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Found 163 clinical trials
Clinical and Experimental Studies to Improve Radiotherapy Outcome in AIDS Cancer Patients

The researchers plan: - To undertake clinical studies of radiotherapy with or without the administration of the chemotherapeutic agent cisplatin, known to be a radiosensitizer; - To perform pre-clinical studies of the radiosensitivity of human fibroblasts and cervical cancer cell lines in culture, with or without the addition of various …

radiosensitizer
cervical carcinoma
cancer
chemotherapeutic agent
  • 197 views
  • 07 Nov, 2020
  • 3 locations
PSMA-PET Registry for Recurrent Prostate Cancer

This study aims to institute a province-wide registry leveraging the availability of a new Positron Emission Tomography tracer, [18F]-DCFPyL and PET expertise across Ontario centers to improve our ability to characterize patterns of recurrence and personalize therapies in men with recurrent prostate cancer after primary treatment.

bone scan
prostatectomy
karnofsky performance status
positron emission tomography
ct scan
  • 50 views
  • 25 Jan, 2021
  • 9 locations
High-Dose-Rate Brachytherapy

This pilot study initiates a research program testing the early technical and clinical performance of a novel procedure for MRI-guided high-dose-rate (HDR) prostate brachytherapy. Testing will

  • 9 views
  • 21 Apr, 2021
  • 1 location
Partial Prostate Salvage High Dose Rate Brachytherapy

% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected

antiandrogen therapy
androgens
ct scan
external beam radiation therapy
bone scan
  • 4 views
  • 07 Jul, 2021
  • 1 location
Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours

The aim of the present trial is to assess the prospective results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy with interstitial hyperthermia (iHT) in a group of selected

  • 0 views
  • 22 Jan, 2021
AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy

This is a phase 1 clinical trial evaluating the safety, tolerability of escalating doses of AGuIX-NP in combination with radiation and cisplatin in patients with locally advanced cervical cancer. Dose escalation will be conducted using the modified toxicity probability interval (mTPI) method. Three dose levels of intravenous AGuIX nanoparticles will …

absolute neutrophil count
aguix-np
coronary artery disease
adenocarcinoma
cancer
  • 11 views
  • 19 Jul, 2021
  • 2 locations
Partial Breast Irradiation With Interstitial High Dose Rate Brachytherapy

demonstrated that most breast cancer recurrences after BCS occur close to the tumour bed. In our phase II prospective study PBI is administered with high-dose-rate brachytherapy in patients with low

breast cancer staging
early-stage breast cancer
partial breast irradiation
  • 0 views
  • 07 Nov, 2020
  • 1 location
Focal Salvage HDR Brachytherapy for Locally Recurrent Prostate Cancer in Patients Treated With Prior Radiotherapy

This purpose of this study is to evaluate the safety and effectiveness of a technique called focal high-dose-rate (HDR) brachytherapy as treatment for prostate cancer that has come back in the

  • 8 views
  • 24 Jan, 2021
  • 2 locations
Optimizing Brachytherapy Application and Delivery With MRI Guidance for Gynecologic Cancer

The aim of this study is to develop new tools using magnetic resonance imaging (MRI) that will improve the brachytherapy procedure and treatment for participants with gynecologic cancer.

cancer
  • 0 views
  • 11 Apr, 2021
  • 1 location
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study

The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s). The

  • 0 views
  • 24 May, 2021
  • 5 locations