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Found 173 clinical trials
Polyneuropathy and COVID-19 (PolyneuroCOVID)

Since the onset of the Coronavirus pandemic disease 2019 (COVID-19), the Lombardy region and in particular the territory of the province of Brescia has been heavily affected. Current data show that the total number of confirmed cases in Italy of COVID-19 due to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) exceeds …

rehabilitation program
  • 22 Mar, 2022
  • 1 location
Stratification of Patient With Carotid Disease (TAXINOMISIS)

Introduction: Taxinomisis trial is part of the Taxinomisis project. The concept of the Taxinomisis project is to stratify carotid artery disease relying on new modern data corresponding to contemporary patients based on information from longitudinal studies. Taxinomisis trial will validate this tool and adjust such stratification. Initial step of the …

carotid disease
  • 05 Mar, 2022
  • 1 location
Blood Brain Barrier Dysfunction and Postoperative Neurocognitive Disorders

Postoperative neurocognitive disorders (PND), which include postoperative delirium and both acute and longlasting neurocognitive deficits, are a significant public health problem, leading to a cascade of deleterious complications. Older adults are particularly at-risk of developing PND both in the short and long term. Although age is consistently reported as an …

  • 06 Oct, 2021
  • 1 location
Neuropsychological Changes in Patients Receiving Radiation Therapy for Brain Metastases

Background There are no standardized sets of tests to measure changes in neuropsychological functioning in patients treated for brain metastasis (cancer that has spread beyond the original site to the brain). Neuropsychological function has an important effect on quality of life and should be included when determining treatment options. Objectives …

primary cancer
  • 19 Jun, 2022
  • 1 location
The GBA Multimodal Study in Parkinson's Disease

This study plans to analyze the molecular and clinical mechanisms of the relationship between the GBA mutations and Parkinson's disease. This will be assessed through the use of advanced neuroimaging techniques called PET (positron emission tomography) to study the accumulation of the tau protein and the dysfunction of acetylcholine and …

parkinson's disease
positron emission tomography
gba gene
  • 25 Jan, 2022
  • 3 locations
Accuracy and rEliabilitY of the vEstibuLo-ocular ExAmination Performed by inteRNs IN the emerGency Department (EYE LEARNING)

Dizziness, loss of balance, and unsteadiness of gait are common symptoms reported by Emergency Department (ED) patients. The incidence of acute vestibular syndrome (AVS) is increasing and reaches 2-4% of ED visits. In the ED of the Paris Saint Joseph Hospital Group, its incidence was 5% during the year 2019 …

  • 24 Mar, 2022
  • 1 location
The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study

Carotid artery disease is a main cause of ischemic stroke and vascular dementia, and a highly prevalent disease. There is uncertainty about the optimal management of patients with serendipitously or systematically detected asymptomatic carotid artery disease, due to the paucity of information on the predictive features of serious vascular events. …

  • 27 Jan, 2021
  • 1 location
Cerebrovascular Reserve and White Matter Disease in Patients With Chronic Anemia (CVR)

This is primarily an observational trial in patients with chronic anemia syndromes (sickle cell disease and thalassemia) and control subjects. The key purpose is to understand how brain blood flow reserve (the ability of the brain to increase its flow in response to stress) is altered in patients with chronic …

Accepts healthy volunteers
blood transfusion
transfusion dependent thalassemia
  • 15 Feb, 2022
  • 1 location
Study of Screening Brain MRIs in Stage IV Breast Cancer

The study is a single arm, nonrandomized phase II prospective study, with the goal of investigating the role of screening brain MRIs in neurologically asymptomatic patients with metastatic breast cancer.

stage iv breast cancer
  • 06 May, 2022
  • 1 location
Central Vein Sign: a Diagnostic Biomarker in Multiple Sclerosis (CAVS-MS)

The need for improved diagnostic methods in Multiple Sclerosis (MS) is widely recognized. Although Magnetic Resonance Imaging (MRI) is a longstanding tool for detecting MS lesions, diagnostic inaccuracies persist. Up to 20% of people diagnosed with MS (1 in 5) are later found not to have the disease. This is …

disease or disorder
optic neuritis
  • 22 Apr, 2022
  • 11 locations