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Found 5 clinical trials
Anlotinib to Malignant Brainstem Glioma

This study is a single-arm, open-label, phase II study of anlotinib combined with radiation in the treatment of patients with malignant brainstem glioma. Twenty five patients will be enrolled in the study who is diagonsis with malignant brainstem glioma. The primary objective includes disease control rate (DCR), the role of …

  • 26 Jan, 2021
  • 1 location
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

expected to be fast growing and aggressive), diffuse intrinsic pontine gliomas (brain stem tumors), brain tumors with a high number of genetic mutations, ependymoma or medulloblastoma that have come back

primary brain tumors
monoclonal antibodies
glomerular filtration rate
  • 02 Jan, 2022
  • 11 locations
Phase I Study of Mebendazole Therapy for Recurrent/Progressive Pediatric Brain Tumors

This is a safety (Phase 1) trial using mebendazole for recurrent pediatric brain cancers that include medulloblastoma and high grade glioma, that are no longing responding to standard therapies. The drug mebendazole is an oral drug in a chewable 500 mg orange flavored tablet. It is already approved to treat …

neutrophil count
malignant glioma
malignant brain tumor
  • 30 Sep, 2021
  • 2 locations
Adjuvant Dendritic Cell Immunotherapy for Pediatric Patients With High-grade Glioma or Diffuse Intrinsic Pontine Glioma

immunity. A clinical study including 10 pediatric patients (aged 12 months and < 18 years at the time of signing the informed consent) with brain (stem) tumors is initiated at the Antwerp

  • 28 Sep, 2021
  • 1 location
The Registry of Oncology Outcomes Associated With Testing and Treatment

This study is to collect and validate regulatory-grade real-world data (RWD) in oncology using the novel, Master Observational Trial construct. This data can be then used in real-world evidence (RWE) generation. It will also create reusable infrastructure to allow creation or affiliation with many additional RWD/RWE efforts both prospective and …

diagnostic procedures
lab tests
primary cancer
  • 22 Oct, 2021
  • 1 location