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Found 673 clinical trials
A Study to Compare Two Surgical Procedures in Women With BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

This trial studies how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for women with BRCA1 mutations

cancer of the ovary
oophorectomy
ca 125
hysterectomy
cancer
  • 98 views
  • 19 Jun, 2022
  • 186 locations
A Phase 3, Randomized, Double-Blind Study of Pembrolizumab Versus Placebo in Combination With Paclitaxel With or Without Bevacizumab for the Treatment of Platinum-resistant Recurrent Ovarian Cancer (KEYNOTE-B96/ENGOT-ov65)

The primary objective is to compare pembrolizumab plus paclitaxel with or without bevacizumab to placebo plus paclitaxel with or without bevacizumab, with respect to progression-free survival (PFS) per Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 as assessed by the investigator. The hypotheses are that pembrolizumab plus paclitaxel with or …

cancer of the ovary
mk-3475
pembrolizumab
paclitaxel
cancer chemotherapy
  • 1 views
  • 24 Oct, 2022
  • 154 locations
Phase III Randomized Clinical Trial for Stage III Epithelial Ovarian Cancer Randomizing Between Primary Cytoreductive Surgery With or Without Hyperthermic Intraperitoneal Chemotherapy (OVHIPEC-2)

stage III epithelial ovarian cancer randomizing between primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy

cancer of the ovary
ovarian epithelial carcinoma
cytoreductive surgery
fallopian tube
intraperitoneal chemotherapy
  • 0 views
  • 24 Oct, 2022
  • 20 locations
Testing a Low Cost Population- and Theory-Based Outreach Intervention to Engage Ovarian Cancer Survivors and Their Close Relatives to Consider Genetic Services

This study tests a multi-component, low cost, message-based communication outreach intervention to engage ovarian cancer survivors and their at-risk relatives in considering cancer genetic

cancer of the ovary
BRCA1/2
BRCA1
Accepts healthy volunteers
fallopian tube
  • 0 views
  • 21 Oct, 2022
  • 1 location
A Phase II, Open-Label, Multicenter, Platform Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors (BOUQUET)

This study will evaluate the efficacy and safety of multiple biomarker-selected treatments in patients with persistent or recurrent rare epithelial ovarian, fallopian tube, or primary peritoneal tumors. Enrollment will take place in two phases: a preliminary phase followed by a potential expansion phase.

cancer of the ovary
peritoneal cancer
ovarian epithelial carcinoma
hormone therapy
ovarian carcinoma
  • 0 views
  • 21 Oct, 2022
  • 55 locations
A Randomised, Double-blind, Placebo-controlled, Phase III Study of Olaparib Maintenance Monotherapy in Participants With BRCA Wild Type Advanced High Grade Serous or Endometrioid Ovarian Cancer Following Response to Standard First-line Platinum-based Chemotherapy (MONO-OLA1) (MONO-OLA1)

participants with Stage III to IV high grade serous or endometroid ovarian cancer (including fallopian tube cancer or primary peritoneal cancer) who are in complete or partial response following treatment with

cancer of the ovary
peritoneal cancer
interval debulking surgery
tumor debulking
platinum-based chemotherapy
  • 1 views
  • 21 Oct, 2022
  • 47 locations
International Phase III Randomised Study to Evaluate the Efficacy of Maintenance Therapy With Olaparib and Cediranib or Olaparib Alone in Patients With Relapsed Ovarian Cancer Following a Response to Platinum-based Chemotherapy (ICON9)

ICON 9 will assess the efficacy, safety and tolerability of maintenance olaparib in combination with cediranib compared to maintenance olaparib alone following a response to platinum-based chemotherapy in women with relapsed platinum-sensitive ovarian, fallopian tube or peritoneal cancer. Prognostic and predictive factors will be studied from tumour and blood samples.

cancer of the ovary
peritoneal cancer
metastasis
recurrent disease
endometrioid carcinoma
  • 416 views
  • 11 Oct, 2022
  • 52 locations
A Randomized, Phase 2 Study of Pembrolizumab And Chemotherapy With or Without MK-4830 as Neoadjuvant Treatment for High-Grade Serous Ovarian Cancer

The primary objective is to evaluate in participants with high-grade serous ovarian cancer (HGSOC), whether the reduction from baseline in circulating tumor DNA (ctDNA) at Cycle 3 (ΔctDNA) is

cancer of the ovary
peritoneal cancer
interval debulking surgery
carboplatin
pembrolizumab
  • 0 views
  • 24 Oct, 2022
  • 26 locations
Hysterectomy and OPPortunistic SAlpingectomy (HOPPSA)

>implies reduced risk of subsequent ovarian cancer Randomization and follow-up will be conducted within national registers.

cancer of the ovary
laparotomy
  • 10 views
  • 31 Jan, 2022
  • 1 location
A Phase 2 Study of VS-6766 (Dual RAF/MEK Inhibitor) Alone and In Combination With Defactinib (FAK Inhibitor) in Recurrent Low-Grade Serous Ovarian Cancer (LGSOC) (RAMP-201)

This study will assess the safety and efficacy of VS-6766 monotherapy and in combination with Defactinib in subjects with recurrent Low-Grade Serous Ovarian Cancer (LGSOC)

cancer of the ovary
measurable disease
KRAS
  • 0 views
  • 12 Oct, 2022
  • 44 locations