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Found 8 clinical trials
Featured trial
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background: Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective: To see if a new transplant regime is effective, safe and well …

cell transplantation
red blood cell disorder
stroke
sickle cell disease
  • 83 views
  • 22 Dec, 2020
  • 1 location
A Monoclonal Antibody Conditioning Regimen for Allogeneic Stem Cell Transplant in Patients With Fanconi Anemia.

. Instead of the high dose chemotherapy usually given before a transplant, this research study uses a new pre-treatment combination of two drugs, Anti-CD45 and CAMPATH-1H. Anti-CD45 and CAMPATH-1H

campath
fludarabine
anemia
graft versus host disease
  • 44 views
  • 07 Nov, 2020
  • 1 location
Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases

The hypothesis for this study is that a preparative regimen that maximizes host immunosuppression without myeloablation will be well tolerated and sufficient for engraftment of donor hematopoietic cells. It is also to determine major toxicities from these conditioning regimens, within the first 100 days after transplantation.

campath
methotrexate
melphalan
hydroxyurea
graft versus host disease
  • 142 views
  • 24 Jan, 2022
  • 20 locations
Islet Cell Transplant for Type 1 Diabetes (TCD)

produce insulin, which can improve blood sugar control and eliminate the need to inject insulin or use an insulin pump. Anti-thymocyte globulin (ATG) and alemtuzumab (Campath) are anti-rejection

hypoglycemia
kidney transplant
insulin
hypoglycaemia unawareness
injection of insulin
  • 838 views
  • 21 Mar, 2022
  • 1 location
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias

days; then his or her stem cells will be collected and frozen one month prior to BMT. Approximately one month later, the patient will be given two immune-suppressing drugs, Campath 1-H and Sirolimus

Accepts healthy volunteers
vaso-occlusive crisis
campath
anemia
alloimmunization
  • 95 views
  • 18 Jun, 2022
  • 1 location
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant Disorders (RIC)

This is a Phase II pilot study to evaluate engraftment and toxicity of patients with non-malignant diseases using a reduced intensity conditioning regimen in the setting of allogeneic transplant for non malignant diseases. Bone Marrow or cord blood will be acceptable as a stem cell source. Recently, reduced intensity conditioning …

campath
histiocytosis
busulfan
transplant conditioning
reduced intensity conditioning
  • 1 views
  • 08 Apr, 2022
  • 1 location
High Dose Peripheral Blood Stem Cell Transplantation With Post Transplant Cyclophosphamide for Patients With Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) affects white blood cell function. Currently, the only curative treatment is bone marrow transplant to replace the abnormal stem cells with new ones (donor cells) capable of making a normal immune system. Transplant problems include graft versus host disease (GvHD) and graft rejection. With GvHD, donor …

  • 3 views
  • 18 Apr, 2022
  • 1 location
Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease

Background Peripheral blood stem cell transplantation procedures are used for people with sickle cell disease. Researchers want to improve the success and reduce the complications for these procedures. This might allow more people to have a transplant. Objective To see if a new transplant regime is effective, safe and well …

Accepts healthy volunteers
campath
hydroxyurea
cell transplantation
sirolimus
  • 2 views
  • 17 Jun, 2022
  • 1 location