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Found 120 clinical trials
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Daratumumab Thalidomide and Dexamethasone in Relapse and/or Refractory Myeloma

Myeloma patients who relapse after prior treatment with bortezomib and lenalidomide have survival of less than 1 year. A number of new drugs have been approved for the treatment of relapse

  • 81 views
  • 22 Jan, 2021
  • 3 locations
None
Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

administration of Bortezomib in patients with B-precursor ALL with initial WBC100,000/l will improve treatment outcome? Whether the administration of Idarubicin instead Daunorubicin in low-risk T-ALL

lymphoid leukemia
daunorubicin
adult t-cell leukemia/lymphoma
childhood all
dexamethasone
  • 162 views
  • 23 Jan, 2021
  • 59 locations
None
Treatment Protocol for Children and Adolescents With Acute Lymphoblastic Leukemia - AIEOP-BFM ALL 2017

proportion of all relapses. Targeted therapy is also used in the form of the proteasome inhibitor bortezomib for patients with pB-ALL and slow response to the drugs of the induction chemotherapy with the

vincristine
cytarabine
lymphoid leukemia
cyclophosphamide
minimal residual disease
  • 579 views
  • 18 Jul, 2021
  • 169 locations
None
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

lymphoblastic leukemia (B-ALL) or B-lymphoblastic lymphoma (B-LLy), and the proteasome inhibitor bortezomib for those lacking targetable lesions. To improve overall treatment outcome of T acute

tyrosine
cytarabine
lymphoblastic lymphoma
lymphoid leukemia
bortezomib
  • 231 views
  • 02 Sep, 2021
  • 7 locations
None
International Study for Treatment of High Risk Childhood Relapsed ALL 2010

The main goal of this study is to improve the outcome of children and adolescents with acute lymphoblastic leukemia with high risk first relapse by optimization of treatment strategies within a large international trial and the integration of new agents.

  • 10 views
  • 25 Jan, 2021
  • 19 locations
None
A Study to Evaluate the Efficacy and Safety of Birtamimab in Mayo Stage IV Patients With AL Amyloidosis

A Phase 3 study to evaluate the efficacy and safety of birtamimab plus standard of care compared to placebo plus standard of care in patients with AL amyloidosis in Mayo Stage IV.

  • 4 views
  • 24 Oct, 2021
  • 105 locations
None
A Study to Determine Dose Safety Tolerability and Efficacy of CC-220 Monotherapy and in Combination With Other Treatments in Subjects With Multiple Myeloma

This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the …

bortezomib
anemia
calcium
cancer
high dose chemotherapy
  • 0 views
  • 13 Aug, 2021
  • 79 locations
None
A Study of Daratumumab Monotherapy in Previously Untreated Patients With Stage 3B Light Chain (AL) Amyloidosis

This is an open-label, multicenter, Phase 2 study in subjects with newly diagnosed stage 3B light chain (AL) amyloidosis.

  • 2 views
  • 14 Oct, 2021
  • 5 locations
None
Bortezomib in Intrahepatic Cholangiocellular Carcinoma

This study evaluates the efficacy and safety of second-line treatment of bortezomib in advanced intrahepatic cholangiocarcinoma patients.Half of participants will receive bortezomib while the

oxaliplatin
measurable disease
cholangiocarcinoma
cisplatin/gemcitabine
solid tumors
  • 2 views
  • 21 Jan, 2021
  • 1 location
None
Isatuximab Lenalidomide Bortezomib and Dexamethasone in NDMM

This research is testing whether the investigational drug isatuximab is safe and effective when used in combination with standard agents for the treatment of newly diagnosed multiple myeloma.

platelet count
neutrophil count
bortezomib
measurable disease
lenalidomide
  • 0 views
  • 01 Aug, 2021
  • 1 location