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Found 229 clinical trials
Phenylbutyrate for STXBP1 Encephalopathy

STXBP1 Encephalopathy is a severe disease that can cause seizures and developmental delays in infants and children. It occurs when one copy of the STXBP1 gene has a mutation that causes the gene's protein to not work properly. It is possible that a medication called phenylbutyrate may help the protein …

  • 0 views
  • 01 Jul, 2021
  • 1 location
Perturbation Training to Improve Balance Recovery of Old Adults

Falls are major contributors for immobility and independency. Most falls in older adults occur during walking after a sudden unexpected loss of balance. It was well-established that balance can be improved by performance of a training program that provides perturbation (unexpected perturbations of balance). The main aim of the current …

  • 0 views
  • 27 Jan, 2021
  • 3 locations
Stereotactic Radiosurgery to the Resection Cavity Following Surgical Removal of Brain Metastasis

Brain metastases (BM) are the most common intracranial tumors in adults and source of the most common neurological complications of systemic cancer. Surgery and radiation therapy are the most important components in the management of BM with the goal to prolong survival and improve the quality of life. Whole brain …

brain metastases
cancer
metastasis
karnofsky performance status
stereotactic radiosurgery
  • 12 views
  • 07 Nov, 2020
  • 1 location
Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action

The purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs …

antidepressants
emgality 120 mg in 1 ml prefilled syringe
migraine
headache
galcanezumab
  • 0 views
  • 24 Jan, 2021
  • 1 location
Priming With tDCS: Expanding the Window of Recovery in Chronic Stroke

Stroke often leads to long-term disability including upper extremity (UE) dysfunction even with the provision of timely rehabilitation services. Brain injury stemming from stroke, affecting the corticospinal system results in weakness, alterations in muscle tone and incoordination during the performance of functional tasks. Recovery of functional task performance after injury …

  • 1 views
  • 11 May, 2021
  • 1 location
Transcranial Magnetic Stimulation (TMS) in Schizophrenia

Until recently stimulation of nervous tissue deeper than approximately 2 cm from the scalp (will hence be called non-deep TMS) was not possible (3).A new coil ("H"-coil invented in Weizmann Institute of Science, Neurobiology Department, Rehovot, Israel ) capable of stimulating more than twice this depth (Up to 5 cm)was …

auditory hallucinations
hallucinations
psychotropic drugs
suicide
  • 8 views
  • 07 Nov, 2020
  • 1 location
Clinical Utility of Automated Electric Source Imaging in Presurgical Evaluation

Electrical source imaging is part of the presurgical evaluation of patients with drug-resistant focal epilepsy. The software packages that will be used in this study have Declaration of Conformity within the European Economic Area (CE mark) for this specific medical use. In spite of being part of the clinical standard, …

epilepsy monitoring
electroencephalogram
epilepsy surgery
seizure
epilepsy
  • 3 views
  • 03 Feb, 2021
  • 13 locations
Brain Changes in Fear

The purpose of this study is to use brain imaging technology to investigate brain changes in people exposed to predictable versus unpredictable unpleasant stimuli. Unpleasant events that can be

anxiety
depressive disorder
specific phobia
depression
traumatic stress disorder
  • 504 views
  • 28 Jul, 2021
  • 1 location
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

effects of addiction on the brain. Objectives To develop new functional and structural MRI techniques, and to evaluate their potential use in brain

drug dependence
drug use
addiction
breathalyzer test
carbon monoxide
  • 488 views
  • 29 Jul, 2021
  • 1 location
A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

This trial will enroll patients that have been diagnosed with a transient ischemic attack (TIA) or minor stroke that has occurred within the past 12 hours. Anyone diagnosed with a minor stroke faces the possibility of long-term disability and even death, regardless of treatment. Stroke symptoms such as weakness, difficulty …

deficit
angiography
computed tomography perfusion
ischemia
weakness
  • 96 views
  • 26 Jan, 2021
  • 59 locations