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Found 4 clinical trials
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Trial of EP0057 a Nanoparticle Camptothecin With Olaparib in People With Relapsed/Refractory Small Cell Lung Cancer

Background: EP0057 consists of a sugar molecule cyclodextrin linked to a chemotherapy drug called camptothecin. The combined molecule or "nanoparticle drug conjugate" travels through the blood

aptt
renal function test
olaparib
cancer chemotherapy
cancer
  • 194 views
  • 27 Nov, 2021
  • 1 location
None
EP0057 in Combination With Olaparib in Advanced Ovarian Cancer

preferential accumulation of EP0057, and therefore of the payload Camptothecin, to translate into maximum tumour cell killing.

olaparib
neutrophil count
cancer chemotherapy
platinum-based chemotherapy
line of therapy
  • 2 views
  • 16 Nov, 2021
  • 14 locations
None
Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas

Background The new drug LMP744 damages DNA. This causes cell death. Researchers want to see if it can treat certain kinds of cancer. They want to understand how the drug works and how it affects the body. Objective To test the safety of LMP744 and find out the dose of …

solid tumour
neutrophil count
nitrosoureas
white blood cells
cancer
  • 45 views
  • 26 Oct, 2021
  • 2 locations
None
A Phase I/II Study of Sacituzumab Govitecan Plus Berzosertib in Small Cell Lung Cancer and Homologous Recombination-Deficient Cancers Resistant to PARP Inhibitors

Background Small cell lung cancer and PARP inhibitor resistant tumors are aggressive cancers. Current treatments for people with these tumors yield little benefit. Researchers want to see if a combination of drugs can help. Objective To find a safe combination of sacituzumab govitecan and berzosertib and to see if this …

kinase inhibitor
brain metastases
metastasis
neutrophil count
cancer chemotherapy
  • 0 views
  • 08 Dec, 2021
  • 1 location