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Found 229 clinical trials
Dopamine Receptor Contributions to Prediction Error and Reversal Learning in Anorexia Nervosa

food restriction could have implications for the pathophysiology of AN. Dopamine-related brain function has been studied indirectly using functional magnetic resonance brain imaging (fMRI) and tasks

  • 0 views
  • 26 Jan, 2021
  • 1 location
Treatment Youth With Obsessive-Compulsive Disorder

investigate how 40 youth with OCD (recruited in specialized clinics) differ from 40 healthy youth (recruited from the local community) on selected cognitive tests and brain imaging paradigms, as

anxiety
citalopram
psychotropic drugs
  • 134 views
  • 07 Nov, 2020
  • 1 location
Developing an EEG Paradigm to Study Prediction Error in Anorexia Nervosa

treatment outcome. However, functional brain imaging is costly, prohibitive for instance for individuals with braces or other metal in their body and only available at certain centers. In order to study PE

  • 0 views
  • 25 Feb, 2021
  • 1 location
rAAV-Olig001-ASPA Gene Therapy for Treatment of Children With Typical Canavan Disease

therapy to affected regions of the brain. Outcome measures for the open label clinical trial include longitudinal clinical assessments and brain imaging. Currently there is no effective treatment

  • 0 views
  • 14 Apr, 2021
  • 1 location
Hydroxyurea Therapy for Neurological and Cognitive Protection in Pediatric Sickle Cell Anemia in Uganda ( BRAINSAFE-II )

randomly selected subset of 90 participants, an evaluation of the impact of hydroxyurea on structural brain vascular injury using magnetic resonance brain imaging (MRI) and magnetic vessel imaging ,also

  • 0 views
  • 06 Apr, 2021
  • 1 location
Multidisciplinary Translational Approach to Investigate Mechanisms Predictors & Prevention of Persistent PTH

This is a United States Department of Defense funded Focused Program study that aims to identify mechanisms and predictors for persistent of post-traumatic headache attributed to mild traumatic brain injury, and identify methods of preventing post-traumatic headache persistence. The objective of the clinical trial component of the Focused Program is …

  • 0 views
  • 18 Feb, 2021
  • 3 locations
Neuroprotective Effects of Risperdal on Brain and Cognition in 22q11 Deletion Syndrome

Chromosome 22q11.2 deletion syndrome (22q11DS) is a neurogenetic condition associated with a high risk of psychiatric disorders, including schizophrenia spectrum disorders. This population is characterized by a particular neurocognitive profile and atypical brain development. Risperidone is a second-generation antipsychotic, inhibitor of dopaminergic receptors. Used in the treatment of psychosis, risperidone …

  • 0 views
  • 26 Jan, 2021
  • 1 location
An Investigation of Brain Tumor Metabolism in Patients Undergoing Surgical Resection

The study is designed to use infusion of a non-radioactive, naturally occurring isotope of glucose (13C) in patients undergoing surgical resection for a newly identified brain mass to obtain the metabolic phenotype of the tumor, and correlate it with the histopathological diagnosis. In each patient, 13C NMR spectral analysis of …

  • 4 views
  • 11 Apr, 2021
  • 1 location
EEG Brain Activity At Various Cycling Intensities

The aim of this study is to investigate brain activity with EEG during incremental cycling at various cycling intensities.

  • 0 views
  • 30 Apr, 2021
  • 1 location
Target Engagement of Terazosin in Healthy Adults

The purpose of the study is to assess the target engagement of Terazosin (TZ) in a single cohort of 6 healthy adult participants. During the study participants will undergo PET/CT scans, 7-Tesla MRI scans, blood draws, and an optional lumbar puncture (LP.)

  • 0 views
  • 11 Apr, 2021
  • 1 location