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Found 47 clinical trials
Longitudinal Neuroimaging in Sturge-Weber Syndrome

brain disorders in the future. The investigators will also study how advanced MRI, including susceptibility-weighted and diffusion tensor imaging can detect detailed signs of brain vascular and neuronal

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will undergo PET scans of the brain at two weeks and two months after injury to measure neuro-inflammation. The results of …

  • 5 views
  • 04 Oct, 2022
  • 1 location
An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE (EPIK-OLE)

To assess the long-term safety and tolerability of XEN496 in pediatric subjects with KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE) who had participated in the primary study (XPF-009-301).

ezogabine
  • 0 views
  • 07 Oct, 2022
  • 12 locations
XEN496 (Ezogabine) in Children With KCNQ2 Developmental and Epileptic Encephalopathy (EPIK)

To investigate the potential antiseizure effects of adjunctive XEN496 (ezogabine) compared with placebo in children with KCNQ2 Developmental and Epileptic Encephalopathy (KCNQ2-DEE).

stroke
electroencephalogram
seizure
ketogenic diet
ezogabine
  • 8 views
  • 04 Oct, 2022
  • 16 locations
A Study of Different Donanemab (LY3002813) Dosing Regimens in Adults With Early Alzheimer's Disease (TRAILBLAZER-ALZ 6)

This study will investigate different donanemab dosing regimens and their effect on the frequency and severity of ARIA-E in adults with early symptomatic Alzheimer's disease (AD) and explore participant characteristics that might predict risk of ARIA.

  • 0 views
  • 06 Apr, 2023
  • 31 locations
A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)

The reason for this study is to assess the safety and efficacy of donanemab in participants with early Alzheimer's disease. The study duration including screening and follow-up is up to 93 weeks.

  • 0 views
  • 04 May, 2023
  • 40 locations
The SINgapore GERiatric Intervention Study to Reduce Cognitive Decline and Physical Frailty (SINGER) Study (SINGER)

A study in Finland found that a multidomain intervention of physical activity, nutritional guidance, cognitive training, social activities and management of vascular risk factors slowed cognitive decline in healthy older adults at increased risk of cognitive decline. A 6-month pilot study was initiated in Singapore, which demonstrated the cultural feasibility …

dementia
cognitive decline
Accepts healthy volunteers
  • 0 views
  • 24 Jan, 2022
  • 2 locations
Creation of a Probabilistic Atlas of Normal Cerebral Uptake of 18F-FDG in PET/MRI. (ATLATEP)

With 18F-FDG PET, we have few atlases of normality allowing the realization of objective quantitative analyses. An atlas of normality is a probabilistic atlas of normal FDG uptake from a representative set of brain PET images of healthy subjects. This type of atlas is essential for intra- and inter-individual comparisons. …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Upper Limb Rehabilitation Using Virtual Reality in Children With Cerebral Palsy (RV-REEDUC) (RV-REEDUC)

This study aims to evaluate the effect of a virtual reality rehabilitation protocol on visuo-motor coordination and upper limb functional abilities in children with unilateral or bilateral cerebral palsy.

hemiplegia
rehabilitation therapy
range of motion
quadriplegia
  • 0 views
  • 27 May, 2022
  • 2 locations
Metabolic and Hemodynamic Reserve in Pediatric SCA

The purpose of this research study is to better understand how blood flow and metabolism change can influence brain development in the early decades of life. SCA participants and healthy controls are age and sex-matched for comparison. Within the SCA cohort, children with infarcts may have thinner cortices than those …

stroke
Accepts healthy volunteers
  • 0 views
  • 27 Apr, 2022
  • 1 location