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Found 62 clinical trials
Effect of Metabolic Control at Onset of Diabetes on Progression of Type 1 Diabetes

The aim of this study is to determine if early and tight restoration of metabolic control at the onset of Type 1 diabetes (T1DM) will improve insulin secretion (C-peptide production

  • 07 Nov, 2020
  • 3 locations
Effects of GABAA Receptor Modulation by AP-325 on Insulin Secretion in Patients With Type 2 Diabetes

on C-peptide release as measure of insulin secretion compared to placebo in type 2 diabetes (T2D) patients.

  • 22 Mar, 2022
  • 1 location
ENSO 16 - Study in Healthy Subjects

female subjects at defined time points (0 - 15 - 30 - 45 - 60 - 90 - 120 180 minutes; 3 min at each time point). Individual plasma glucose, insulin and C-peptide concentrations are going to

Accepts healthy volunteers
  • 25 Jul, 2022
CIRTEN-Simultaneous Pancreas-Kidney Transplant Recipients

This is a Phase II/III, Single-center, Prospective, Open-label, Single Arm Study of 30 Simultaneous Kidney Pancreas recipients who received a transplant at least 3 months, but no more than 5 years prior, with a history of tremors following transplantation.

  • 21 Apr, 2022
  • 1 location
Effect of Physiologic Hyperglucogonemia on Adipocyte Metabolism (Glucagon)

Purpose/Objectives: To investigate the effect of hyperglucagonemia on insulin action, particularly on adipose tissue. Research Design/Plan: Normal glucose tolerant subjects will be studied. Study subjects will receive a continuous glucagon infusion for 12 hours. Following glucagon infusion, subjects will receive prime-continuous tracer infusions for additional 4 hours to measure adipocyte …

Accepts healthy volunteers
  • 01 Mar, 2022
  • 2 locations
Feasibility of Low Energy Diet in HFpEF and Type 2 Diabetes (ALLEVIATE)

Open, Single arm intervention, feasibility study

  • 09 Jun, 2022
  • 1 location
Managing DIabetes Remission After Combined Therapy in EarLy Stage of DiabetEs

Epidemiologic, social and economic burdens of type 2 diabetes mellitus (T2DM) keep rising worldwide. Implementation of T2DM preventive trategies is lagging behind. Metabolic surgery, very low calorie diet can induce T2DM remission, but so far for few patients. The investigators will assess the efficacy to cause T2DM remission (primary end …

  • 23 Aug, 2021
  • 1 location
MELD-ATG: Phase II, Dose Ranging, Efficacy Study of Anti-thymocyte Globulin (ATG) Within 6 Weeks of Diagnosis of Type 1 Diabetes (T1D) (Meld-ATG)

stimulated C-peptide at 12 months compared to placebo to identify the minimally effective dose of ATG that shows an effect on C-peptide when compared to placebo at 12 months

  • 17 Mar, 2022
  • 5 locations
The Effect of Early Screening and Intervention for Gestational Diabetes Mellitus on Pregnancy Outcomes (TESGO)

Outcome Measure: The primary outcome is a composite measure of pregnancy outcomes, including primary CS, birth weight >90th percentile, neonatal hypoglycemia, cord serum C-peptide >90th percentile

birth trauma
Accepts healthy volunteers
  • 21 Jul, 2022
  • 1 location
Verapamil SR in Adults With Type 1 Diabetes (Ver-A-T1D)

This study has been set up within the framework of the INNODIA network. INNODIA is a global partnership between 31 academic institutions, 6 industrial partners, a small sized enterprise and 2 patient organizations, bringing their knowledge and experience together with one common goal: "To fight type 1 diabetes". ( The …

  • 28 Jul, 2022
  • 21 locations