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Found 57 clinical trials
featured
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused with a Reduced Dose of Non-Mobilized Donor T-Cells

Background: Stem cell transplants from related donors (allogenic stem cell transplants) can be used to treat individuals with certain kinds of severe blood diseases or cancers, such as severe anemia. Allogenic stem cell transplants encourage the growth of new bone marrow to replace that of the recipient. Because stem cell …

myelodysplastic syndromes
aplastic anemia
anemia
myelodysplastic syndrome (mds)
anemia studies
  • 86 views
  • 22 Dec, 2020
  • 1 location
featured
A Randomized Trial of Sirolimus (Rapamune) for Relapse Prevention in Patients with Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background: People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

myelodysplastic syndromes
aplastic anemia
anemia
myelodysplastic syndrome (mds)
anemia studies
  • 61 views
  • 22 Dec, 2020
  • 1 location
featured
Low-Dose Danazol for the Treatment of Telomere Related Diseases

DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to see …

pulmonary fibrosis
lung disease
hepatic fibrosis
liver disease
anemia
  • 293 views
  • 22 Dec, 2020
  • 1 location
featured
Eltrombopag Added to Standard Immunosuppression in Treatment-Naive Severe Aplastic Anemia

Background: Severe aplastic anemia is a rare and serious blood disorder. It happens when the immune system starts to attack the bone marrow cells. This causes the bone marrow to stop making red blood cells, platelets, and white blood cells. Standard treatment for this disease is horse-ATG and cyclosporine, which …

myelodysplastic syndromes
aplastic anemia
anemia
myelodysplastic syndrome (mds)
anemia studies
  • 123 views
  • 22 Dec, 2020
  • 1 location
Haploidentical Bone Marrow Transplant With Post-Transplant Cyclophosphamide for Patients With Severe Aplastic Anemia

Severe aplastic anemia is a rare and serious form of bone marrow failure related to an immune-mediated mechanism that results in severe pancytopenia and high risk for infections and bleeding

anemia severe
fludarabine
hla-a
cyclophosphamide
pancytopenia
  • 20 views
  • 05 Mar, 2021
  • 2 locations
Lentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency

function of the bone marrow. HSCT is the first choice of treatment for patients with signs of bone marrow failure and a fully-matched related donor. However, patients without a fully-matched related donor

  • 3 views
  • 18 Feb, 2021
  • 1 location
Optimizing Haploidentical Aplastic Anemia Transplantation (BMT CTN 1502)

This study is a prospective, multicenter phase II study with patients receiving haploidentical transplantation for Severe Aplastic Anemia (SAA). The primary objective is to assess overall survival (OS) at 1 year post-hematopoietic stem cell transplantation (HSCT).

mycophenolate
immunosuppressant
hla-a
cyclophosphamide
fludarabine
  • 51 views
  • 24 Jan, 2021
  • 28 locations
Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive Therapy

Background People with severe aplastic anemia (SAA) do not make enough red and white blood cells, and/or platelets. Their body's immune system stops the bone marrow from making these cells. The treatment cyclosporine leads to better blood counts. But when this treatment is stopped, the disease may return in 1 …

immunosuppressant
cyclosporine
white blood cells
cyclophosphamide
neutrophil count
  • 7 views
  • 02 Apr, 2021
  • 1 location
Treatment of Refractory Diamond-Blackfan Anemia With Eltrombopag

Background Diamond-Blackfan anemia (DBA) is treated with steroids. But some people cannot take steroids, or steroids don t work. Other patients must get blood transfusions regularly which are time consuming and can have significant side effects. The drug eltrombopag can increase red blood cells. Researchers want to see if it …

cell counts
  • 1 views
  • 27 Jan, 2021
  • 1 location
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Background Severe aplastic anemia (SAA) is a rare and serious blood disorder. It causes the immune system to turn against bone marrow cells. Standard treatment for SSA is a combination of 3 drugs (Cyclosporine [CsA], Eltrombopag [EPAG], and horse anti-thymocyte globulin [h-ATG]). Researchers want to see if starting people at …

immunosuppressant
cyclosporine
horse anti-thymocyte globulin
antithymocyte globulin
blood disorder
  • 1 views
  • 27 Feb, 2021
  • 1 location