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Found 24 clinical trials
Testing the Drug Atezolizumab or Placebo With Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer

This randomized phase III trial studies how well paclitaxel, trastuzumab, and pertuzumab with or without atezolizumab works in treating patients with breast cancer that has spread to other parts of the body (metastatic). Drugs used in chemotherapy, such as paclitaxel, work in different ways to stop the growth of tumor …

tumor cells
staining intensity
estrogen receptor
pertuzumab
progesterone receptor
  • 438 views
  • 20 Jun, 2021
  • 459 locations
Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel With or Without Carboplatin in Treating Patients With Triple-Negative Breast Cancer

This randomized phase III trial studies how well doxorubicin hydrochloride and cyclophosphamide followed by paclitaxel with or without carboplatin work in treating patients with triple-negative breast cancer. Drugs used in chemotherapy, such as doxorubicin hydrochloride, cyclophosphamide, paclitaxel, and carboplatin, work in different ways to stop the growth of tumor cells, …

axillary lymph node dissection
immunohistochemistry
estrogen receptor
mastectomy
metastasis
  • 814 views
  • 24 Jan, 2021
  • 811 locations
Cicaderma Efficacy vs Standard Care of Sites in Preventing Radiodermatitis in Non-metastatic Breast Cancer Patients

Phase III, prospective, interventional, multicentric, comparative, randomized, open study with 2 parallel arms, evaluating the efficacy of Cicaderma ointment vs standard management of each site in preventing the onset of grade > 2 radiodermatitis according to the National Cancer Institute - Common Terminology Criteria for Adverse Events-Version (NCI-CTCAE-V5)

  • 0 views
  • 14 Feb, 2021
  • 3 locations
Partial Irradiation and Sequential vs. Concurrent Chemo Early Breast Cancer

In a small study at Johns Hopkins, women were treated with partial breast irradiation and chemotherapy given at the same time. We are now testing in a bigger study whether giving partial breast irradiation and chemotherapy at the same time (our new method) has the same side effects and outcomes …

hormone therapy
partial breast irradiation
cyclophosphamide
carboplatin
doxorubicin
  • 12 views
  • 25 Jan, 2021
  • 11 locations
Testing the Addition of Radium Therapy (Radium-223 Dichloride) to the Usual Chemotherapy Treatment (Paclitaxel) for Advanced Breast Cancer That Has Spread to the Bones

This phase II trial studies how well radium-223 dichloride and paclitaxel work in treating patients with advanced breast cancer that has spread to the bones. Radium-223 dichloride is a radioactive drug that behaves in a similar way to calcium and collects in cancer that has spread to the bones (bone …

  • 0 views
  • 20 Jun, 2021
  • 11 locations
Hypofractionated Regional Nodal Irradiation Clinical Trial for Women With Breast Cancer

Single-arm, phase 2 study evaluating hypofractionated irradiation of breast and regional nodes in women with breast cancer. Patients will be grouped in 3 surgery-related treatment groups: 1) An intact breast following lumpectomy; 2) plans for loco regional external beam radiotherapy (EBRT) following mastectomy (with or without plans for reconstruction); and …

axillary lymph node dissection
mastectomy
estrogen receptor
hysterectomy
breast tumor
  • 18 views
  • 24 Jan, 2021
  • 2 locations
An Oncolytic Measles Virus (MV-s-NAP) for the Treatment of Patients With Metastatic Breast Cancer

This phase I trial investigates the side effects and best dose of using a modified measles virus, MV-s-NAP, in treating patients with invasive breast cancer that has spread to other places in the body (metastatic). Both the unmodified vaccination measles virus (MV-Edm) and this modified virus (MV-s-NAP) have been shown …

pertuzumab
hormone therapy
epidermal growth factor receptor
progesterone receptor
metastasis
  • 0 views
  • 16 Jun, 2021
  • 1 location
Rebastinib Plus Antitubulin Therapy With Paclitaxel or Eribulin in Metastatic Breast Cancer

The purpose of this study is to determine the safety and tolerability of rebastinib when combined with antitubulin therapy with paclitaxel or eribulin in patients with advanced breast cancer.

hormone therapy
metastasis
erbb2
ejection fraction
docetaxel
  • 0 views
  • 27 Jan, 2021
  • 1 location
TPIV100 and Sargramostim for the Treatment of HER2 Positive Stage II-III Breast Cancer in Patients With Residual Disease After Chemotherapy and Surgery

This phase II trial studies how well TPIV100 and sargramostim work in treating patients with HER2 positive, stage II-III breast cancer that has remained after chemotherapy and surgery. It also studies why some HER2 positive breast cancer patients respond better to chemotherapy in combination with trastuzumab and pertuzumab. TPIV100 is …

sargramostim
her2 positive breast cancer
immunohistochemistry
estrogen receptor
tumor cells
  • 0 views
  • 18 Apr, 2021
  • 3 locations
Testing the Addition of an Anti-cancer Drug Berzosertib to the Usual Treatment (Radiation Therapy) for Chemotherapy-Resistant Triple-Negative and Estrogen and/or Progesterone Receptor Positive HER2 Negative Breast Cancer

This phase Ib trial studies the best dose of berzosertib when given together with the usual treatment (radiation therapy) in treating patients with triple negative or estrogen receptor and/or progesterone receptor positive, HER-2 negative breast cancer. Berzosertib may stop the growth of tumor cells by blocking some of the enzymes …

tumor cells
capecitabine
mastectomy
estrogen receptor
breast surgery
  • 0 views
  • 06 May, 2021
  • 5 locations