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Found 49 clinical trials
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A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Brodalumab in Subjects With Inadequately Controlled Asthma and High Bronchodilator Reversibility.

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Brodalumab in Subjects With Inadequately Controlled Asthma and High Bronchodilator Reversibility.

  • 72 views
  • 23 Nov, 2020
  • 1 location
featured
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Lebrikizumab in Patients with Chronic Obstructive Pulmonary Disease and a History of Exacerbations

A Phase II, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of Lebrikizumab in Patients with Chronic Obstructive Pulmonary Disease and a History of Exacerbations

  • 242 views
  • 08 Nov, 2020
  • 1 location
A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control

of the standard nebulized dose of albuterol will be required to attain same bronchodilator response as a standard nebulizer treatment as determined by lung function measurement and that the

pulmonary function test
albuterol
bronchodilator
  • 74 views
  • 07 Nov, 2020
  • 1 location
Longitudinal 3He Magnetic Resonance Imaging of Healthy Lung

Healthy elderly subjects male and female aged 65-85 will undergo MRI, lung function and exercise testing for the development of tools to quantify and validate longitudinal in vivo magnetic resonance imaging phenotypes of the aging lung.

  • 2 views
  • 23 Jan, 2021
  • 1 location
Nebulised Liposomal Amphotericin for Invasive Pulmonary Aspergillosis (NAIFI01 Study)

The investigators aim to assess the safety and efficacy of nebulized liposomal amphotericin B (ALN) as a complementary therapy to the usual systemic treatment in patients with invasive pulmonary aspergillosis and the utility of a non-routine test as a surrogate marker of efficacy. To this end, a 3-year phase I, …

  • 6 views
  • 24 Jan, 2021
  • 1 location
Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial

Large population-based studies suggest that patients with chronic obstructive pulmonary disease (COPD) are 2 to 3 times at risk for cardiovascular mortality, which accounts for a large proportion of the total number of deaths. How COPD increases the risk of poor cardiovascular outcomes is largely unknown. However, there is growing …

corticosteroids
fluticasone
cigarette smoke
bronchodilator
  • 130 views
  • 07 Nov, 2020
  • 9 locations
RETHINC: REdefining THerapy In Early COPD for the Pulmonary Trials Cooperative

The study hypothesis is that symptomatic current and former smokers with spirometric values within the normal range (post-bronchodilator FEV1/FVC0.70 and post-BD FVC 70% predicted will still

bronchodilator therapy
glycopyrrolate
indacaterol
bronchodilator
  • 640 views
  • 24 Jan, 2021
  • 17 locations
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation

>Pre-bronchodilator forced expiratory volume in 1 second (FEV1) over 12 weeks compared to placebo Health related quality of life, assessed by the change from baseline to Week 52 in the St

muscarinic antagonists
bronchitis
pulmonary function test
dyspnea
severe chronic obstructive pulmonary disease
  • 1142 views
  • 17 Jan, 2021
  • 443 locations
Pivotal Study to Assess the Efficacy Safety and Tolerability of Dupilumab in Patients With Moderate to Severe COPD With Type 2 Inflammation

>Pre-bronchodilator forced expiratory volume in 1 second (FEV1) over 12 weeks compared to placebo Health related quality of life, assessed by the change from baseline to Week 52 in the St

muscarinic antagonists
bronchitis
pulmonary function test
dyspnea
severe chronic obstructive pulmonary disease
  • 156 views
  • 17 Jan, 2021
  • 173 locations
Fissure Closure With the AeriSeal System for CONVERTing Collateral Ventilation Status (CONVERT)

This is a prospective, open-label, multi-center, single-arm study to be conducted at up to 15 investigational sites. The Study plans to enroll 140 subjects with severe emphysema and collateral ventilation in the target lobe. This protocol is designed to evaluate the utility of the AeriSeal System to occlude collateral air …

  • 0 views
  • 18 Jan, 2021
  • 8 locations