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Found 64 clinical trials
Phase II Trial of Allogeneic Hematopoietic Cell Transplantation for Disorders of T-cell Proliferation and/or Dysregulation

Background Blood stem cells in the bone marrow make all the cells to normally defend a body against disease. Allogeneic blood or marrow transplant is when these stem cells are transferred from one person to another. Researchers think this treatment can provide a new, healthy immune system to correct T-cell …

tacrolimus
fever
immune globulin
lymphoproliferative disorder
Accepts healthy volunteers
  • 138 views
  • 25 Oct, 2022
  • 2 locations
A Multi-Center, Phase 2 Gene Transfer Study Inducing Fetal Hemoglobin in Sickle Cell (GRASP, BMT CTN 2001) (GRASP)

A promising approach for the treatment of genetic diseases is called gene therapy. Gene therapy is a relatively new field of medicine in which genetic material (mostly DNA) in the patient is changed to treat his or her own disease. In gene therapy, we introduce new genetic material in order …

bone marrow transplant
sickle hemoglobin
gene therapy
thalassemia
conjugated bilirubin
  • 0 views
  • 23 Oct, 2022
  • 2 locations
Stem Cell Gene Therapy for Cystinosis

This study is a Phase 1/2 clinical trial that will assess the safety and efficacy of enriched gene-corrected hematopoietic stem cells isolated from patients affected with cystinosis. (Investigational Product: CTNS-RD-04 or CTNS-RD-04-LB, where the suffix "-LB" stands for LentiBOOST)

  • 0 views
  • 14 Jun, 2022
  • 1 location
Stem Cell Gene Therapy for Sickle Cell Disease

This Phase I clinical trial will assess the safety and initial evidence for efficacy of an autologous transplant of lentiviral vector modified peripheral blood for adults with severe sickle cell disease.

gene therapy
  • 0 views
  • 20 Apr, 2022
  • 1 location
Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

Background Sickle cell disease can often be treated with blood stem cell transplants. But for some people the disease returns. This study will give a second transplant to people whose disease has returned but still have some donor cells in their body. Objective To cure people s sickle cell disease …

priapism
beta-hcg
g-csf
x-rays
sickle cell trait
  • 12 views
  • 04 Oct, 2022
  • 1 location
Peritransplant Ruxolitinib for Patients With Primary and Secondary Myelofibrosis

This phase II trial studies how well administering ruxolitinib before, during, and after allogeneic hematopoietic stem cell transplantation works in preventing graft versus host disease and improving transplant outcomes in patients with primary and secondary myelofibrosis. Donor hematopoietic stem cell transplantation (HSCT) is currently the only treatment with proven curative …

tacrolimus
mycophenolate mofetil
stem cell transplantation
carbon monoxide
hemolysis
  • 72 views
  • 14 Jul, 2022
  • 1 location
Genetically Engineered PBMC and PBSC Expressing NY-ESO-1 TCR After a Myeloablative Conditioning Regimen to Treat Patients With Advanced Cancer (NYESO SCT)

This phase I clinical trial evaluates the safety and feasibility of administering NY-ESO-1 TCR (T cell receptor)engineered peripheral blood mononuclear cells (PBMC) and peripheral blood stem cells (PBSC) after a myeloablative conditioning regimen to treat patients with cancer that has spread to other parts of the body. The conditioning chemotherapy …

ny-eso-1
ct scan
cancer chemotherapy
metastatic cancer
advanced cancer
  • 9 views
  • 25 Mar, 2022
  • 1 location
A Controlled Multi-Arm Ph1 Study Evaluating the Safety and Feasibility of TCR Engineered Donor TCells Targeting HA1 (TSC-100) or HA2 (TSC-101) in HLA-A0201 Positive Patients Undergoing Haploidentical Allogeneic Stem Cell Transplantation

This is a multi-center, non-randomized, concurrent controlled, multi-arm, Phase 1 interventional, open-label, biologic assignment-based umbrella study evaluating the feasibility, safety and preliminary efficacy of an escalating dose regimen of up to 2 doses of TSC-100 and TSC-101 in patients with AML, MDS, or ALL following HCT from a haploidentical donor.

Accepts healthy volunteers
  • 0 views
  • 20 Oct, 2022
  • 2 locations
Pilot Trial of Allogeneic Blood or Marrow Transplantation for Primary Immunodeficiencies

Background Allogeneic blood or marrow transplant is when stem cells are taken from one person s blood or bone marrow and given to another person. Researchers think this may help people with immune system problems. Objective To see if allogeneic blood or bone marrow transplant is safe and effective in …

vasculitis
lymphoproliferative disorder
vaccination
ct scan
Accepts healthy volunteers
  • 511 views
  • 23 Oct, 2022
  • 2 locations
Safety And Efficacy Of TKI Cessation For CML Patients With Stable Molecular Response In A Real World Population (TOKIN)

This is a single-arm, phase II study to evaluate safety and efficacy of tyrosine kinase inhibitor (TKI) cessation for chronic myeloid leukemia (CML) patients with stable molecular response in a real world population.

bosutinib
remission
tyrosine
dasatinib
leukemia
  • 2 views
  • 25 Mar, 2022
  • 3 locations