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Found 173 clinical trials
Efficacy of Clopidogrel on Incidence of Silent Brain Infarction (ECISBI)

Silent brain infarctions (SBIs) are a manifestation of covert cerebrovascular disease, without obvious clinical deficit, noted very often in patients presenting with a new stroke or new transient ischemic attack. SBIs are linked to a significant increase in risk for subsequent stroke and cognitive decline. However, no biomarker is currently …

  • 0 views
  • 22 Apr, 2022
  • 1 location
Delineating Between Pathophysiologic Phenotypes of Hypoxic Ischemic Brain Injury After Cardiac Arrest (DIFFUSION)

The main outcome determinant following cardiac arrest is hypoxic ischemic brain injury. Management has involved increasing the delivery of oxygen to the brain. This logic assumes that oxygen transport from blood into the brain is normal. We have demonstrated that this assumption is not true. A large proportion of post-cardiac …

  • 0 views
  • 03 Jun, 2022
  • 1 location
Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals

to high grade of WML on brain MRI.

hypertension
antihypertensive drugs
combinations
calcium
  • 0 views
  • 08 May, 2021
  • 2 locations
Ticagrelor Versus Clopidogrel in Carotid Artery Stenting (PRECISE-MRI)

aspirin and examined with brain MRI before and after stent treatment. The proportion of patients with new ischaemic lesions on MRI after treatment is compared between the two groups.

amaurosis fugax
stroke
atherosclerosis
MRI
ticagrelor
  • 97 views
  • 16 Mar, 2022
  • 14 locations
Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

safety of PCI or MRI surveillance is evaluated and analyzed. PCI is performed in hopes of preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI

  • 0 views
  • 10 May, 2021
  • 2 locations
SWOG S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

preventing spread of cancer into the brain. The use of brain MRI alone may reduce side effects of receiving PCI and prolong patients' lifespan. Monitoring with MRI scans alone (delaying radiation until the

hysterectomy
prophylactic cranial irradiation
heart failure
renal function test
antiretroviral therapy
  • 117 views
  • 27 Feb, 2022
  • 137 locations
Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis (DanNORMS)

The DanNORMS study is phase 3 non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.

ocrelizumab
myelopathies
methylprednisolone
disease or disorder
rituximab
  • 0 views
  • 11 May, 2022
  • 8 locations
A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease (Autonomy)

The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.

alzheimer's disease
dementia
cognitive decline
cognitive assessment
  • 57 views
  • 03 Jun, 2022
  • 112 locations
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)  

Primary Objective: To determine the efficacy of SAR442168 compared to placebo in delaying disability progression in primary progressive multiple sclerosis (PPMS) Secondary Objectives: To evaluate efficacy of SAR442168 compared to placebo on clinical endpoints, magnetic resonance imaging (MRI) lesions, cognitive performance, physical function, and quality of life To evaluate safety …

oligoclonal bands
disease or disorder
  • 108 views
  • 15 Jun, 2022
  • 49 locations
Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic …

  • 0 views
  • 25 Apr, 2022
  • 1 location