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Found 89 clinical trials
EXamining PErsonalised Radiation Therapy for Low-risk Early Breast Cancer

This is a randomised, phase III, non-inferiority trial evaluating radiation therapy versus observation following breast conserving surgery and planned endocrine therapy in patients with stage I

  • 685 views
  • 22 Apr, 2021
  • 47 locations
Adjuvant Whole Breast Radiotherapy (RT) With Intensity Modulated Radiotherapy (IMRT) and a Simultaneous Integrated Boost Versus Conventional RT and a Sequential Boost

consecutive boost in patients with breast cancer after breast conserving surgery. 502 patients will be recruited and randomized in two arms: patients in arm A will receive IMRT in 28 fractions delivering

immunostimulant
breast-conserving surgery
  • 0 views
  • 08 Nov, 2020
  • 1 location
Neoadjuvant Chemotherapy for Operable Premenopausal Breast Cancer Patients

therapy. Patients will undergo modified radical mastectomy or breast-conserving surgery after four cycles of neoadjuvant chemotherapy, and then receive postoperative chemotherapy (two cycles), radiation

  • 0 views
  • 21 Jan, 2021
  • 14 locations
A Comparison of Intra-operative Radiotherapy Boost With External Beam Radiotherapy Boost in Early Breast Cancer.

> Eligible patients are those with a higher risk of local recurrence after breast conserving surgery. After giving consent patients are randomised to either TARGIT Boost or EBRT Boost. All patients

  • 289 views
  • 22 Jan, 2021
  • 42 locations
Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years

This study will evaluate the effect of highly accelerated external beam radiotherapy (EBRT) in 5 fractions over 10 days compared to 15 fractions over 3 weeks for early as well as locally-advanced stage breast cancer. Primary endpoint will be chronic toxicity (breast deformation and retraction). Secondary endpoints are acute toxicity, …

  • 0 views
  • 23 Jan, 2021
Sequential Neo-adjuvant Chemotherapy Followed by Capecitabine Vs. Conventional Adjuvant Chemotherapy in Breast Cancer

This study evaluates whether sequential neo-adjuvant chemotherapy plus surgery followed by Capecitabine could achieve additional benefits over traditional postoperative chemotherapy. In the study group, patients that do not achieve pathological complete response(pCR) will receive sequential neo-adjuvant chemotherapy followed by Capecitabine. In the control group, patients will be treated with postoperative …

capecitabine
breast cancer
cancer
renal function
carcinoma
  • 0 views
  • 21 Jan, 2021
  • 1 location
Hypofractionated Radiotherapy After Breast Conserving Surgery

The optimal dose and fractionation regimen for whole breast irradiation, whole breast and regional nodal irradiation, and postmastectomy radiotherapy remains unknown. The goal of this phase II randomized controlled trial is to determine whether the hypofractionated proton regimens proposed are non-inferior compared with standard fractionated proton radiotherapy and therefore worthy …

adjuvant chemotherapy
breast-conserving surgery
  • 6 views
  • 08 Nov, 2020
  • 2 locations
Simulating Outcomes From Breast Conserving Surgery Using 3D Surface Imaging

Most women with breast cancer are able to have an operation to remove the cancer while preserving the breast (breast conserving therapy, BCT). Whilst cancer control is the most important goal, appearance of the breast after surgery has been shown to affect the quality of a woman's life after treatment. …

breast cancer
cancer
breast-conserving surgery
  • 0 views
  • 21 Jan, 2021
  • 1 location
Comparison of Acute Toxicity and Cost Between Whole Breast Irradiation With Sequential Boost and Simultaneous Integrated Boost After Breast Conserving Surgery.

Whole breast irradiation (WBI) after breast conserving surgery for early-stage breast cancer halves the recurrence risk and reduces the breast cancer death by about one sixth. A sequential

  • 3 views
  • 08 Nov, 2020
Breast Cancer Locator Guided vs. Wire Localized Partial Mastectomy for Breast Cancer

breast cancer or ductal carcinoma in situ (DCIS). Subjects will be randomized to breast conserving surgery (BCS) utilizing either the BCL or wire localization (WL) to guide surgery.

  • 0 views
  • 22 Jun, 2021
  • 14 locations