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Found 108 clinical trials
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Multi Breath Nitrogen Washout (MBNW) as a Measure of Small Airway Function in Patients With Respiratory Disease

The researchers are investigating a novel technique, the multi breath nitrogen washout technique, to measure airway changes in various respiratory diseases.

lung transplant
respiratory disorder
cystic fibrosis
fibrosis
respiratory disease
  • 58 views
  • 07 Nov, 2020
  • 1 location
None
Measures of Respiratory Health (MRH)

The Lung Clearance Index, measured by multiple breath washout, is a measure of lung function that is considered a research tool in Canada as the device used to measure it is not approved by Health Canada. The study will assess lung function in patients undergoing routine lung function testing for …

respiratory disease
sweat test
pulmonary disease
cftr gene
respiratory disorder
  • 22 views
  • 23 Jan, 2021
  • 1 location
None
COPD Exacerbation Blood and Urine Biomarkers Study

This will be a prospective study examining serum levels of MMP-13 and alpha-1 antitrypsin as well as other biomarkers as well as urine biomarkers of smoking status and collagen degradation in the COPD patient population. Serum and urine biomarkers at baseline and after COPD exacerbations will be assessed against change …

copd exacerbation
alpha1-proteinase inhibitor (human)
chronic obstructive pulmonary disease
alpha 1-antitrypsin
pulmonary function test
  • 25 views
  • 05 Aug, 2021
None
Breath Condensate Study in Patients With Cystic Fibrosis.

There is an urgent need for a noninvasive method to diagnose bronchial infections and exacerbations in patients with Cystic Fibrosis (CF). The current method to diagnosed infections involves either collecting a sputum sample or obtaining a bronchoalveolar lavage (BAL). However, some patients cannot produce sputum. At the same time the …

Accepts healthy volunteers
fibrosis
  • 8 views
  • 06 Dec, 2021
  • 1 location
None
Pathogens Involved in Secondary Infections During Severe Forms of Covid-19 Pneumonia:

A Respiratory infection with the SARS-CoV2 virus is associated with a major risk of viral pneumonia that can lead to respiratory distress requiring resuscitation. In the most severe forms, it may require mechanical ventilation or even lead to an acute respiratory distress syndrome with a particularly poor prognosis. The SARS-CoV2 …

mechanical ventilation
covid-19
  • 0 views
  • 14 Aug, 2021
  • 1 location
None
Chronic Cannabis Smoking Oxidative Stress and the Pulmonary Innate Immune Response

This study plans to evaluate the effects of chronic cannabis smoking on lung health by evaluating its effects on pulmonary health, lung physiology and alveolar macrophage function.

venepuncture
  • 107 views
  • 28 Jun, 2021
  • 1 location
None
DNA Methylation Analysis in Acute Coronary Syndrome and Atrial Fibrillation: DIANA Clinical Trial

Although epigenetics has been identified as one of the most relevant pathophysiological components in the development of cardiovascular diseases, there is still considerable difficulty in finding markers of epigenetic damage useful in clinical practice. Moreover, these markers could be useful to predict the onset and severity of disease as well …

myocardial infarction
stemi
fibrillation
cardiovascular disease
angina pectoris
  • 0 views
  • 22 Mar, 2021
  • 1 location
None
Lum-Iva-biota: Exploring the Respiratory Mycobiota and Microbiota Profile in French CF Patients Taking Lumacaftor-Ivacaftor

n2015, VERTEX company - producing already KALYDECO (IVACAFTOR, VX-770) potentiator molecule that is recommended for the treatment of CF patients aged 6 y, with CFTR mutation altering the channel regulation (class III mutations) as G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549Nou S549R) -was allowed by the Federal Drug Administration …

lumacaftor
fibrosis
ivacaftor
vx-659
vx-770
  • 0 views
  • 24 Jan, 2021
  • 11 locations