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Found 279 clinical trials
Trial of Parkinson's And Zoledronic Acid (TOPAZ)

This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60 years and older with Parkinson's disease and parkinsonism with at least 2 years of follow-up. A total of 3500 participants will …

supranuclear palsy
parkinson's disease
zoledronic acid
cognitive assessment
  • 12 May, 2022
  • 53 locations
ExclUsive endocRine Therapy Or Partial Breast Irradiation for Women Aged 70 Years Early Stage Breast Cancer

Rationale and relevance for patients and the scientific community. In low risk early stage patients 70 years, exclusive Partial Breast Irradiation (PBI) as radiation therapy (RT) approach might be superior in terms of Health-Related Quality of Life (HRQoL), when compared to exclusive endocrine therapy (ET) following breast-conserving surgery (BCS). Assuming …

  • 16 Apr, 2021
  • 1 location
Reference Curve on Bone Mineral Density in Men (COURDO2)

In men, the hope of lower life, the absence of equivalent of menopause and the existence of a higher peak bone mass are the three factors that explain the lower incidence of osteoporosis in men

bone densitometry
Accepts healthy volunteers
  • 25 Feb, 2022
  • 3 locations
The Optimal Long Term Treatment Strategy of Anti-resorptive Medications---The Extension of Denosumab Sequential Therapy

This study is to investigate whether the alternating use of Prolia (Denosumab) and Aclasta (Zoledronic acid) can continue to increase bone density.

zoledronic acid
  • 01 Nov, 2021
  • 1 location
Reinforced PTFE Meshes Versus Customized Titanium Meshes

The objective of this study is to compare two surgical techniques for the treatment of the maxillary and mandibular bone atrophies.. Therefore, the main purpose is to compare the (i) the percentage of post-operative complications (ii) the three-dimensional bone gain with customized titanium meshes (test group - the medical device …

partial edentulism
  • 02 Mar, 2022
  • 1 location
Surgical Approach in Hemiarthroplasty. A Randomized Clinical Trial Comparing Posterior and Anterior Approach

Dislocated femoral neck fractures are routinely treated with cemented hemiartroplasty and the direct lateral approach (Hardinge) has commonly been used in Norway. The investigators have lately witnessed a significant change in the prefered surgical approaches in total hip arthroplasty (THA) in favor of the posterior and anterior approaches. The direct …

  • 22 Mar, 2022
  • 1 location
BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study (BONE:STAR)

The primarily objective of this study is to assess the effect of switching from Tenofovir Disoproxil Fumurate (TDF) to TAF based ART on bone mass and turnover among women on DMPA for

bone mineral density
antiretroviral therapy
  • 24 Feb, 2022
  • 1 location
Freeze-dried Bovine Hydroxyapatite/Secretome Composite for Bone Defects

This clinical trial aims to investigate the efficacy of freeze-dried bovine hydroxyapatite/secretome composite application for the management of long bone defects and other bone healing disorders in the lower extremities.

  • 07 Aug, 2021
  • 1 location
Marginal Bone Loss in Single Implant Restaurations With Different Methods

The investigator is going to measure the marginal bone loss in single implant restaurations with three different methods: direct overcast, milled cad/cam direct to implant restauration and milled cad/cam implant restauration using an transepithelial pilar

Accepts healthy volunteers
  • 27 Apr, 2022
Evaluation of Implant Stability in Low Quality Bone Following The Use of Osseodensifiers Versus Ridge Expanders

the use of osseodensification technique compared to ridge expansion screws in low bone quality

Accepts healthy volunteers
  • 01 May, 2022
  • 1 location