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Found 228 clinical trials
Investigating Gains in Neurocognition in an Intervention Trial of Exercise

This randomized control trial will examine whether a 12 month monitored exercise intervention improves brain health in cognitively normal older adults. This trial will also address several important unanswered questions: (1) Are the recommended public health guidelines of 150 minutes/week of exercise sufficient for improving cognitive performance? (2) Does exercise …

  • 30 views
  • 04 Mar, 2021
  • 4 locations
Bridging the Childhood Epilepsy Treatment Gap in Africa

About half of the world's children with epilepsy do not receive treatment - known as the epilepsy treatment gap - with significantly higher rates (67%-90%) in low- and middle-income countries (LMICs). We will conduct the first cluster-randomized clinical trial (cRCT) to determine the efficacy, implementation, and cost-effectiveness of a novel …

seizure
  • 0 views
  • 29 Mar, 2021
  • 3 locations
PREvention of STroke in Intracerebral haemorrhaGE Survivors With Atrial Fibrillation

Atrial fibrillation (AF) is the most common form of irregular heart rhythm. In people with AF, blood clots often form in the heart, which can travel to the brain. Blockage of brain arteries by these clots is a major cause of stroke. This type of stroke is called an ischaemic …

clot
apixaban oral tablet
brain imaging
vascular disease
edoxaban
  • 13 views
  • 25 Feb, 2021
  • 28 locations
Treatment of Brain AVMs (TOBAS) Study

The objectives of this study and registry are to offer the best management possible for patients with brain arteriovenous malformations (AVMs) (ruptured or unruptured) in terms of long-term outcomes, despite the presence of uncertainty. Management may include interventional therapy (with endovascular procedures, neurosurgery, or radiotherapy, alone or in combination) or …

brain disorders
endovascular procedures
endovascular procedure
stroke
infarction
  • 407 views
  • 04 Aug, 2021
  • 33 locations
The Swedish BioFINDER 2 Study

The Swedish BioFINDER 2 study is a new study that will launch in 2017 and extends the previous cohorts of BioFINDER 1 study (www.biofinder.se). BioFINDER 1 is used e.g. to characterize the role of beta-amyloid pathology in early diagnosis of Alzheimer's disease (AD) using amyloid-PET (18F-Flutemetamol) and A analysis in …

neurodegenerative diseases
cognitive symptoms
tauopathies
flutemetamol
alzheimer's disease
  • 165 views
  • 11 Mar, 2021
  • 3 locations
Brain Imaging Study on Biomarkers for Fibromyalgia

Drugs used for managing Fibromyalgia pain have not proven to be effective and pain continues to cost Canadians $60 billion a year without truly helping those who suffer. The study proposes to investigate the factors related to a person that can enhance or reduce the effectiveness of pain treatments in …

chronic pain
analgesics
sham treatment
  • 169 views
  • 24 Jan, 2021
  • 1 location
Mitochondrial Stress Brain Imaging and Epigenetics

The MiSBIE study collects biological, behavioral, psychosocial, neuropsychological, and brain imaging data in participants with either: normal mitochondrial function, individuals with the m

  • 0 views
  • 14 Apr, 2021
  • 1 location
Defining Adolescent Nausea Through Brain Imaging and Neurostimulation Response

This study evaluates the efficacy of auricular neurostimulation via an non-invasive percutaneous electrical nerve field stimulator (PENFS) in adolescents with functional nausea. A neurostimulator is applied to the outer ear and stimulates several nerves that are thought to be involved in transmission of nausea and vomiting signals. Half of the …

nausea
nausea and vomiting
vomiting
  • 9 views
  • 29 Jan, 2021
  • 1 location
Brain Imaging in Tobacco Smokers During a Quit Attempt

The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in 7 nicotinic acetylcholine receptor (nAChR) availability when compared to matched historical controls using positron emission tomography (PET) imaging and the radioactive ligand [18F]-ASEM (3-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-6 [18F]fluorodibenzo[b,d]thiophene 5,5-dioxide), an 7 nAChR antagonist. The …

carbon monoxide
nicotine product
pet imaging
brain imaging
cotinine
  • 19 views
  • 17 Jun, 2021
  • 1 location
Neuromodulation in the Elderly Depressed: a Brain Imaging Pilot Study

To evaluate safety and efficacy of an accelerated deep brain Transcranial Magnetic stimulation (adTMS) and transcutaneous direct current stimulation (tDCS) protocol in an elderly depressed patient population

  • 0 views
  • 08 May, 2021
  • 1 location