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Found 78 clinical trials
Specimen PET-CT Imaging for Intraoperative Margin Assessment in Breast Cancer (BrIMA)

Breast-conserving surgery (BCS) has become the standard-of-care for surgical management of the majority of women with early-stage breast cancer. Successful BCS entails excision of the tumor with

breast cancer staging
breast-conserving surgery
mammogram
early-stage breast cancer
  • 0 views
  • 04 Oct, 2022
  • 1 location
Monitoring Response to NAC and Prediction of pCR in Breast Cancer Patients Using Optical Imaging

Neoadjuvant chemotherapy (NAC) is the first line treatment for locally advanced breast cancer (BC). Besides making breast conserving surgery feasible, its main aim is to achieve a pathological

  • 0 views
  • 02 Mar, 2021
  • 1 location
Intraoperative Electron Radiotherapy for Low-risk Early Breast Cancer

Breast cancer is the most frequent malignancy in women. Standard therapy for early-stage breast cancer is breast conserving surgery (BCS) followed by adjuvant whole breast irradiation (WBI

endocrine therapy
estrogen
partial breast irradiation
estrogen receptor
breast cancer staging
  • 3 views
  • 29 Jun, 2021
  • 1 location
Single-dose Preoperative Partial Breast Irradiation in Low-risk Breast Cancer Patients (ABLATIVE-2)

In this ABLATIVE-2 trial, low-risk breast cancer patients will be treated with MRI-guided single dose preoperative partial breast radiotherapy to assess the rate of pathologic complete response after an interval of six to twelve months between radiotherapy and surgery. Response monitoring will be assessed using MRI and markers in blood …

  • 0 views
  • 14 Oct, 2022
  • 1 location
Effects of MK-3475 (Pembrolizumab) on the Breast Tumor Microenvironment in Triple Negative Breast Cancer With and Without Intra-operative RT: a Window of Opportunity Study (Pembro/IORT)

Assess response to pembrolizumab in both primary tumor, normal breast stroma, circulating lymphocytes and serum exosomes in treatment naive triple negative breast cancer (TNBC) patients. Assess for change in tumor-infiltrating lymphocytes (TILS) both stromal (sTILS) and intraepithelial (iTILS) in newly diagnosed early stage TNBC patients treated with two doses of …

triple negative breast cancer
pembrolizumab
carcinoma
mk-3475
HER2
  • 40 views
  • 28 Oct, 2022
  • 1 location
A Single Arm Phase 2 Study of Peri-Operative Ipilimumab, Nivolumab and Cryoablation in Women With Hormone Receptor-Negative, HER2-Negative Early Stage/Resectable Breast Cancer.

The purpose of this study is to determine the impact of pre-operative cryoablation, ipilimumab and nivolumab on on 3-year Event Free Survival (EFS), in women with residual hormone receptor negative, HER2-negative ("triple negative") resectable breast cancer after taxane-based neoadjuvant chemotherapy.

core needle biopsy
erbb2
breast adenocarcinoma
mammogram
carcinoma
  • 0 views
  • 28 Oct, 2022
  • 3 locations
NOVEMBER (Novem- (9), BrEast Radiation), A Phase II Trial of a 9 Day Course of Whole Breast Radiotherapy for Early Stage Breast Cancer (NOVEMBER)

This phase II trial studies how well hypofractionated radiation therapy works in treating patients with stage 0-IIB breast cancer. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells and have fewer side effects.

beta-human chorionic gonadotropin
lumpectomy
carcinoma
breast cancer
invasive carcinoma
  • 32 views
  • 23 Oct, 2022
  • 1 location
Effects of Active Release Technique (ART) on Pectoralis Minor Tightness in Post Mastectomy Women.

The aim of this research is to determine the Effects of Active Release Technique (ART) on pectoralis minor tightness in post mastectomy women. Randomized controlled trials will be done at Nuclear Medicine, Oncology and Radiotherapy Institute (NORI) Hospital. The sample size will be 60. The subjects were divided in two …

  • 0 views
  • 04 Oct, 2022
  • 1 location
Efficacy of IORT With CT-Guided HDR Brachytherapy for Treatment of Breast Cancer

The purpose of this study is to evaluate an investigational way to provide radiation therapy to treat early-stage breast cancer at the time of surgery.

breast cancer staging
breast-conserving surgery
early-stage breast cancer
  • 0 views
  • 23 Jan, 2021
  • 3 locations
Targeted Axillary Dissection (TAD) in Early-stage Node Positive Breast Cancer

RATIONALE: It is now standard for most breast cancer patients with 1-2 positive sentinel nodes to avoid completion node dissection when eligibility criteria from the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial are met. The National Comprehensive Cancer Network (NCCN) recently proposed to extend this indication to patients …

  • 0 views
  • 27 May, 2021
  • 2 locations