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Found 76 clinical trials
Superinfection and Hyperinflammatory Phenotype in COVID-19 (Coronavirus Disease 2019) Pneumonia Patients (SUPER-HI)

Patients suffering from COVID-19 (Coronavirus Disease 2019) pneumonia are prone to bacterial and mycotic superinfection. According to existing evidence, the prevalence of superinfection is about 8% to 14% (95% CI 5-26%). However, the percentage of patients treated for superinfection is as high as 80%. There can be multiple reasons for …

  • 0 views
  • 10 Jul, 2022
  • 1 location
Early COPD for China Pulmonary Health Study Stage II

Discovery of the pathogenesis and targets in the progression of early chronic obstructive pulmonary disease

bronchodilator
COPD
  • 0 views
  • 06 Sep, 2021
  • 6 locations
Exhaled Breath Particles in Lung Transplantation

Lung transplantation (LTx) is the only effective treatment for patients with end stage lung disease. Of the major organs transplanted, survival following LTx is the lowest with a mean of 5 years. Despite improvements, primary graft dysfunction (PGD) remains the leading cause of early mortality and contributes to the development …

  • 0 views
  • 24 May, 2022
  • 1 location
Immune Interactions in Severe Asthma

This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time. Individuals are being asked to join a research study to help understand the differences in the …

bronchodilator
forced expiratory volume
methacholine
Accepts healthy volunteers
  • 25 views
  • 18 Apr, 2022
  • 1 location
Cytochrome P450 Epoxygenase Pathway Regulation of Macrophage Function

Background Respiratory diseases affect more than 1 billion people worldwide. They are a growing public health concern. The lungs are constantly exposed to environmental factors such as dust, fumes, microbes, and pollutants. But much is still not known about how these pollutants lead to respiratory illnesses. Researchers want to collect …

Accepts healthy volunteers
bronchoscopy
  • 0 views
  • 24 Oct, 2022
  • 1 location
Studying the Airway Microenvironment in Patients Undergoing Surgical and Bronchoscopic Interventions for COPD (COPD-ENVIRON)

Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

endobronchial cryotherapy
COPD
lung volume reduction
pulmonary disease
  • 63 views
  • 25 Feb, 2022
  • 1 location
Lung Macrophage Populations and Functions in Chronic Obstructive Pulmonary Disease (COPD)-Susceptible Smokers (Pre-COPD Pilot)

Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous disease that affects only a fraction of those who smoke tobacco. The origin of this variability in susceptibility to develop COPD is unclear, but understanding its underlying biology has important implications for our ability to design suitable preventative and therapeutic strategies for …

chronic obstructive pulmonary disease
tobacco smoke
Accepts healthy volunteers
COPD
  • 0 views
  • 19 Jun, 2022
  • 1 location
COPD Exacerbation Blood and Urine Biomarkers Study

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change …

pulmonary function test
chronic obstructive pulmonary disease
alpha 1-antitrypsin
COPD
copd exacerbation
  • 25 views
  • 22 Oct, 2022
Dysbiosis Impact on Lung Disease in HIV (DimPL)

Despite the high burden of respiratory symptoms in the HIV+ population, causes of chronic obstructive pulmonary disease (COPD) in individuals with HIV are poorly understood. Microbial communities present in the lungs or gut could play an important role in COPD via their ability to stimulate inflammation and oxidative stress and …

pulmonary function test
respiratory symptom
hiv-1 infection
drug use
HIV Vaccine
  • 0 views
  • 17 Feb, 2022
  • 1 location
The Italian REgistry of Pulmonary Non-tuberculous mycobactEria (IRENE)

The Italian registry of pulmonary non-tuberculous mycobacteria (NTM) -IRENE- is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory infection or NTM-Pulmonary Disease. The coordinating center is located at the Pulmonary Department of the Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy. So …

  • 6 views
  • 24 Feb, 2022
  • 1 location