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Found 79 clinical trials
A Single-cell Approach to Identify Biomarkers of Efficacy and Toxicity for ICI in NSCLC

of bronchoalveolar lavage (BAL) fluid from these ICI-treated cancer patients if they would develop ICI-pneumonitis. These mechanistic insights can directly lead to putative diagnostic biomarkers and

  • 0 views
  • 28 Mar, 2021
  • 1 location
Exhaled Breath Particles in Lung Cancer

lining fluid (RTLF) and that biomarkers found in EBP correlate to proteins that can be found in both bronchoalveolar lavage fluid (BALF) and plasma. Particle flow rate (PFR) has been found to differ

metastasis
lung cancer
cancer
lung carcinoma
  • 0 views
  • 03 Jun, 2022
  • 1 location
Exhaled Breath Particles as a Clinical Indicator for Lung Injury and Acute Respiratory Distress Syndrome (ARDS)

COVID19-induced ARDS. The investigators will also collect EBPs onto a membrane for subsequent molecular analysis. Previous studies have shown that most of those proteins found in bronchoalveolar lavage

ventilator-induced lung injury
respiratory distress
cytokines
lung injury
covid-19
  • 4 views
  • 22 Apr, 2022
  • 1 location
Host Response to Infection and Treatment in the Filarial Diseases of Humans

bronchoalveolar lavage. For this procedure, the mouth and throat are numbed with lidocaine jelly and spray and, if needed, a sedative is given for comfort. A small plastic tube is placed in a vein to give

swelling
blindness
ivermectin
sedative
diethylcarbamazine
  • 72 views
  • 22 Sep, 2022
  • 1 location
Natural History of Anthrax: A Study of Primary Infected, Recovered, and Exposed (SPoRE) Individuals and Evaluation of AVA Vaccinated Recipients

); b) lymph node biopsy. A sample of lymph node tissue is surgically removed under local anesthetic; c) bronchoalveolar lavage. This 15- to 30-minute procedure is done in the intensive

chest x-ray
diarrhea
anthrax vaccine adsorbed
lidocaine
antibiotic therapy
  • 13 views
  • 20 Sep, 2022
  • 1 location
Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons

Background COVID-19 virus infection differs among people. Some people have no or mild symptoms. For others, COVID-19 is life threatening and causes damage to the body s organs. Researchers want to better understand the virus to learn how to kill it. Objective To understand how the COVID-19 virus causes wide …

  • 0 views
  • 04 Oct, 2022
  • 2 locations
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Immunologic Features of Respiratory Failure in Pediatric Hematopoietic Cell Transplantation (HCT) Recipients and Pediatric Oncology Patients

This study is being done because researchers want to learn more about genes that control the immune response in the participant's lungs and blood when the participant have lung disease leading to respiratory failure. Primary Objective To evaluate the feasibility of performing single cell gene expression analyses on tracheal aspirates …

acute respiratory failure
assisted ventilation
pulmonary disease
mechanical ventilation
  • 0 views
  • 05 Apr, 2022
  • 1 location
In-depth Immunological Investigation of COVID-19. (COntAGIouS)

The COntAGIouS trial (COvid-19 Advanced Genetic and Immunologic Sampling; an in-depth characterization of the dynamic host immune response to coronavirus SARS-CoV-2) proposes a transdisciplinary approach to identify host factors resulting in hyper-susceptibility to SARS-CoV-2 infection, which is urgently needed for directed medical interventions.

coronavirus infection
covid-19
SARS
  • 20 views
  • 04 Oct, 2022
  • 1 location
Bronchoscopic Score for Prediction of Herpes Simplex-virus Type 1 (HSV-1) Reactivation

Tracheobronchial reactivation of HSV-1 is a common finding in critically ill patients and is associated with longer intensive care unit (ICU) stay and mechanical ventilation. At present it is unclear whether the presence of HSV-1 reactivation can be predicted by the clinical phenotype. In the present study, the performance of …

  • 0 views
  • 03 May, 2022
  • 1 location