18 Apr, 2022
  • 13 locations
Postoperative Morbidity and Mortality After Gastrectomy for Gastric Cancer: Prospective Cohort Study

cancer surgery, the morbidity of gastric cancer surgery was reported around 20% with less than 1% of mortality in East. In contrast, around 40% of morbidity and 10% of mortality was reported in West

  • 8 views
  • 22 Jan, 2021
  • 1 location
Validation of the French Version of the Low Anterior Resection Syndrome (LARS) Among Rectal Cancer Patients

duration of 24 months after surgery to allow their bowel function to have regained stability. This study will be supported by the French Research Group of Rectal Cancer Surgery in order to allow the

  • 0 views
  • 25 Jan, 2021
  • 8 locations