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Found 120 clinical trials
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Comparation of Chidamide Plus VRD (Bortezomib Lenalidomide Dexamethasone) With VRD Regimen for Primary High-Risk Multiple Myeloma Patients

In the phase I trial, dose escalation of chidamide will be performed at 4 different dosages (15mg, 20mg, 25mg, 30mg) for optimal dosage, in the phase II trial, the safety and efficacy of chidamide+VRD will be compared with that of VRD regimen.

velcade
plasmacytoma
platelet count
lenalidomide
dexamethasone
  • 2 views
  • 23 Jan, 2021
  • 1 location
None
Daratumumab Combined With Bortezomib Cyclophosphamide and Dexamethasone for the Treatment of Multiple Myeloma Patients Presenting With Extramedullary Disease

This trial will try to establish the feasibility and efficacy of the combination of DaraVCD in Multiple Myeloma (MM) patients presenting with extramedullary disease (EMD). The study will be conducted as a Phase II trial. Forty patients will be included in the study cohort. All patients will be followed closely …

cyclophosphamide
immunoglobulins
plasmacytoma
measurable disease
daratumumab
  • 3 views
  • 10 Feb, 2021
  • 8 locations
None
Study of AO-176 as Monotherapy and in Combination With Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma

and bortezomib in adults with relapsed/refractory multiple myeloma (MM).

cancer
refractory multiple myeloma
measurable disease
dexamethasone
bortezomib
  • 0 views
  • 18 Jul, 2021
  • 7 locations
None
Carfilzomib Lenalidomide and Dexamethasone Versus Bortezomib Lenalidomide and Dexamethasone (KRd vs. VRd) in Patients With Newly Diagnosed Multiple Myeloma (COBRA)

This is a randomized multicenter study that will compare two treatment regimens (Kyprolis, Revlimid, dexamethasone -KRD vs. Velcade, Revlimid, dexamethasone -VRD) for patients with newly diagnosed multiple myeloma.

velcade
chemotherapy regimen
platelet count
immunoglobulins
measurable disease
  • 71 views
  • 14 Jun, 2021
  • 1 location
None
Daratumumab Bortezomib and Dexamethasone Followed by Daratumumab Ixazomib and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma

This phase II trial studies how well daratumumab, bortezomib, and dexamethasone followed by daratumumab, ixazomib, and dexamethasone in treating patients with multiple myeloma that has come back

ixazomib
cancer
progressive disease
measurable disease
bone lesions
  • 3 views
  • 18 Apr, 2021
  • 1 location
None
A Study of Pembrolizumab Added to the Standard First-Line Therapy of Cyclophosphamide Bortezomib and Dexamethasone (CyBorD) for NDMM NTE

This is a phase 2A multi-centre, open label, pilot study of pembrolizumab added to the standard first-line therapy of cyclophosphamide, bortezomib and dexamethasone (CyBorD) in newly diagnosed

dexamethasone
bortezomib
  • 0 views
  • 31 Jul, 2021
  • 4 locations
None
Study of Isatuximab+Lenalidomide+Dexamethasone With/Without Bortezomib in de Novo Non Frail NTE Multiple Myeloma Elderly Patients

induction regimens to lenalidomide-based associations, which is now the backbone of most treatment for NTE patients. Even though the latest melphalan, bortezomib and prednisone (MPV) association was

velcade
prednisone
chemotherapy regimen
cancer
measurable disease
  • 0 views
  • 11 Nov, 2021
  • 1 location
None
Cryocompression Therapy for Peripheral Neuropathy in Patients With Multiple Myeloma

This trial studies how well cryocompression therapy works in reducing bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Peripheral neuropathy (nerve pain or tingling in

paresthesia
chemotherapy regimen
cancer
multiple myeloma
peripheral neuropathy
  • 2 views
  • 18 Nov, 2021
  • 1 location
None
DARA RVD For High Risk SMM

The purpose of this research study is to learn whether the combination of daratumumab SC ( Darzalex Faspro), lenalidomide (Revlimid), bortezomib (Velcade) and dexamethasone works in treating

Accepts healthy volunteers
velcade
cancer
lenalidomide
dexamethasone
  • 0 views
  • 30 Oct, 2021
  • 2 locations
None
Daratumumab-Based Therapy for the Treatment of Newly Diagnosed Multiple Myeloma With Kidney Failure

daratumumab, bortezomib, dexamethasone, and thalidomide or lenalidomide. Daratumumab is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Bortezomib is a drug that

serum calcium
cancer
measurable disease
multiple myeloma
dexamethasone
  • 5 views
  • 20 Jun, 2021
  • 1 location