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Found 133 clinical trials
PSMA-PET Registry for Recurrent Prostate Cancer (PREP)

This study aims to institute a province-wide registry leveraging the availability of a new Positron Emission Tomography tracer, [18F]-DCFPyL and PET expertise across Ontario centers to improve our ability to characterize patterns of recurrence and personalize therapies in men with recurrent prostate cancer after primary treatment.

ct scan
bone scan
karnofsky performance status
positron emission tomography
  • 15 Feb, 2022
  • 6 locations
High-Dose-Rate Brachytherapy

This pilot study initiates a research program testing the early technical and clinical performance of a novel procedure for MRI-guided high-dose-rate (HDR) prostate brachytherapy. Testing will

  • 24 Jan, 2022
  • 1 location
Partial Prostate Salvage High Dose Rate Brachytherapy (SalvageHDR)

% of patients treated because of inability to deliver sufficient dose through external beam techniques. These patients respond well to re-irradiation using brachytherapy with about 50% of selected

antiandrogen therapy
platelet count
androgen suppression
  • 25 Feb, 2022
  • 1 location
Salvage Brachytherapy and Hyperthermia for Recurrent H&N-tumours (HyBT-H&N)

The aim of the present trial is to assess the prospective results of protocol-based interstitial pulsed-dose-rate (PDR) brachytherapy with interstitial hyperthermia (iHT) in a group of selected

  • 25 Feb, 2022
  • 1 location
AGuIX Gadolinium-based Nanoparticles in Combination With Chemoradiation and Brachytherapy (NANOCOL)

This is a phase 1 clinical trial evaluating the safety, tolerability of escalating doses of AGuIX-NP in combination with radiation and cisplatin in patients with locally advanced cervical cancer. Dose escalation will be conducted using the modified toxicity probability interval (mTPI) method. Three dose levels of intravenous AGuIX nanoparticles will …

external beam radiotherapy
coronary artery disease
absolute neutrophil count
  • 05 Mar, 2022
  • 1 location
Intracavitary Carrier-embedded Cs131 Brachytherapy for Recurrent Brain Metastases: a Randomized Phase II Study

The purpose of this study is to see if Cs-131 brachytherapy is effective in people with recurrent brain cancer who are scheduled to have brain surgery for removal of their tumor(s). The

  • 22 Dec, 2021
  • 5 locations
Using Virtual Reality Technology to Improve Patient Experience and Quality of Care During Brachytherapy

The primary objective is to demonstrate the feasibility of incorporating VR distraction into the brachytherapy and radiotherapy clinical workflow. The secondary objective is to determine

  • 07 Oct, 2022
  • 1 location
Focal Salvage HDR Brachytherapy for Locally Recurrent Prostate Cancer in Patients Treated With Prior Radiotherapy

This purpose of this study is to evaluate the safety and effectiveness of a technique called focal high-dose-rate (HDR) brachytherapy as treatment for prostate cancer that has come back in the

  • 24 Jan, 2021
  • 2 locations
No Surgery Trial / Two Dose-escalation Strategies (Morpheus)

chemotherapy) and an external beam boost of 9 Gy compared to arm B: standard chemoradiation (45 Gy in 25 with concomitant 5-FU or Xeloda chemotherapy) and followed by a brachytherapy boost of 30 Gy in 3

  • 24 Feb, 2022
  • 1 location
An Investigator Initiated Study of Intra-Operative Radiation Therapy (IORT) Using the Xoft Axxent eBx System

assess the rate of ipsilateral breast tumor recurrence in subjects treated with the Xoft Axxent Electronic Brachytherapy System when used for single-fraction, intra-operative radiation therapy treatment

  • 12 Sep, 2021
  • 1 location