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Found 54 clinical trials
Unrelated And Partially Matched Related Donor PSCT w/ T Cell Receptor (TCR) αβ Depletion for Patients With BMF

for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes.

severe aplastic anemia
stem cell transplantation
flow cytometry
colony stimulating factor
bone marrow failure
  • 17 views
  • 12 Mar, 2022
  • 1 location
TPO-Mimetic Use in Children for Hematopoietic Failure

scope of bone marrow failure disorders including acquired and inherited conditions as a first line of therapy along with standard of care.

romiplostim
severe aplastic anemia
stem cell transplantation
leukemia
cell transplantation
  • 0 views
  • 07 Oct, 2022
  • 1 location
Hematopoietic Stem Cell Transplant for Dyskeratosis Congenita or Severe Aplastic Anemia

congenita or severe aplastic anemia who have bone marrow failure characterized by a requirement for red blood cell and platelet transfusions. Three different preparative regimens are included based on

antithymocyte globulin
severe aplastic anemia
cytopenia
aplastic anemia
telomerase rna
  • 24 views
  • 24 Mar, 2022
  • 1 location
Expanded Access Protocol Using CD3+/CD19+ Depleted PBSC

The goal of this protocol is to expand access for patients who lack a fully HLA (Human leukocyte antigen) matched sibling donor and who are candidates for allogeneic hematopoietic stem cell transplant (HSCT). These patients have a serious or immediately life-threatening disease for which HSCT is indicated. These patients are …

immunodeficiency
stem cell transplantation
chronic leukemias
acute leukemia
graft versus host disease
  • 130 views
  • 17 Nov, 2021
  • 1 location
Reduced Intensity Conditioning and Familial HLA-Mismatched BMT for Non-Malignant Disorders

This study is designed to estimate the efficacy and toxicity of familial HLA mismatched bone marrow transplants in patients with non-malignant disease who are less than 21 years of age and could benefit from the procedure.

transfusion of red blood cells
malignant disease
chest syndrome
melphalan
hemoglobin s
  • 18 views
  • 07 Mar, 2022
  • 2 locations
Gene Therapy for Fanconi Anemia, Complementation Group A

be infused intravenously back to the patient with the goal of preventing bone marrow failure.

  • 1 views
  • 25 Feb, 2022
  • 1 location
5-Azacitidine and Decitabine Epigenetic Therapy for Myeloid Malignancies

Another term for myelodysplastic syndrome is bone marrow failure. The bone marrow is where components of blood such as red cells, platelets and white cells are made. In bone marrow failure, the

azacitidine
colony stimulating factor
cytopenia
decitabine
direct bilirubin
  • 0 views
  • 04 Oct, 2022
  • 1 location
Lentiviral-mediated Gene Therapy for Pediatric Patients With Fanconi Anemia Subtype A

stem cells will be infused intravenously back to the patient with the goal of preventing bone marrow failure.

  • 2 views
  • 16 Feb, 2022
Quercetin Chemoprevention for Squamous Cell Carcinoma in Patients With Fanconi Anemia

Fanconi anemia (FA) is an autosomal recessive disease characterized by progressive bone marrow failure, variable congenital abnormalities and a predisposition to malignancy, particularly acute

fanconi syndrome
cancer
leukemia
anemia
graft versus host disease
  • 24 views
  • 25 Mar, 2022
  • 1 location
Impact of 2 Transfusion Strategies on Quality of Life of Multitransfused Patients With Low-risk Myelodysplastic Syndrome (SMD-transfu)

transformation. Anemia is the most common manifestation of bone marrow failure in MDS. After failure with first-line treatment by Erythropoietin, patients survive in average 5 years under long term blood

antithymocyte globulin
decitabine
blood transfusion
lenalidomide
anemia
  • 0 views
  • 18 Apr, 2022
  • 17 locations