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Found 58 clinical trials
A Trial of the Safety and Immunogenicity of the COVID-19 Vaccine (mRNA-1273) in Participants With Hematologic Malignancies and Various Regimens of Immunosuppression, and in Participants With Solid Tumors on PD1/PDL1 Inhibitor Therapy, Including Boost...

Background COVID-19 is a viral infection. It has spread rapidly across the globe. It has overwhelmed health systems. Researchers are concerned that it may undo years of progress in the reduction of cancer-specific death. They want to test a vaccine that might protect people with cancer from COVID-19. Objective To …

leukemia
bilateral oophorectomy
neutrophil count
lymphoma
acute leukemia
  • 16 views
  • 02 Jul, 2022
  • 1 location
Acalabrutinib With DA-EPOCH-R or R-CHOP for People With Untreated Diffuse Large B-cell Lymphoma

Background Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma. Most people with this cancer can be cured. But those who are not cured have a poor prognosis. Researchers want to add another drug to standard treatment see if it can improve the cure rate. Objective To …

leukemia
cyclophosphamide
r-chop
colony stimulating factor
lymphocytic leukemia
  • 2 views
  • 02 Jul, 2022
  • 1 location
Tolebrutinib, a Brain-penetrant Bruton s Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

Background Some multiple sclerosis (MS) lesions stay inflamed for very long periods of time. This type of inflammation is not affected by any MS medications. These lesions can lead to slow worsening of MS symptoms. Researchers want to see if a new drug can help. Objective To see if tolebrutinib …

ocrelizumab
rituximab
MRI
  • 0 views
  • 27 Jun, 2022
  • 1 location
RMS Study of BTK Inhibitor SAR442168

To access SAR442168 in the RMS populstion. Efficaty will be accessed by adjudicated relapse rate, disability progression, and MRI findings of disease activity.

  • 0 views
  • 21 Jul, 2021
  • 1 location
Zanubrutinib in Patients With Waldenström's Macroglobulinemia (ARIADNE) (ARIADNE)

The objective of this non-interventional study (NIS) is to evaluate medical resource utilization, patient's quality of life (QoL), safety and effectiveness of zanubrutinib treatment in adult patients with Waldenström's macroglobulinemia in a real-world setting.

  • 0 views
  • 10 May, 2022
  • 1 location
Collection of Human Samples to Study Hairy Cell and Other Leukemias, and to Develop Recombinant Immunotoxins for Cancer Treatment

Background Researchers who are studying hairy cell leukemia, and how the disease compares with other disorders, are interested in obtaining additional samples from leukemia patients and healthy volunteers. The investigators are particularly interested in samples from individuals who have diseases that can be treated with a new type of drug …

Accepts healthy volunteers
leukemia
hematocrit
remission
cancer
  • 8 views
  • 27 Jun, 2022
  • 1 location
Ibrutinib Combined With R-CHOP/R-DHAP in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged ≤65 Years

The purpose of the study is to better and systematically collect clinical data on the treatment of ibrutinib combined with R-CHOP/DHAP regimen for more scientific and accurate evaluation, our center has carried out the R-CHOP/R-DHAP alternative regimen combined with ibrutinib at age ≤ An observational clinical study on the safety …

  • 0 views
  • 01 Jul, 2022
Ibrutinib Combined With Bendamustine and Rituximab in Newly Diagnosed Mantle Cell Lymphoma Patients Who Aged > 65 Years

This study is a prospective observational clinical trial. A total of 19 research centers were involved in this study. Each site plans to enroll 2-3 patients, and a total of 60 patients will be enrolled. Patients who met the diagnosis of mantle cell lymphoma by histological examination, ECOG (Eastern Oncology …

  • 0 views
  • 13 Jun, 2022
  • 1 location