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Found 362 clinical trials
A Phase II Randomized Study Evaluating Molecular Profiling and Targeted Therapy in Patients With Metastatic Cancer

This randomized clinical trial studies how molecular profiling and targeted therapy work in treating patients with cancer that has spread to other places in the body compared to standard treatment. Information about genetic differences in a patient's tumor can be used to choose treatment that may target the tumor. It …

carcinoma
brain metastases
cancer
liver metastasis
neutrophil count
  • 20 views
  • 25 May, 2022
  • 1 location
A Study of V937 in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Solid Tumors (V937-013)

The purpose of this study is to evaluate the safety, tolerability, and efficacy in participants with advanced/metastatic or recurrent malignancies who receive V937 in Combination with Pembrolizumab (MK-3475). The primary objective for Part 1 is to evaluate the objective response rate, and the primary objective for Part 2 is to …

HER2
epidermal growth factor receptor
growth factor
x-rays
EGFR
  • 0 views
  • 17 Jun, 2022
  • 26 locations
  • 0 views
  • 17 Feb, 2022
  • 1 location
Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy

and prolong patients' lifespan. MRI surveillance alone (delaying radiation until the actual brain metastasis) may be not inferior to PCI.

  • 0 views
  • 10 May, 2021
  • 2 locations
Measurement and Characterization of Circulating Endothelial Cells or Circulating Tumor Cells or Circulating DNA in Adult Patients With Metastatic Cancer

Monitoring of circulating endothelial cells (CEC and mature cells called progenitors called CEP) or circulating tumor cells (CTC) in adult patients with metastatic cancer, possibly treated with targeted therapy.

tumor cells
targeted therapy
cancer
metastasis
solid tumor
  • 7 views
  • 21 Jan, 2021
  • 1 location
CPCT-02 Biopsy Protocol

A major challenge for researchers in cancer care is to expedite the development of new therapeutics and the Center for Personalized Cancer Treatment (a collaboration of the Dept. of Medical Oncology from the University Medical Center Utrecht, Netherlands Cancer Center - Antoni van Leeuwenhoek hospital and the Erasmus Medical Center …

targeted therapy
cancer
solid neoplasm
metastatic pancreatic cancer
leucovorin
  • 8 views
  • 25 Jan, 2021
  • 2 locations
IMMUNOtherapy and Stereotactic ABlative Radiotherapy (IMMUNOSABR) a Phase II Study (IMMUNOSABR2)

This will be a phase II trial testing if the combination of stereotactic ablative body radiotherapy (SABR) and L19-IL2 improve the progression-free survival in patients with limited metastatic non-small cell lung cancer (NSCLC). The trial consists of one cohort with two arms; C-arm and an E-arm. Patients with oligometastatic disease …

monoclonal antibodies
stereotactic body radiation therapy
lung cancer
neutrophil count
liver metastasis
  • 2 views
  • 03 Mar, 2022
  • 10 locations
A Study to Examine the Value of Broad Agnostic Next Generation Sequencing (NGS) Panel Testing Versus Reimbursed Organ-directed NGS: a Belgian Precision Study of the BSMO in Collaboration With the Cancer Center

Title of the study A study to examine the value of broad agnostic NGS panel testing versus reimbursed organ-directed NGS: a Belgian Precision study of the BSMO in collaboration with the Cancer Centre Study Number BSMO 2020-1 Study Phase Exploratory Sponsor Belgian Society of medical Oncology (BSMO) Treatment None Background …

breast cancer
EGFR
cancer
  • 0 views
  • 05 Jun, 2021
  • 12 locations
Safety and Efficacy Study of SAR442720 in Combination With Other Agents in Advanced Malignancies

Primary Objectives: Part 1 To characterize the safety and tolerability of SAR442720 in combination with pembrolizumab in participants with advanced solid tumors. To define the MTD and RP2D for the combination of SAR442720 and pembrolizumab in participants with solid tumors. Part 2 To determine the anti-tumor activity of SAR442720 in …

pembrolizumab
cancer
solid neoplasm
BRAF
measurable disease
  • 68 views
  • 24 May, 2022
  • 18 locations
A First-in-Human Dose Escalation and Expansion Study to Evaluate Intratumoral Administration of SAR441000 as Monotherapy and in Combination With Cemiplimab in Patients With Advanced Solid Tumors

Primary Objectives: Dose Escalation: To determine maximum tolerated dose (MTD) or maximum administered dose (MAD) and overall safety and tolerability profile of SAR441000 when administered intratumorally as monotherapy and in combination with cemiplimab in patients who have no alternative standard treatment options. Dose Expansion (Combination): To determine the objective response …

squamous cell carcinoma of head and neck
lymphoma
carcinoma
cancer
solid neoplasm
  • 62 views
  • 27 May, 2022
  • 18 locations