Filter By
Clear all Advanced
I am/have/had
added new label for I am/have/had
more
I am looking for
added new label for I am looking for
more
Advanced Filters
Found 79 clinical trials
Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial (DART)

This is a a randomized double blind placebo controlled Phase 2 trial with a 12 patient lead-in to evaluate safety, prior to full enrollment to an additional 28 patients (for a total of 40 patients) to assess efficacy of decitabine in the treatment of critically ill patients with COVID-ARDS. The …

nasopharyngeal swab
pneumonia
PCR test
lung injury
FIO2
  • 69 views
  • 20 Jun, 2022
  • 1 location
Phase 1 Trial of ChAd68 and Ad5 Adenovirus COVID-19 Vaccines Delivered by Aerosol

This is a phase 1 study in healthy volunteers who have received two doses of an mRNA COVID-19 vaccine, to evaluate the safety and immune responses that develop in the blood and lungs following the administration by aerosol of either Ad5-triCoV/Mac or ChAd-triCoV/Mac, new experimental adenovirus-based vaccines expressing SARS-CoV-2 spike, …

Accepts healthy volunteers
  • 0 views
  • 30 Jun, 2022
  • 1 location
Obesity Metabolic Dysregulation and the Airway Epithelium in Asthmatics

The objective of this pilot study is to determine whether obesity and metabolic syndrome are in fact synergistic in relation to airway nitric oxide (NO) biology. To do so, the investigators want to determine how obesity and the metabolic syndrome relate to metabolism in bronchial airway epithelial cells and the …

cholesterol level
asthma
body mass index
a 12
pulmonary function test
  • 85 views
  • 30 Sep, 2021
  • 1 location
Metformin for Chemoprevention of Lung Cancer in High Risk Obese Individuals

This phase II trial determines the effect of metformin extended release on the risk for developing lung cancer in overweight/obese patients that are at high-risk for developing lung cancer. Metformin is widely used to treat type II diabetes and has a long history of safety and minimal side effects. At …

bronchoscopy
lung cancer
EGFR
lung carcinoma
diabetes
  • 0 views
  • 16 Sep, 2022
  • 2 locations
Effects of Tofacitinib vs Methotrexate on Rheumatoid Arthritis Interstitial Lung Disease (PULMORA)

Pulmonary abnormalities are present in up to 60% of patients with early rheumatoid arthritis (RA), and up to 10% of the patients will develop clinical interstitial lung disease (ILD). Recent data indicate that inhibition of Janus kinase is beneficial for this extra-articular manifestation. Our goal is to determine whether tofacitinib …

methotrexate
tofacitinib
prednisone
antirheumatics
interstitial lung disease
  • 1 views
  • 10 May, 2022
  • 1 location
Role of Lung Ultrasound and Pulsed-wave Doppler in Lung Consolidations in Mechanically Ventilated Patients

In infectious lung consolidations, the inhibition of hypoxic pulmonary vasoconstriction (HPV) results in a higher regional acceleration time (RAcT) compared to the RAcT measured in atelectatic consolidations.

chest x-ray
ct scan
x-rays
lung ultrasound
mechanical ventilation
  • 0 views
  • 12 Aug, 2022
  • 1 location
Infliximab and Intravenous Immunoglobulin Therapy in Treating Patients With Steroid-Refractory Pneumonitis

This phase II trial studies how well infliximab and intravenous immunoglobulin therapy work in treating patients with pneumonitis that does not respond to steroid treatment. Immunotherapy with monoclonal antibodies such as, infliximab, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow …

intravenous immunoglobulin
monoclonal antibodies
antibody therapy
antibiotics
corticosteroids
  • 0 views
  • 18 Nov, 2021
  • 5 locations
A Study to Determine Safety and Immunogenicity of the Candidate COVID-19 Vaccine AZD1222 Delivered by Aerosol in Healthy Adult Volunteers (COVAXAER01)

This study will test the COVID-19 vaccine candidate AZD1222 to investigate its safety, tolerability and capability of boosting immune responses both in the blood and the lung when administered to the respiratory tract, in volunteers previously vaccinated by intramuscular COVID-19 vaccination. Using standardised methods, we will measure immune responses in …

Accepts healthy volunteers
  • 0 views
  • 07 Apr, 2022
  • 1 location
Trial of Imatinib for Hospitalized Adults With COVID-19

This study is a randomized Double-Blind Placebo-Controlled Trial on the Safety and Efficacy of Imatinib for Hospitalized Adults with COVID-19

SARS
covid-19
oropharyngeal
  • 74 views
  • 27 Jul, 2022
  • 1 location
Diesel Exhaust Induces Glucocorticoid Resistance (DIGR)

The investigators are studying the effects of exposure to diesel exhaust on lung inflammation in the presence and absence of an inhaled corticosteroid. Although data is mixed, studies show that asthmatics have increased lung inflammation and worse symptoms during periods of higher air pollution despite taking their anti-inflammatory corticosteroid medication. …

  • 0 views
  • 01 Feb, 2022
  • 1 location