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Found 25 clinical trials
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Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

Background: Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

anemia
aplastic anemia
myelodysplastic syndromes
myelodysplastic syndrome (mds)
anemia studies
  • 86 views
  • 22 Dec, 2020
  • 1 location
Improving White Blood Cell Collection From Healthy Donors

Background White blood cells called granulocytes help the body fight infection. People who have had chemotherapy or bone marrow transplants may have very low numbers of these cells. Transfusions of these cells can help improve the body's ability to fight infection. However, most of the cells are located in the …

  • 35 views
  • 26 Jan, 2021
  • 1 location
Fludarabine Based RIC for Bone Marrow Failure Syndromes

This is a pilot study to determine whether fludarabine-based reduced intensity conditioning (RIC) regimens facilitate successful donor engraftment of patients with acquired aplastic anemia (AA) and Inherited bone marrow failure (iBMF) syndromes undergoing Matched related donor bone marrow transplant (MRD-BMT).

  • 0 views
  • 23 Jul, 2021
  • 1 location
Reduced Intensity BMT for Immune Dysregulatory and Bone Marrow Failure Syndromes Using Post-Transplant Cyclophosphamide

cyclophosphamide (PTCy) for patients with primary immune deficiencies (PID), immune dysregulatory syndromes (IDS), and inherited bone marrow failure syndromes (IBMFS).

cyclophosphamide
thrombocytopenia absent radii
lad-1
ipex
alemtuzumab
  • 0 views
  • 24 Jan, 2021
  • 1 location
Pre-myeloid Cancer and Bone Marrow Failure Clinic Study

The use of genomics and functional translational studies is to identify and diagnose patients with precursor features of myeloid neoplasms and inherited bone marrow failure syndromes.

  • 0 views
  • 19 Mar, 2021
  • 1 location
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells

Background Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

white blood cells
cyclophosphamide
antithymocyte globulin
cyclosporine
fludarabine
  • 52 views
  • 23 Jul, 2021
  • 2 locations
Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT BMT or PBSCT

The objective of this study is to evaluate the efficacy of using a reduced-intensity condition (RIC) regimen with umbilical cord blood transplant (UCBT), double cord UCBT, matched unrelated donor (MUD) bone marrow transplant (BMT) or peripheral blood stem cell transplant (PBSCT) in patients with non-malignant disorders that are amenable to …

  • 22 views
  • 15 May, 2021
  • 2 locations
Unrelated And Partially Matched Related Donor PSCT w/ TCR Depletion for Patients With BMF

This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes.

shwachman-diamond syndrome
neutropenia
paroxysmal nocturnal hemoglobinuria
stem cell transplantation
antibiotics
  • 17 views
  • 25 Jan, 2021
  • 1 location
TCR Alpha Beta T-cell Depleted Haploidentical HCT in the Treatment of Non-Malignant Hematological Disorders in Children

This research is being done to learn if a new type of haploidentical transplantation using TCR alpha beta and CD19 depleted stem cell graft from the donor is safe and effective to treat the patient's underlying condition. This study will use stem cells obtained via peripheral blood or bone marrow …

acute chest syndrome
gilbert's syndrome
thalassemia
hydroxyurea
immune thrombocytopenia
  • 0 views
  • 24 Jan, 2021
  • 1 location
Haploidentical HCT for Severe Aplastic Anemia

This study is a prospective, single center phase II clinical trial in which patients with Severe Aplastic Anemia (SAA) or Telomere Biology Disorders (TBD) will receive a haploidentical transplantation. The purpose of this study is to learn more about newer methods of transplanting blood forming cells donated by a family …

glomerular filtration rate
red blood cell transfusion
cyclophosphamide
fludarabine
ejection fraction
  • 5 views
  • 04 Apr, 2021
  • 1 location