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Found 88 clinical trials
Study of Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of QBW251 in Subjects With Bronchiectasis

The purpose of this study is to determine whether potentiating the cystic fibrosis transmembrane conductance regulator (CFTR) with QBW251 in patients with bronchiectasis will demonstrate

chest physiotherapy
macrolides
pulmonary function test
mucolytics
fibrosis
  • 6 views
  • 22 Apr, 2022
  • 14 locations
A Study to Test Whether Different Doses of BI 1291583 Help People With Bronchiectasis

This study is open to adults with bronchiectasis. People can join the study if they produce sputum and have a history of flare-ups (also called exacerbations). The purpose of this study

cough
antibiotics
ct scan
  • 0 views
  • 06 Jul, 2022
  • 22 locations
Efficacy and Safety of Benralizumab in Patients With Non-cystic Fibrosis Bronchiectasis (MAHALE)

placebo on top of standard-of-care therapy in adult patients with non-cystic fibrosis bronchiectasis with eosinophilic inflammation (NCFB+EI). All patients who complete the 52-week double-blind

  • 12 views
  • 19 Jun, 2022
  • 53 locations
A Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib in Participants With Non-Cystic Fibrosis Bronchiectasis (ASPEN)

The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.

  • 98 views
  • 03 Jul, 2022
  • 332 locations
Bacteriology and Inflammation in Bronchiectasis

Bronchiectasis is a chronic disease arises from progressive airway inflammation and infection. It has been postulated that bacterial infection triggers intense airway inflammation leading to

antibiotic therapy
bacterial infection
antibiotics
acute exacerbation of bronchiectasis
  • 43 views
  • 23 Jan, 2021
  • 1 location
Expiratory Muscle Training in Bronchiectasis

Reduced exercise tolerance is commonly reported in patients with bronchiectasis. The purpose of this study is to evaluate the effects of expiratory muscle training (EMT) and sham EMT (control

Accepts healthy volunteers
  • 0 views
  • 16 Jun, 2022
  • 1 location
Formoterol-beclomethasone in Patients With Bronchiectasis: a Randomized Controlled Trial (FORZA)

fibrosis (non-CF) bronchiectasis, native to inhaled corticosteroid (ICS) therapy and no history of asthma or chronic obstructive pulmonary disease (COPD)

macrolides
beclomethasone
high resolution computed tomography
fibrosis
asthma
  • 0 views
  • 10 Apr, 2022
  • 3 locations
Sputum Microbiota and the Association With Clinical Parameters in Steady-state Acute Exacerbation and Convalescence of Bronchiectasis

Study 1 is a cross-sectional investigation. Patients with clinically stable bronchiectasis (symptoms, including cough frequency, sputum volume and purulence, within normal daily variations) will

antibiotic therapy
spirometry
grip
antibiotics
cough
  • 29 views
  • 23 Jan, 2021
  • 1 location
Randomised Open Label Trial of Hypertonic Saline and Carbocisteine in Bronchiectasis (CLEAR) (CLEAR)

Patients with bronchiectasis (BE) suffer from a persistent cough, daily sputum expectoration, recurrent chest infections, and a poor health-related quality of life. Current guidelines for the

cough
antibiotics
high resolution computed tomography
chest infections
  • 0 views
  • 21 Mar, 2022
  • 12 locations
Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Health Benefits in Children With Bronchiectasis?

diseases including bronchiectasis, cystic fibrosis, and primary ciliary dyskinesia. Health insurance companies may cover these devices in some countries; but this is not a common practice around the world

cystic fibrosis
fibrosis
chest physiotherapy
  • 0 views
  • 19 Sep, 2021
  • 1 location