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Found 390 clinical trials
The Effect of Combined General/Regional Anesthesia on Cancer Recurrence in Patients Having Lung Cancer Resections

The primary hypothesis is that disease-free survival is improved in patients undergoing resection for tumor thought to be stage I-III primary non-small cell lung cancer in patients with combined general-epidural anesthesia & analgesia as compared to patients receiving general anesthesia and postoperative patient-controlled opioid analgesia. Patients having surgery for resection …

lung carcinoma
  • 8 views
  • 25 Mar, 2022
  • 1 location
Intra-Operative Electron Boost and Hypofractionated Whole-Breast Irradiation During Breast-conserving Treatment (BCT)

Title HIOB - Hypofractionated Whole-Breast Irradiation preceded by Intraoperative Radiotherapy with Electrons as anticipated Boost ISIORT- 01 HIOB is defined as hypofractionated WBRT (40,5 Gy in 2,7 Gy per fraction) preceded by an Intraoperative Boost to the tumor bed ( 90 % reference dose of 10 Gy, 11,1 Gy Dmax …

breast irradiation
carcinoma
cancer
breast cancer
  • 0 views
  • 28 Dec, 2021
  • 1 location
A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR

  • 0 views
  • 21 Oct, 2022
  • 424 locations
Accelerated Partial Breast Irradiation With IMRT in Early Breast Cancer

This study is to evaluate the efficacy and toxicity of accelerated partial breast irradiation (ABPI) with intensity modulated radiation therapy (IMRT) in low-risk breast cancer treat with breast-conserving surgery.

breast-conserving surgery
ductal carcinoma in situ
adjuvant chemotherapy
immunostimulant
carcinoma
  • 1 views
  • 23 Mar, 2022
  • 1 location
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery

A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes. The

dexmedetomidine
anesthesia
analgesia
analgesics
metastasis
  • 8 views
  • 30 Apr, 2022
  • 1 location
PSMA-PET Guided Hypofractionated Salvage Prostate Bed Radiotherapy (PERYTON)

After radical prostatectomy approximately 15-40% of men develop a biochemical recurrence (BR) within 5 years. The standard treatment of post-prostatectomy BR is salvage external beam radiation therapy (sEBRT). sEBRT can provide long-term disease control; with 5 year biochemical progression-free survival (bPFS) up to 60% and with most treatment failures in …

  • 0 views
  • 23 Apr, 2022
  • 7 locations
The MASTER Study (MAmmary Cancer STatin ER Positive Study)

Given the compelling evidence supporting a protective effect of statins on breast cancer recurrence, calls for prospective clinical trials have been expressed. In this trial - the MASTER trial

  • 1 views
  • 28 Jan, 2021
  • 1 location
Partial Breast Versus no Irradiation for Women With Early Breast Cancer

All early breast cancer patients are offered adjuvant breast radiation therapy (RT) after breast conserving surgery for an early breast cancer. Breast cancer is heterogeneous, and selected patients have a very low gain from RT, whilst they still have risk of acute and late side effects from RT. This trial …

cancer
breast cancer
  • 10 views
  • 13 Feb, 2022
  • 16 locations
Impact of Remimazolam on Prognosis After Bladder Cancer Surgery

Bladder cancer is one of the most common genitourinary cancers. Transurethral resection of bladder tumor (TURBT) is the standard therapy for nonmuscle invasive bladder cancer. However, patients after TURBT are at risk for recurrence and progression. Benzodiazepines are proved to inhibit proliferation of multiple types of cancer cells in vitro. …

transurethral resection
surgery for bladder cancer
transurethral bladder excision
invasive bladder cancer
bladder tumor
  • 1 views
  • 19 Jul, 2021
  • 6 locations
Effect of Chemoprevention by Low-dose Aspirin of New or Recurrent Colorectal Adenomas in Patients With Lynch Syndrome (AAS-Lynch)

chromo-endoscopy in Lynch syndrome patients. The trial will also explore: (i) colorectal neoplasia recurrence according to different germline alteration in mismatch repair genes, (ii) observance to

acetylsalicylic acid lysinate
adenoma
endoscopy
  • 13 views
  • 08 Jul, 2022
  • 1 location