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Found 247 clinical trials
SUPR-3D: Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With Bone Metastases

The primary objective is to patient-reported Quality of Life related to complete control of Radiation Induced Nausea and Vomiting (RINV) between standard palliative radiotherapy and VMAT. Secondarily, we will assess rate of complete control of RINV. However, the investigators hypothesize that there will be no difference in pain response between …

nausea
primary cancer
bone metastases
vomiting
antiemetic
  • 132 views
  • 22 Apr, 2022
  • 5 locations
Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

(platinum + paclitaxel) in the treatment of patients with bone metastases cancer with unknown primary, and provide a better treatment plan for these patients. Primary outcome: Objective

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Preliminary Evaluation of Uptake in Bone Metastases and Biodistribution of [68Ga]P15-041

A phase1 study to demonstrate [68Ga]P15-041 binding to bone metastases in prostate cancer and determination of human dosimetry.

bone metastases
metastasis
cancer
  • 0 views
  • 11 May, 2022
  • 1 location
Palliative UNConventional Hypofractionation Trial for Metastatic Bone Disease

This is a randomized Phase III study evaluating the efficacy of hypofractionated and dose-escalated palliative radiation therapy in metastatic bone disease (MBD). Patients will be randomized 1:1 to the conventional (8 Gy in a single fraction) and experimental (16 Gy in 2 fractions) groups with baseline and subsequent assessment of …

  • 0 views
  • 03 Dec, 2021
  • 1 location
Denosumab and Nivolumab Combination as 2d-line Therapy in Stage IV NSC Lung Cancer With Bone Metastases (DENIVOS)

Bone metastases are common in Non-Small Cell Lung Cancer (NSCLC). They most often occur during disease progression. It is thought that more than half of the patients with bone metastases will

stage iv non-small cell lung cancer
lung carcinoma
liver metastasis
neutrophil count
squamous cell carcinoma
  • 102 views
  • 18 Nov, 2021
  • 44 locations
Prostate Cancer With OligometaSTatic Relapse: Combining Stereotactic Ablative Radiotherapy and Durvalumab (MEDI4736) (POSTCARD)

As in other solid tumours, increasing evidence indicates that patients diagnosed with a limited number of prostate cancer metastases, so-called oligometastases, have a better prognosis compared with patients with extensive metastatic disease. Survival of patients with three or fewer metastases was superior compared with patients with more than three lesions. …

platelet count
stereotactic body radiation therapy
durvalumab
neutrophil count
cancer
  • 16 views
  • 08 Feb, 2022
  • 1 location
A Trial to Improve Quality of Life With Stereotactic Body Radiotherapy for Patients With Painful Bone Metastases (ROBOMET)

This is a phase III randomized-controlled, single-blind study comparing the standard schedule for antalgic radiotherapy of a single fraction of 8.0 Gy delivered through three-dimensional conformal radiotherapy (3D-CRT) to a single fraction of 20.0 Gy delivered through stereotactic body radiotherapy (SBRT). The primary aim of this trial is to double …

stereotactic body radiation therapy
stereotactic body radiotherapy
cancer
bone metastases
metastasis
  • 3 views
  • 13 Feb, 2022
  • 1 location
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

cancer that has spread to the bones (bone metastases). Bone is a common site of metastasis in advanced cancer, and bone metastases often result in debilitating cancer-related pain. The current standard

  • 0 views
  • 24 Mar, 2022
  • 1 location
Single Arm Phase II Study of Fractionated Stereotatic Radiation Therapy (FSRT) for Bone Metastases in Breast Cancer

Fractionated stereotatic radiation therapy (FSRT) that very precisely delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. The purpose of this study is to find out if FSRT is safe and effective in the treatment of metastatic …

invasive breast cancer
tumor cells
metastasis
bisphosphonate
  • 0 views
  • 11 Jul, 2021
  • 1 location
Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

This phase I/II trial studies the best dose and side effects of olaparib and how well it works with radium Ra 223 dichloride in treating patients with castration-resistant prostate cancer that has spread to the bone and other places in the body (metastatic). PARPs are proteins that help repair DNA …

gilbert's syndrome
apalutamide
neutrophil count
bone disease
serum testosterone
  • 92 views
  • 14 Jun, 2022
  • 12 locations