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Found 166 clinical trials
CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine EVErolimus or the Combination for Prevention of Recurrent Breast Cancer

To evaluate the feasibility of administering HCQ, EVE or the combination in patients who have completed primary therapy for breast cancer and harbor bone marrow disseminated tumor cells.

invasive breast cancer
triple-negative breast cancer
tumor cells
primary tumor
  • 25 Jan, 2021
  • 1 location
Clinical Significance of Supraclavicular Lymph Node Dissection for Breast Cancer Patients With Ipsilateral Supraclavicular Lymph Node Metastasis

Breast cancer patients with ipsilateral supraclavicular lymph node metastasis are defined as c stage (N3) according to the newly published 8th AJCC TNM staging system. No concret guide line was supported to such patients. It is still pending whether to exert supraclavicular lymph node dissection to breast cancer patients with …

  • 27 Apr, 2021
  • 1 location
Extended Cancer Education for Longer-Term Survivors in Primary Care for Patients With Stage I-II Breast or Prostate Cancer or Stage I-III Colorectal Cancer

This study tests four different methods of educating patients about follow-up care (NCI facing forward, brochure, EXCELS website alone, EXCELS health coaching alone and EXCELS website & health coaching combination) after cancer treatment ends. While it is known that patients need information to guide follow-up it remains unknown how to …

cancer diagnosis
cancer treatment
  • 25 Jan, 2021
  • 1 location
SAR408701 in Patients With CEACAM5-positive Advanced Solid Tumors

Primary Objective: -To assess the antitumor activity of SAR408701 in metastatic breast cancer (mBC) and metastatic pancreatic adenocarcinoma (mPAC) Secondary Objective: To assess the safety and tolerability of SAR408701 To assess other efficacy parameters of SAR408701 To assess the immunogenicity of SAR408701

  • 11 Apr, 2021
  • 9 locations
A Study of Pyrotinib in Combination With Trastuzumab and Docetaxel in Patients With HER2 Metastatic Breast Cancer

This is a randomized, double-blinded, multicenter phase 3 clinical trial to evaluate the efficacy and safety of pyrotinib plus trastuzumab plus docetaxel versus placebo plus trastuzumab plus docetaxel in patients who have HER2 positive metastatic breast cancer and have not received systemic anticancer therapy for advanced disease.

breast cancer
measurable disease
  • 25 Jan, 2021
  • 1 location
Pre Operative Trastuzumab in Operable Breast Cancer

Background Information and Rationale: Trastuzumab is a humanized monoclonal antibody that acts extracellularly on the erbB-2 receptor.Trastuzumab is a recombinant humanized IgG1 monoclonal antibody against the human epidermal growth factor receptor 2 (HER2/erbB-2),which has shown in both in vitro assays and in animals, to inhibit the proliferation of human tumour …

adjuvant chemotherapy
hormone therapy
monoclonal antibodies
  • 26 Jan, 2021
  • 1 location
Adjuvant Palbociclib in Elderly Patients With Breast Cancer

Phase II study to assess the efficacy of the combination of at least 5 year endocrine therapy and 2 year-palbociclib as adjuvant systemic treatment instead of adjuvant chemotherapy followed by endocrine therapy in older patients with stage II-III ER+/HER2- early breast cancer.

adjuvant chemotherapy
  • 28 Jan, 2021
  • 63 locations
Metastases-directed Radiotherapy in Addition to Standard Systemic Therapy in Patients With Oligometastatic Breast Cancer

The prognosis for patients with metastatic breast cancer has improved continuously. Systemic therapies alone are not able to cure the disease permanently. Investigators initiated this randomized controlled multinational and multicenter clinical trial to analyse the impact of a local metastases-directed radiotherapy in addition to standard systemic therapy in patients with …

  • 05 May, 2021
  • 14 locations
A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer

DESTINY-Breast 08 will investigate the safety, tolerability, PK and preliminary anti-tumour activity of T-DXd in combination with other therapies in patients with Metastatic HER2-low Advanced or Metastatic Breast Cancer

  • 25 Apr, 2021
  • 12 locations
Increasing Patients' Engagement in Breast Cancer Surgery Decision-Making

This trial studies how well a breast cancer surgery decision aid works in increasing patient engagement in decision making for patients with newly diagnosed stage 0-III breast cancer. The trial also examines barriers to patient engagement even with the use of a decision aid, and if barriers are more likely …

hearing impairment
breast surgery
  • 15 Mar, 2021
  • 62 locations