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Found 58 clinical trials
Immune Interactions in Severe Asthma

This research study is being done to learn more about severe asthma by comparing people with severe asthma to those with milder forms of asthma and people without asthma, at baseline and over time. Individuals are being asked to join a research study to help understand the differences in the …

forced expiratory volume
Accepts healthy volunteers
  • 18 Apr, 2022
  • 1 location
COPD Exacerbation Blood and Urine Biomarkers Study

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change …

alpha 1-antitrypsin
chronic obstructive pulmonary disease
alpha1-proteinase inhibitor (human)
pulmonary function test
  • 22 Oct, 2022
Dysbiosis Impact on Lung Disease in HIV (DimPL)

Despite the high burden of respiratory symptoms in the HIV+ population, causes of chronic obstructive pulmonary disease (COPD) in individuals with HIV are poorly understood. Microbial communities present in the lungs or gut could play an important role in COPD via their ability to stimulate inflammation and oxidative stress and …

pulmonary function test
respiratory symptom
drug use
hiv-1 infection
HIV Vaccine
  • 17 Feb, 2022
  • 1 location
Pharmacological Evaluation of Antifungal in Chronic Pulmonary Aspergillosis (EPAR-APC)

At present, pulmonary diffusion and target antifungal concentrations for APC in patients with sarcoidosis or chronic obstructive pulmonary disease (COPD) are unknown.

  • 11 Jul, 2022
  • 1 location
Environmental Risk Factors for the Anti-synthetase Syndrome

Background Like other complex diseases, autoimmune diseases are the result of numerous causes, including genetic and environmental factors. Some researchers believe that people who are susceptible to autoimmune disorders develop them when the body reacts to environmental or other factors by creating white blood cells that attack the body s …

autoimmune disease
chest x-ray
pulmonary function test
pulmonary disease
  • 02 Sep, 2023
  • 2 locations
Non-invasive Diagnosis of Invasive Pulmonary Aspergillosis by Use of Biomarkers in Exhaled Breath Condensate (NIPA)

In this study, a new, non-invasive method for diagnosis of pulmonary aspergillosis (PA) will be tested in a clinical pilot project.

chest x-ray
mechanical ventilation
Accepts healthy volunteers
  • 22 Mar, 2022
  • 1 location
ILD-SARDs Registry and Biorepository

A complex interaction between demographic, environmental and genetic mechanisms impact the onset, severity and outcome of ILD-SARDs through dysregulation of the immune system and lung pro-biotic pathways. Comorbidity and genetic risk indicate that there are overlapping pathogenic mechanisms among SARDs, some of which underlie ILD in different SARDs. The purpose …

bronchoalveolar lavage
lung disease
connective tissue disease
chest ct
  • 18 Sep, 2021
  • 1 location
Chronic Cannabis Smoking, Oxidative Stress and the Pulmonary Innate Immune Response

This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.

  • 04 Oct, 2022
  • 1 location