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Found 361 clinical trials
Chemo-immunotherapy Plus Thoracic Radiotherapy in Extensive Stage Small-cell Lung Cancer (TRIPLEX)

Studies have shown that combining chemotherapy and immune checkpoint inhibitors (ICI) prolongs survival compared with chemotherapy alone in extensive stage small-cell lung cancer (ES SCLC), but the survival benefit is modest. The main aim of this trial is to investigate whether there is a synergistic/additive effect of concurrent thoracic radiotherapy …

carboplatin
brain metastases
cancer chemotherapy
etoposide
progressive disease
  • 0 views
  • 25 Mar, 2022
  • 16 locations
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer (DB-07)

DESTINY-Breast07 will investigate the safety, tolerability, and anti-tumour activity of trastuzumab deruxtecan (T-DXd) in combination with other anti-cancer agents in patients with HER2-positive Metastatic Breast Cancer

  • 0 views
  • 15 Jun, 2022
  • 57 locations
SWOG S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer

This phase III trial studies magnetic resonance imaging (MRI) surveillance and prophylactic cranial irradiation (PCI) to see how well they work compared to MRI surveillance alone in treating patients with small cell lung cancer. MRI scans are used to monitor the possible spread of the cancer with an MRI machine …

tubal ligation
cancer
platinum-based chemotherapy
metastasis
HIV Infection
  • 117 views
  • 27 Feb, 2022
  • 137 locations
Palbociclib In Progressive Brain Metastases

This research study is studying palbociclib as a possible treatment for recurrent brain metastases. Pfizer, a pharmaceutical company, is supporting this research study by providing

  • 84 views
  • 27 Jan, 2022
  • 1 location
Stereotactic Radiosurgery (SRS) for Brain Metastasis (SRS)

SRS dose escalation for brain metastases in radiation-naïve patients will establish true tolerable doses, which may exceed the current standard doses. This may lead to an improvement in local

  • 3 views
  • 22 Mar, 2022
  • 1 location
Frameless Stereotactic Radiosurgery for Intact Brain Metastases

This is a randomized study to determine if not treating planning target volume (PTV) margins during radiation therapy worsens progression free survival rates in patients with brain metastases

metastasis
cancer
measurable disease
stereotactic radiosurgery
  • 39 views
  • 23 Feb, 2022
  • 1 location
NovoTTF-200A + Pembrolizumab In Melanoma Brain Metastasis

the study device, NovoTTF-200A, in melanoma participants with brain metastases when it is combined with Pembrolizumab. The name of the study device involved in this study is: -- NovoTTF

  • 0 views
  • 26 Jan, 2021
Preoperative Stereotactic Radiosurgery for Brain Metastases (STEP)

STEP is a French multicentre, prospective, non-randomized, phase II study designed to assess 6-months local control after pre-operative stereotactic radiosurgery (SRS) for patients with brain

  • 0 views
  • 25 Apr, 2022
  • 7 locations
IORT After Surgical Resection of Brain Metastases

To evaluate the feasibility and efficacy of the Intraoperative Radiation Therapy (IORT) after the resection of a brain metastases to reduce the incidence of local relapse

Accepts healthy volunteers
  • 0 views
  • 25 Oct, 2021
  • 1 location
Preop fSRS for Resectable Brain Metastases

The purpose of the study is to determine whether treatment with pre-operative hypofractionated stereotactic radiosurgery followed by surgery will improve time to local failure (TTLF) compared to the current standard of care.

  • 0 views
  • 15 Mar, 2022
  • 1 location