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Found 108 clinical trials
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High Flow Nasal Cannula in Pediatric Patients After Cardiothoracic Surgery

infants who suffer from bronchitis. However there is no evidence showing that HFNC can reduce "treatment failure" after extubation in pediatric patients after cardiothoracic surgery. This

  • 0 views
  • 26 Jan, 2021
  • 1 location
None
Roflumilast in Non-CF Bronchiectasis Study (2019)

to noxious environmental agents (e.g. tobacco smoke) that affects both the airways (chronic bronchitis) and lung parenchyma (emphysema), leading to loss of lung function and exercise capacity. Both

  • 0 views
  • 10 May, 2021
  • 1 location
None
Woodsmoke Particulate + Prednisone

Deployment of military personnel has been associated with increased respiratory illness likely due, in part, to inhalation of unusual particulate matter (PM), such as from burn pits. Inflammation is a key initial response to inhaled particulates. The researchers have developed a protocol using inhaled wood smoke particles (WSP) as a …

  • 0 views
  • 12 Sep, 2021
  • 1 location
None
Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children

We can not predict which wheezing child younger than 3 years of age benefits from systemic glucocorticoid and which one does not. It is not known whether the differences in the efficacy are related to the differences in viral etiology, atopy, immunogical maturity or age of the patient. The study …

atopy
prednisolone
  • 0 views
  • 07 Nov, 2020
  • 1 location
None
Assessment of Efficacy of KAN-JANG in Mild COVID-19

The complexity of COVID-19 suggests a potential need for a range of therapies, including antiviral agents, immunostimulants, immunosuppressants, adaptogens, and anticoagulants. In this context, implementation of polyvalency drugs, which exhibit a wide range of biological activities and multitarget effects that is common for herbal medicines and specifically for Kan Jang, …

  • 0 views
  • 01 Oct, 2021
  • 1 location
None
Pediatric Bronchiolitis Quality Improvement

Bronchiolitis is a respiratory illness characterized by acute inflammation of the airways, typically caused by a virus. By definition, it impacts children between 2 months and 2 years of age and is the most common cause of hospitalization among infants in the first year of life (American Academy of Pediatrics). …

treatment guidelines
antibacterial
acute bronchiolitis
bronchodilator
corticosteroids
  • 2 views
  • 26 Apr, 2021
  • 1 location
None
Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study

We hypothesize that infants with bronchiolitis treated with inhaled epinephrine in the Emergency Department (ED) and a 2-day course of oral dexamethasone will have fewer hospitalizations over 7 days compared to infants treated with placebo. To examine this hypothesis, we will conduct a phase III, multicentre, randomized, double-blind trial. Infants …

  • 7 views
  • 30 Apr, 2021
  • 12 locations
None
A Phase II Randomized Double-blind Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis

This is a research study to determine the efficacy and safety of investigational drug MEDI3506 for the treatment of adult subjects with Chronic Obstructive Pulmonary Disease and Chronic Bonchitis.

antibiotics
cough
pulmonary disease
body mass index
COPD
  • 38 views
  • 27 Oct, 2021
  • 112 locations
None
Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)

A multi-center, randomized, 36-month, parallel- group, non-inferiority, phase III study to compare the effectiveness of roflumilast (Daliresp, 500 mcg quaque die (QD) or alternate regimen) therapy versus azithromycin (250 mg QD, 500 mg QD three times per week, or alternate regimen) to prevent hospitalization or death in a patients at …

azithromycin
pulmonary disease
daliresp
COPD
muscarinic antagonist
  • 193 views
  • 30 Nov, 2021
  • 33 locations
None
Prospan Hustenz pfchen - Investigation on Efficacy and Tolerability in Children

The aims of this study are - Demonstrating superior efficacy of Prospan® Hustenzäpfchen compared to Placebo in children suffering from acute bronchitis accompanied by coughing

  • 50 views
  • 08 Nov, 2020
  • 1 location