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Found 31 clinical trials
Efficacy Safety and Tolerability of Andrographolides Versus Placebo in Patients With Progressive Forms of MS

patients with the progressive forms of Multiple Sclerosis (MS). The principal outcome is to determine the efficacy, of andrographolide in retarding the progression of brain atrophy in patients

andrographolide
atrophy
brain atrophy
  • 10 views
  • 07 Nov, 2020
  • 1 location
High-dose Vitamin D Supplements in Older Adults

of the treatment effect size on brain atrophy rate. Vitamin D receptor genotype polymorphisms and their impact on response to oral supplementation will also be examined. If vitamin D supplementation

  • 0 views
  • 23 Nov, 2020
  • 1 location
Cognition and MRI Markers in MS Patients With Aubagio Treatment

. . Cognitive dysfunction is correlated with white matter diffuse injury in relapsing-remitting MS (RRMS) patients and brain atrophy However, the relationships between structural brain damage and brain

aubagio
brain atrophy
  • 0 views
  • 26 Jan, 2021
  • 1 location
Mgt of Chronic Subdural Hematoma Using Dexamethasone

Chronic subdural hematoma (cSDH) is a collection of blood and its breakdown products in the subdural compartment. It is a condition frequently seen in any neurosurgical practice. cSDH is believed to arise from tearing of bridging veins as a result of trauma, which may be minor and unapparent to the …

  • 7 views
  • 25 Jan, 2021
  • 1 location
Multiple Sclerosis-Simvastatin Trial 2

years. The investigators found that the rate of brain atrophy (loss of neurons - 'brain shrinkage'), as measured by magnetic resonance imaging (MRI), was reduced in patients receiving simvastatin

  • 174 views
  • 22 Jan, 2021
  • 25 locations
Telmisartan vs. Perindopril in Mild-Moderate Alzheimer's Disease Patients

To conduct a proof of concept study in patients with mild to moderate Alzheimer's Disease in order to determine if there is less global brain atrophy over one year, as measured by ventricular

angiotensin
perindopril
stroke
telmisartan
psychotropic drugs
  • 252 views
  • 24 Jan, 2021
  • 12 locations
Excitatory Prefrontal Weak Current Stimulation in Vegetative Patients

In response to "conscious" EEG findings related to detectable cognitive function that reliably denote awareness in vegetative state patients, in the current study, we will assess the covert conscious EEG activity (as well as standard clinical overt measures) and neuroplasctic propensity (i.e., changes in EEG spectral power synchronization values following …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Novel Assessment of Synaptic Density in Progressive MS

standard 3T MRI measures including global and regional brain atrophy and lesion load with clinical measures of physical disability, cognitive impairment, fatigue and depression in MS patients. Aim

  • 0 views
  • 05 Feb, 2021
  • 1 location
Deferiprone for Ruptured Brain Aneurysm

leads to iron (Fe) and hemoglobin (Hb) accumulation in the brain, which is toxic for neurons. Ferritin (iron reported in the brian) and iron overload leads to brain atrophy, specifically in the mesial

stroke
alzheimer's disease
anesthesia
dementia
cognitive assessment
  • 0 views
  • 18 Apr, 2021
  • 1 location
ALzheimer and MUsic THerapy: Effects of Music Lessons on Brain Plasticity Mood and Quality of Life in Alzheimer Patients

contributions of different factors of the music intervention (cognitive, emotional, and social) to plastic changes of brain morphology, and a potential deceleration of brain atrophy. In addition, quality of

neurodegenerative disorders
alzheimer's disease
  • 4 views
  • 24 Jan, 2021
  • 1 location