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Found 33 clinical trials
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A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background: People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

aplastic anemia
myelodysplastic syndromes
anemia
anemia studies
myelodysplastic syndrome (mds)
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Investigational Product in Patients With Rheumatoid Arthritis (RA) With or Without Background Disease-Modifying Anti-rheumatic Drug (DMARD) Therapy

  • 156 views
  • 08 Nov, 2020
  • 1 location
Calcineurin Inhibitor (CNI) Versus Steroid Cessation in Renal Transplantation

This study intends to determine whether steroid withdrawal or calcineurin inhibitor withdrawal is superior for graft function and graft survival. Secondary endpoints for this study are

cyclosporine
calcineurin inhibitor
everolimus
myfortic
  • 18 views
  • 07 Nov, 2020
  • 4 locations
Safety Study of Calcineurin Inhibitor Free GvHD Prophylaxis in Allogeneic Stem Cell Transplantation

In stem cell transplantation as treatment for malignant diseases, calcineurin inhibitors like cyclosporine A are commonly used to prevent tissue destruction (GvHD) by activated donor immune cells. The hypothesis for this study is, that replacing calcineurin inhibitors by everolimus and mycophenolate as GvHD prophylaxis not only reduces toxicity of the …

hodgkin's disease
hematologic malignancy
chronic myelomonocytic leukaemia
blast crisis
cancer
  • 9 views
  • 07 Nov, 2020
  • 1 location
Viral Load Guided Immunosuppression After Lung Transplantation

of Torque-Teno-Virus (TTV). The aim of the study is to investigate an individual adaptation of the calcineurin inhibitor tacrolimus (tailored calcineurin inhibitor dosing) by a non-invasive biomarker

  • 0 views
  • 26 Jan, 2021
  • 2 locations
Gastrointestinal Tolerability of MMF vs EC-MPS in Maintenance Transplant Patients Treated With Calcineurin Inhibitors

The purpose of the study is to assess the gastrointestinal tolerability of EC-MPS compared to MMF in maintenance transplant patients on a calcineurin inhibitor regimen, who require MMF

calcineurin inhibitor
pancreas transplants
immunosuppressants
cyclosporine
tacrolimus
  • 7 views
  • 07 Nov, 2020
  • 1 location
Safety and Tolerance of Immunomodulating Therapy With Donor-specific MSC in Pediatric Living-Donor Liver Transplantation

Since the introduction of calcineurin-based immunosuppression, patient and graft survival in pediatric liver transplantation (LT) improved significantly. However, in contrast, calcineurin

  • 9 views
  • 22 Jan, 2021
  • 1 location
Bioavailability and Practicability of Envarsus Versus Advagraf in Liver Transplant Recipients

(comparator arm) as first-line calcineurin inhibitor within a standard-of-care immunosuppressive regimen. Tacrolimus blood trough levels and drug doses are monitored at regular intervals to assess drug

  • 0 views
  • 03 Feb, 2021
  • 12 locations
Efficiency of Everolimus for the Treatment of Kidney Transplanted Patients Presenting a Missing Self-induced NK-mediated Rejection

missing self on their graft responsible for a NK-mediated rejection will be established prospectively. An mTOR inhibitor will be introduced in these patients for 6 months in association with a calcineurin

  • 0 views
  • 03 May, 2021
  • 1 location
Bioequivalence Study of Tacrolimus in Healthy Volunteers

This is an in-vivo study to investigate the bioequivalence of generic tacrolimus and its reference listed drug (RLD). The objective of this study is to investigate the bioequivalence of generic Tacrolimus and RLD in healthy male and non-pregnant, non-lactating female volunteers under fasting conditions. The outcome of this study will …

  • 0 views
  • 24 Mar, 2021
  • 1 location